2024
DOI: 10.20944/preprints202401.1198.v1
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Clinico-radiological outcomes in WNT-subgroup medulloblastoma

Shakthivel Mani,
Abhishek Chatterjee,
Archya Dasgupta
et al.

Abstract: Background: Medulloblastoma (MB) comprises four broad molecular subgroups - wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4 respectively with subgroup-specific developmental origins, unique genetic profiles, distinct clinico-demographic characteristics, and diverse clinical outcomes. WNT-MB has the best outcomes (5-year survival >90%) with contemporary multi-modality treatment prompting attempts at treatment de-intensification to reduce late toxicity. This is a retrospective audit of clinical… Show more

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