Clinicohistopathological correlation of leprosy

Pandya, Amrish N; Tailor, Hemali J.

doi:10.4103/0378-6323.39723

Cited by 21 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4] There was a complete agreement with clinical and histopathological diagnosis with 15 cases. The overall clinicopathological concordance was 53.6% similar to the studies done by Tiwari et al 54%, [4] Janardhan Bommakanti et al 56%, [11] Sharma et al 53.44%, [12] Pandya et al 58.13%, [13] and Mithra et al 53%. [16] Various studies showed clinicopathological concordance from 45.3% to 80.4%.…”

Section: Discussionsupporting

confidence: 76%

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Ebenezer

Chander

Chitra

2018

APALM

View full text Add to dashboard Cite

Background: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. There are various clinico-pathological forms of leprosy depending on the immune status of the host. Diagnosis of leprosy can be done by clinical, microbiological and histopathological examination. Histopathological examination is considered as important for confirmatory diagnosis, for assessment of the disease in patient's under treatment and also for research purposes Methods: A total of 28 skin biopsies of leprosy patients were studied in the Department of Pathology in Saveetha medical college over 7 year's duration (2008 -2015). A Ridley Jopling classification was used for the diagnosis and classification of the disease. All biopsies were stained with haematoxylin and eosin and Fite faraco. Clinico-histopathological correlation was done Result:In this study, number of males (23cases) (82%) were more than the number of females (5 cases) (18%) Mean age of patients was 40 years. The Most common presentation of the lesion was hypopigmented macule involving two areas (13cases). Among 28 cases maximum cases were classified as borderline tuberculoid leprosy (8cases) (28.6%) and least number of cases classified as histiod leprosy (1 case) (3.6%). Fite faraco stain was positive for 3 cases in tuberculoid spectrum and 9 cases in lepromatous spectrum. Conclusion:The current primary goal is early diagnosis of this disease in order to interrupt the transmission by early treatment. Histopathological examination is gold standard in confirmation of its diagnosis and its classification. As new immerging technique become available for the early diagnosis of leprosy, skin biopsies will continue to compliment these for providing more insights into the pathology of this disease.

show abstract

Section: Discussionsupporting

confidence: 76%

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Ebenezer

Chander

Chitra

2018

APALM

View full text Add to dashboard Cite

show abstract

“…19 The commonest histological type in a study by Sharma et al and Rao et al was borderline tuberculoid leprosy and that by Pandya et al was indeterminate leprosy. 6,8,27 In our study, there was complete agreement between the clinical and histopathological diagnosis in 39.58% of the cases. Similar comparative studies by different authors showed complete agreement between clinical and histopathological diagnosis which ranged from 31.58% to 82%.…”

Section: Discussionmentioning

confidence: 66%

“…6 Clinico histopathological examination of leprosy assumes a pivotal role for early diagnosis. 8 Early recognition and treatment limits the damage caused by the disease and renders the person non-infectious and remains the cornerstone of leprosy control. 9 Present study was conducted for clinical and histopathological correlation of skin biopsy which is imperative for diagnosis and classification of disease.…”

mentioning

confidence: 99%

Clinicohistopathological correlation of leprosy

2017

View full text Add to dashboard Cite

BACKGROUND: Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae. It is a spectral disease which is classified into five groups according to Ridley and Jopling based on clinical, histological, microbiological and immunological criteria. Adequate clinical information combined with bacilloscopy and histopathology is helpful not only in classification of different types of leprosy but also useful for management of the cases.METHOD: 50 cases of leprosy were examined and clinical data was recorded. Slit skin smears were stained with Ziehl Neelsen stain. Skin biopsy was stained with Hematoxylin-Eosin stain and Fite Farraco stain was performed to demonstrate acid fast bacilli. All patients were classified according to Ridley & Jopling classification. Clinico-histopathological correlation was done. Statistical analysis was done using SPSS (Statistical Package for the Social Sciences) 16.0.RESULTS: Most common histological type of leprosy was tuberculoid leprosy seen in 19(38%) cases followed by indeterminate leprosy. Overall clinico-histopathological correlation was seen in 39.58%. The correlation was highest in indeterminate and histoid leprosy (100%) followed by lepromatous leprosy (66.66 %%) and tuberculoid leprosy (50%). Slit skin smear showed bacilli in 12 out of 48 cases (25%) while biopsy showed bacilli in 16 out of 48 cases (33.3%).CONCLUSION: In the present study, clinical diagnosis did not correlate with histopathological diagnosis significantly (p value=0.04159). The study emphasizes the role of histopathological and bacilloscopic examination to aid the clinical diagnosis for accurate typing of leprosy cases then better management of the patient.

show abstract

“…The categorisation of leprosy into various types based on microscopic features is important for management of patient, 4,9,13,15 .…”

Section: Discussionmentioning

confidence: 99%

Histopathological Study of Skin Biopsies from Clinically Diagnosed Leprosy Patients – 1 yr Institutional Study

Subhashini¹

2017

JMSCR

View full text Add to dashboard Cite

Clinicohistopathological correlation of leprosy

Cited by 21 publications

References 0 publications

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

India’s Hidden Disease: Retrospective Study Of Hansen Disease In A Tertiary Care Hospital

Clinicohistopathological correlation of leprosy

Histopathological Study of Skin Biopsies from Clinically Diagnosed Leprosy Patients – 1 yr Institutional Study

Contact Info

Product

Resources

About