Clinicoetiological Profile of Neonatal Seizures in a Tertiary Care Hospital

Rastogi, Shantanu; Lata, Preeti; Prasad, Psv

doi:10.32677/ijch.2017.v04.i04.029

Cited by 4 publications

(10 citation statements)

References 8 publications

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“…This is due to the fact that some infections have ability to damage and passé blood brain barrier that increases the translocation of cytokines, carrying the proinflammatory response from the serum into the brain and favoring seizure susceptibility (30,31) Lastly, the odds of occurrence of neonatal seizure among neonates with perinatal asphyxia were 8.25 times higher than its counterpart. Which was consistent with studies in Italy(32), in Ethiopia at university of Gonder (32),India (28).This due to when hypoxia and ischemia occurs, there is a cascade of events that cause a decrease in energy production in the brain. In turn that leads to an increase in an excitatory neurotransmitter called glutamate, which causes excessive activity in the cortex(33).…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, neonates with blood glucose level < 40gm/dl were five times more likely to develop neonatal seizure than neonates whose blood glucose level was between 40gm/dl and 125gm/dl. This finding is also in line with studies conducted in Iran (27), India (28).In fact, babies need sugar or glucose for energy and most of the glucose in their body is being used up by their brains. As a result, the brain depends on continuous blood glucose supply as its main source of energy.…”

Section: Discussionsupporting

confidence: 90%

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Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Alene,

Tsega,

terefe

et al. 2024

Preprint

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Background: Neonatal seizure is a common medical emergency that signals severe insult to the neonatal brain. It is a major risk factor for neonatal morbidity and mortality. It has a wide worldwide variation, ranging from 5 per 1,000 live births in the United States of America to 39.5 per 1,000 live births in Kenya. To decrease this significant figure, it is better to investigate its causes further. Therefore, this study aimed to assess its determinants since there was no prior evidence about it in the context of study area. Objective: Aim to assess the determinants of neonatal seizures among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023. Methods: An institution based unmatched case-control study was conducted on 531 admitted eligible neonates from January 1, 2023, to May 30, 2023. A pretested tool was employed to collect data. The collected data were coded, edited, and entered into Epi-data version 3.1 and then exported to SPSS 26. Chi-square and odds ratios were used to assess the relationship between factors associated with the occurrence of neonatal seizure. Model goodness of fit was tested by Hosmer and Lemeshow. Bivariate and multivariate analysis was declared at P<0.25 and P<0.05 respectively to show a significant association with neonatal seizure at a 95% level of significance. Results: A total of 506 (130 cases and 376 controls) of admitted neonates were used in the final analysis model. Neonates admitted within 24 hours of birth [AOR; 5.98 (95%, CI: 2.18-16.43)], gestational age <32 weeks [AOR; 2.89 (95%, CI: 1.29-6.53)], body temperature >37.5℃ [AOR; 4.82 (95%, CI: 1.82-12.76)], blood glucose level < 40g/dl [AOR; 4.95 (95%, CI: 2.06,11.88)], neonatal sepsis [AOR; 2.79 (95%, CI: 1.46-5.35)] and perinatal asphyxia [AOR; 8.25 (95%, CI: 4.23, 16.12)] were found to be determinants of neonatal seizure. Conclusion and recommendations: In this study, neonatal seizure was determined by the factors of neonatal age, gestational age<32 weeks, body temperature >37.5°C, blood glucose level < 40 g/dl, neonatal sepsis, and perinatal asphyxia. Therefore, the presence of such factors requires prompt recognition and treatment. Key words: Seizure, neonates, determinants, case control, Ethiopia.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Alene,

Tsega,

terefe

et al. 2024

Preprint

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“…In our study it was also found that; 69.7% of new-borns had an early-onset seizure which occurs before 72 hours. This finding is comparable to the findings in the study by Shah et al, 9 Rastogi et al's study (66.67%), 4 Dongol Singh et al's study (70.9%), 15 and Baudou et al's study (78%). 18 The explanation is as perinatal asphyxia is the most common comorbidity in those studies and seizures in perinatal asphyxia are usually early onset.…”

Section: Discussionsupporting

confidence: 89%

“… 2 , 3 Neonatal seizures are usually an acute manifestation of disturbance of the developing brain and are common in the early weeks of life. 4 , 5 Despite the prevalence of neonatal seizures admitted to hospitals in Africa, few studies have conducted about the patterns, outcomes of treatments, and their predictors. 6 Neonatal encephalopathy, neonatal sepsis, and premature births in developing countries suggest that the burden may be much higher than the study conducted at a hospital in rural Kenya demonstrated; seizures were documented in 9% of neonatal admissions.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia

Weldegerima,

Gebremariam,

Haftu

et al. 2023

IJGM

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Background Seizure is the most frequently observed symptom of neurological disorders and an important determinant of outcome during neonatal period. In clinical practice, it is prevalent and observed in neonates admitted to hospital in low-resources countries, but due to the paucity of studies in these regions, little is known about its pattern, clinical outcomes of hospitalization, and its predictors. Therefore, aims to evaluate seizure patterns, clinical outcomes, and its predictors among neonates admitted to the NICU of ACSH, Mekelle, and Tigray. Methods A hospital-based cross-sectional study design was conducted among neonates with neonatal seizures admitted to NICU of Ayder Comprehensive Specialized Hospital. Data collection was done from record reviews. SPSS Version 25 was used. Descriptive statistics and bivariate logistic regressions where a p-value of <0.05 is considered statistically significant. Results Out of 1622 NICU admissions, 155 (9.6%) were cases of neonatal seizure. The most frequently observed types of seizure in this study were subtle 70 (45.1%) and tonic 49 (31.6%) respectively. At the end of hospitalization 70.3% of neonates were discharged improved, 21.3% of neonates died and 8.4% of neonates had severe neurologic deficits. Poorly controlled seizures (AOR 4.8, 95% CI 2.6–9.2), prolonged duration of labor (AOR 4.3, 95% CI 2.2–8.8) and seizure onset <72 hours (AOR 3.7, 95% CI 1.6–8.5), respectively, were found to be independent predictors of poor neonatal outcome. Conclusion Of all neonatal admissions, neonatal seizure was observed in close to 9.6%. The most frequently observed type of seizure was subtle. Of those admitted neonates, 30% had poor outcomes following the end of their hospitalization or when they leave against medical advice for lack of improvement). Poorly controlled seizures, prolonged duration of labor, and seizure onset <72 hours were independent predictors of poor neonatal outcomes.

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Incidence and predictors of neonatal seizures among neonates admitted in Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia. A prospective follow-up study

Alemayehu,

Gebre,

Asmare

et al. 2024

Heliyon

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Clinicoetiological Profile of Neonatal Seizures in a Tertiary Care Hospital

Cited by 4 publications

References 8 publications

Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Determinants of neonatal Seizure among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023: A multi-center unmatched case control study.

Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia

Incidence and predictors of neonatal seizures among neonates admitted in Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia. A prospective follow-up study

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