Clinicohaematological profile of Pancytopenia-A South Indiantertiary hospital experience

Tejeswini, Vaddatti; Premalatha, Pidakala; Renuka, .; Krishna, Rajesh; Krichnamacharyulu, Pav; Vahini, Gudeli

doi:10.5958/2394-6792.2015.00013.7

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The present study had a lesser incidence when compared to the study done by Tejeswini et al, with reported incidence of myelofibrosis in 5.2% of cases. 18 Peripheral smear showed leucoerythroblastic blood picture with nucleated RBCs and tear drop cells. Bone marrow aspiration was diluted with peripheral blood.…”

Section: Myelofibrosismentioning

confidence: 99%

A prospective clinico‑hematological study in 100 cases of Pancytopenia in a tertiary care teaching hospital

Regis

Padmavathi

2019

Int J Res Med Sci

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Background: Pancytopenia is encountered regularly in haematology practice, yet there exist only few published assessments of the frequencies of various aetiologies and this exhibit substantial geographic variation. Pancytopenia is a manifestation of many life- threatening diseases with a wide range of differential diagnosis. Haematological investigation forms the bedrock in the detection and management of patients with pancytopenia.Methods: This study is a prospective study conducted in the Institute of pathology and haematology, Madras medical college and Rajiv Gandhi Government General Hospital, Chennai during the period from August 2015 to August 2016 on 100 cases. Case selection is based on clinical features and supported by laboratory evidence. Peripheral smear was obtained and stained by Leishman stain for all cases and examined in detail. Bone marrow aspiration /biopsy was subsequently carried out under aseptic precautions.Results: Among the 100 cases studied, age of the patients ranged from 13 to 80 years with a slight male predominance. Most of the patients presented with generalized weakness and fever. The commonest cause for pancytopenia was aplastic anaemia followed by megaloblastic anaemia. The other causes include acute myeloid leukaemia, myelodysplastic syndrome, myelofibrosis, multiple myeloma, malarial parasite, miliary tuberculosis and osteopetrosis.Conclusions: Pancytopenia can be diagnosed, and its etiological profile can be ascertained with the help of detailed clinical history, meticulous physical examination and haematological investigations. Every attempt should be done to establish the underlying cause so that treatable conditions are diagnosed without delay and prognosis is improved.

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Section: Myelofibrosismentioning

confidence: 99%

A prospective clinico‑hematological study in 100 cases of Pancytopenia in a tertiary care teaching hospital

Regis

Padmavathi

2019

Int J Res Med Sci

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“…The primary contributing factors to the various disorders linked to pancytopenia are geographic variations, genetic mutations, age, sex, and race differences, as well as the prevalence of specific infections in those geographical areas [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Significance of Reticulocyte Count in Assessment of Pancytopenia at Tertiary Care Hospital

Shaikh,

Javed

et al. 2023

PJMHS

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Aim: To determine the significance of reticulocyte count in assessment of pancytopenia. Study Design: Retrospective study Place and Duration: Department of Pathology, Diagnostic and research Laboratory LUMHS, Hyderabad. Jan 2017-Oct 2018. Methods: The study comprised a total of one hundred pancytopneia patients. The comprehensive demographics of the enrolled cases were collected upon obtaining informed written consent. The diagnostic utility of absolute reticulocyte count was determined by correlating it with bone marrow biopsy. SPSS 22.0 was used to analyze the data. Results: Among all, 43% were males and 57% were females. Age of the presented cases was 35.3±2.54 years. 62% patients were married and 37% cases were literate. Majority 59% patients were from rural areas. Megaloblastic anemia was the most common etiology found in 52% cases with reticulocyte count 0.2%, aplastic anemia in 22% cases with reticulocyte count 0.1%, mixed deficiency anemia in 17% reticulocyte count 0.4%, acute leukemia in 6% with reticulocyte count 0.7% and 3% cases had myelodysplastic syndrome with reticulocyte count 0.2%. The most frequent clinical features that were present were pallor (88%), generalized weakness (81%), dyspnea (62%), and fever (60%). Conclusion: Reticulocyte count plays an important role in differentiating various causes of pancytopenia and hence should be routinely included in pancytopenia work up in order to avoid unnecessary bone marrow aspirations. Keywords: Pancytopneia, Reticulocyte count, Fever, Pallor, Biopsy

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Clinicohaematological profile of Pancytopenia-A South Indiantertiary hospital experience

Cited by 2 publications

References 4 publications

A prospective clinico‑hematological study in 100 cases of Pancytopenia in a tertiary care teaching hospital

A prospective clinico‑hematological study in 100 cases of Pancytopenia in a tertiary care teaching hospital

Significance of Reticulocyte Count in Assessment of Pancytopenia at Tertiary Care Hospital

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