Clinicobacteriological study of chronic dacryocystitis in Egypt

Abstract

Background: Empirical antibiotic treatment is a common practice to manage chronic dacryocystitis in many healthcare settings in spite of the probability for changing in the types of microbial isolates. The aims of this study were to find out the current clinicomicrobiological profile of adult cases with chronic dacryocystitis and to determine the antibiogram of the isolated organisms to the commonly prescribed antibiotics. Results: Of the 25 samples obtained, 15 (60%) yielded a positive culture, 12 (48%) showed single bacterial isolate while 3 (12%) had mixed (two types) bacterial isolates. A total of 18 different strains of microorganisms were obtained from 25 cases, with 12/18 (66.7%) Gram-positive, 5/18 (27.7%) Gram-negative isolates, and 1/18 (5.5%) was fungal isolate. Coagulase-negative staphylococci were the most frequently found Gram-positive bacteria (22.2%), while Klebsiella species was the predominant of Gram-negative bacteria (16.6%). The majority of the isolated bacterial strains were sensitive to gatifloxacin (88%) and amikacin (88%) while the main resistance of the bacterial isolates, recovered from chronic dacryocystitis, was to cephalexin (59%). Conclusion: There is a continuous possibility of changing the type of pathogens responsible for dacryocystitis as well as their susceptibility to antibiotics. Microbiological study with microbial culture and antibiotic sensitivity test has to be done to all cases of chronic dacryocystitis for a better choice of antibiotic prophylaxis and treatment options, and to guard against the emergence of more drug-resistant strains.

The Bacterial Profile and Microbial Susceptibility of Acute and Chronic Dacryocystitis in Matini Hospital, Kashan, Iran

“…Among all the analyzed P. aeruginosa isolates, the highest resistance was observed to aztreonam. The results of Negm et al's study confirm our results, showing that Gram-negative isolates were more sensitive to the third generation of cephalosporins, such as cefotaxime (80%) and ceftazidime (60%) (2). In the Enterobacteriaceae group, the highest (100%) sensitivity was to amikacin, gentamicin, ciprofloxacin, cefotaxime, piperacillin-tazobactam, and augmentin in Klebsiella.…”

“…In this situation, microorganisms, such as normal flora or pathogens, can be colonized within the lacrimal sac (1). Clinical symptoms of dacryocystitis include pain, redness, and swelling over the inner side of the lower eyelid (2). The microbial agents of this disease have not been described in different geographical areas.…”

Chronic Dacryocystitis: Clinico-Bacteriological Profile and its Antibiogram at a Tertiary care Hospital in Belagavi, Karnataka

“…Clinical specimens for bacterial examination were collected from all these 60 (from a total of 67 eyes, as 7 patients had bilateral involvement) clinically diagnosed cases of chronic dacryocystitis after obtaining informed consent. Chronic dacryocystitis patients are the ones with persistent watering of the eyes for longer duration, thickening of the lacrimal drainage system and regurgitation of mucoid and mucopurulent material on pressure over lacrimal sac area or on irrigation of lacrimal drainage system 12 . The patients were asked to wash the face with soap and water, especially around the affected eye, and allowed to air dry.…”

Bacterial profiles and antibiotic susceptibility pattern in patients with chronic dacryocystitis

“…Insufficient lacrimal drainage leads to the colonization of microorganisms, leading to infection in the lacrimal sac. In previous studies, it has been shown that inflammation and fibrosis occur secondary to bacterial colonization in the lumen of the lacrimal sac in chronic cases [1,5]. Chronic dacryocystitis poses a potential risk of infection to the cornea and other neighboring tissues [6].…”