Clinicoepidemiologic considerations in the diagnosis of tuberculous lymphadenitis: evidence from a high burden country

Assefa, Wubshet; Wonde, Tewodros Eshete; Solomon, Yoseph; Mekasha, Bersabeh

doi:10.1016/j.ijid.2022.09.030

Cited by 6 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 In studies conducted in Guangxi Zhuang Self-Governing Region, Ethiopia, Tunisia and India, cervical lymph node involvement was observed most frequently, similar to our study. 15,19,20,21 In our study, bone-joint involvement (18.7%) and peritoneal involvement (10.4%) were the most common after lymph node involvement among EPTB cases.In the study of Binici İ. et al it was found that peritoneal (13.4%), pleural (9.9%) and spondylitis (9.2%) involvement followed lymph node involvement, respectively (9).In a study conducted by Raval A et al in India, it was observed that vertebral (20.6%), abdominal (7.84%) and central nervous system (7.35%) involvement followed by lymph node (41.67%) involvement. 21 Among the methods used in the diagnosis of EPTB cases in our study, histopathological methods (56.5%) were used most frequently, followed by other methods (radiological examinations, TST, liquid adenosine deaminase, lymphocyte-rich fluid, etc.)…”

Section: Discussionmentioning

confidence: 52%

Enfeksiyon hastalıkları polikliniğinde ekstrapulmoner tüberküloz hastalarının epidemiyolojik ve klinik tutulumlarının yıllara göre dağılımı

ASLAN,

SAYİNER

2023

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

Aim: It was aimed to examine the patients diagnosed with extrapulmonary tuberculosis (EPTB) in terms of diagnostic methods and demographic characteristics. Materials and Methods: The files of patients with EPTB who were followed up in the infectious disease’s outpatient clinic between 2012 and 2022 in our study were retrospectively reviewed. Results: Of the patients diagnosed with EPTB, 70.8% (102) were female and 29.2% (42) were male. The ages of the patients ranged from 20 to 88, the mean age of women was 54.2, and the mean age of men was 55. The most common site of involvement in these patients was lymph node involvement. This was followed by bone-joint, peritoneal, central nervous system and genitourinary system involvement, respectively. Histopathological methods were used most frequently in 81 (56.5%) of the patients. Conclusion: The signs and symptoms of EPTB differ according to the organs and tissues involved in the body. We believe that EPTB should be considered in the differential diagnosis in endemic regions.

show abstract

Section: Discussionmentioning

confidence: 52%

Enfeksiyon hastalıkları polikliniğinde ekstrapulmoner tüberküloz hastalarının epidemiyolojik ve klinik tutulumlarının yıllara göre dağılımı

ASLAN,

SAYİNER

2023

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

show abstract

“…TB lymphadenitis is more frequent in children and females, with the peak age of onset ranging 15–30 years in high TB burden countries [ 11 ]. In the present study, the age of patients with TBIL ranged 26.5–54.5 years and only 36.36% (12/33) were aged > 40 years, these patients were markedly younger than those with SAIL (80%, 40/50, p < 0.01).…”

Section: Discussionmentioning

confidence: 99%

Xpert MTB/RIF assay for the differential diagnosis between sarcoidosis and tuberculosis intrathoracic lymphadenopathy

He,

Zhang,

Zhou

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

Background The aim of this study was to evaluate the role of Xpert MTB/RIF assay in the detection of Mycobacterium tuberculosis for differentiating tuberculosis intrathoracic lymphadenopathy from sarcoidosis intrathoracic lymphadenopathy. Methods The patients who were suspected to having sarcoidosis or tuberculosis intrathoracic lymphadenopathy at the Shanghai Pulmonary Hospital between October 1, 2020 and June 30, 2021 were retrospectively evaluated in this study. All patients underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and Xpert analysis. Differences in clinical and radiological features were recorded. The diagnostic performances of EBUS-TBNA Xpert, acid-fast bacilli, culture, and peripheral blood QuantiFERON-TB Gold (QFT) for differentiating sarcoidosis from tuberculosis intrathoracic lymphadenopathy were analyzed. Results A total of 119 patients were included in this analysis. Of those, 83 patients were finally diagnosed with sarcoidosis (N = 50) and tuberculosis (N = 33) intrathoracic lymphadenopathy. Young individuals were more likely to have tuberculosis versus sarcoidosis intrathoracic lymphadenopathy (P = 0.006). Markers of inflammation, including fever, leukocytes, and serum ferritin levels, were significantly higher in tuberculosis versus sarcoidosis intrathoracic lymphadenopathy (P < 0.01). Bilateral lung involvement and symmetry intrathoracic lymphadenopathy were more common in sarcoidosis intrathoracic lymphadenopathy (P < 0.01). In addition, the longest diameter of intrathoracic lymphadenopathy (in cm) was significantly larger in sarcoidosis intrathoracic lymphadenopathy (P = 0.001). However, the largest diameter of lung lesions was significantly shorter (P = 0.005). The sensitivity and specificity values of Xpert and QFT for differentiating these two diseases were 69.70% and 100%, and 96.43% and 91.84%, respectively. Conclusion Xpert MTB/RIF is recommended for the diagnosis of tuberculosis intrathoracic lymphadenopathy using EBUS-TBNA samples. A negative QFT suggests the exclusion of the diagnosis of tuberculosis intrathoracic lymphadenopathy.

show abstract

“…15 Limfadenitis granulomatosa merupakan manifestasi terbanyak dari tuberkulosis ekstrapulmonal. 8,13,[16][17][18][19][20] Bandung pada periode Januari-Desember 2022 berdasarkan jenis kelamin, usia, dan indeks massa tubuh (IMT).…”

Section: Pendahuluanunclassified

Gambaran Klinis dan Histopatologis Pasien Limfadenopati Granulomatosa yang Berobat di Rumah Sakit Muhammadiyah Bandung

Widiyastuti,

Ismawati,

Rachmawati

2024

J Integr Kes Sains

View full text Add to dashboard Cite

Limfadenopati granulomatosa memiliki beragam etiologi yang mendasarinya. Secara garis besar dapat diklasifikasikan karena infeksi dan non infeksi. Gambaran histopatologi limfadenitis granulomatosa membentuk struktur khusus seperti sel epiteloid disertai dengan sebukan sel radang, namun tidak spesifik. Limfadenitis tuberkulosis merupakan penyebab tersering limfadenopati di daerah endemis tuberkulosis seperti di Indonesia. Karakteristik klinis dan penunjang seperti pemeriksaan rontgen dapat membantu mendiagnosis penyakit yang mendasari lesi ini. Tujuan penelitian ini mengetahui gambaran klinis dan histopatologis limfadenitis granulomatosa di Rumah Sakit Muhammadiyah Bandung yang diharapkan dapat membantu mengarahkan diagnosis. Penelitian ini merupakan studi deskriptif kuantitatif yang diambil dari data rekam medis 40 pasien limfadenopati granulomatosa di Rumah Sakit Muhammadiyah Bandung periode Januari–Desember 2022. Hasil penelitian menunjukkan sebanyak 52% adalah perempuan, terbanyak di rentang usia 22–31 tahun (30%). Lesi terbanyak ditemukan di daerah leher kanan (35%) dengan gejala penyerta terbanyak adalah nyeri (20%). Hasil rontgen normal (23%) ditemukan lebih banyak dibanding dengan yang disertai kelainan. Karakteristik gambaran distribusi histopatologis paling banyak adalah sel radang limfosit (100%), histiosit (95%), dan sel epiteloid (92%), sedangkan paling sedikit adalah datia benda asing (20%). Limfadenitis tuberkulosis merupakan penyakit tersering yang mengakibatkan benjolan di leher dan menimbulkan gambaran histopatologi berupa granuloma yang beragam mulai dari granuloma bernekrosis, granuloma non nekrosis, dan granuloma supuratif. Pada penelitian ini didapatkan ketiga gambaran granuloma tersebut. Meskipun tempat penelitian ini di Indonesia merupakan endemi tuberkulosis, namun tetap perlu dipikirkan diagnosis banding lain yang harus disingkirkan sebelum menegakkan diagnosis yang tepat.AbstractGranulomatous limphadenopaty has various underlying etiologies. In general granulomatous lymphadenopathy can be classified as infectious and non-infectious. The histopathologic features of granulomatous lymphadenopathy creates a special structure with epitheloid cells surrounded by inflammatory cells, however these are not spesific. Tuberculous lymphadenitis is the frequent cause for lymphadenopathy in endemic area for tuberculosis as Indonesia. The clinical features and chest X-ray examination can be helpful for establishing the underlying diagnosis for the lesion. The aim of this research is to determine the clinical and histopathological features of granulomatous limphadenopaty at the Muhammadiyah Bandung Hospital for the period January–December 2022 which is expected to help in directing the diagnosis later. This study is a quantitative descriptional study from medical records of 40 patients with granulomatous lymphadenopathy admitted to Muhammadiyah Hospital in periode of January–December 2022. The results showed 52% patients were female, mostly in age group of 22–31 years old (30%). Most lesions located at right neck (35%), with pain as most frequent accompanied symptom (20%). Normal chest X-rays were more frequent than those with abnormal findings. The histopathologic features of the lesion showed the most histopathological distribution is lymphocyte inflammatory cells (100%), histiocytes (95%), and epithelioid cells (92%), while the least is foreign body datia (20%). Tuberculous lymphadenitis is the commonest etiology for diseases presenting with cervical adenopathy with histopatologic features of granuloma ranging from necrotizing, non necrotizing and suppurative granuloma. The three types of granulomas were found in this study. Despite that Indonesia the endemic area for tuberculosis, other differential diagnosis still needed to be eliminated before appropriate diagnosis can be made.

show abstract

Clinicoepidemiologic considerations in the diagnosis of tuberculous lymphadenitis: evidence from a high burden country

Cited by 6 publications

References 23 publications

Enfeksiyon hastalıkları polikliniğinde ekstrapulmoner tüberküloz hastalarının epidemiyolojik ve klinik tutulumlarının yıllara göre dağılımı

Enfeksiyon hastalıkları polikliniğinde ekstrapulmoner tüberküloz hastalarının epidemiyolojik ve klinik tutulumlarının yıllara göre dağılımı

Xpert MTB/RIF assay for the differential diagnosis between sarcoidosis and tuberculosis intrathoracic lymphadenopathy

Gambaran Klinis dan Histopatologis Pasien Limfadenopati Granulomatosa yang Berobat di Rumah Sakit Muhammadiyah Bandung

Contact Info

Product

Resources

About