Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder

Kim, Woo Seok; Jang, Kee–Taek; Choi, Dong Wook; Choi, Sang‐Hoon; Heo, Jin Seok; You, Dong Do; Lee, Hyung Geun

doi:10.1002/jso.21813

Cited by 51 publications

(63 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the present study attempted to compare patients with these different histopathological subtypes to assess the correlation between their clinicopathological characteristics and the PTMA/PTMS expression in SC/ASC and AC of the gallbladder. In the present study, patients with SCC/ASC of the gallbladder accounted for 4.34% (46/1,060) of the total patients with carcinoma of the gallbladder treated at the participating hospitals, which is consistent with the incidence reported in earlier studies (2,6,20). Similar to the clinical presentation of AC, patients with early-stage SCC and ASC presented with no specific symptoms other than those typically associated with chronic cholecystitis, due to which the majority of patients were not diagnosed at an early stage.…”

Section: Discussionsupporting

confidence: 92%

“…The population of the present study mainly included patients with advanced stages of SCC, ASC and AC. Several previous studies have described that SCC and ASC of the gallbladder with a squamous cell component exhibit a greater proliferation capability, lower propensity for metastasis, greater tendency for involvement of adjacent organs, and worse overall prognosis, as compared with that associated with AC of the gallbladder (2)(3)(4)(5)(6). In the present study, no significant difference was observed with respect to the incidence of lymph node metastasis, and invasion of the surrounding tissues and organs between the SCC/ASC and AC groups.…”

Section: Discussionmentioning

confidence: 97%

“…The biological and clinicopathological characteristics of SCC and ASC of the gallbladder are not well-characterized owing to their low incidence. Squamous metaplasia of the gallbladder mucosa or of the pluripotent basal cells in the gallbladder mucus membrane in response to chronic inflammation caused by gallstones has been suggested as the initial event in tumorigenesis (2)(3)(4). In addition, another study observed that SCC and ASC of the gallbladder may result from the exposure to certain carcinogens, including cholanthrene and methylanthracene (5).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prothymosin-α and parathymosin expression predicts poor prognosis in squamous and adenosquamous carcinomas of the gallbladder

Chen

Yang

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

Abstract. The present study aimed to investigate the expression patterns of prothymosin-α (PTMA) and parathymosin (PTMS) in patients with squamous cell carcinoma (SCC), adenosquamous cell carcinoma (ASC) and adenocarcinoma (AC) of the gallbladder, and to assess their association with the clinicopathological characteristics and prognosis of the patients. A retrospective analysis of data pertaining to patients with SCC/ASC (n=46) and AC (n=80) of the gallbladder, who were treated with surgical resection, was conducted. Kaplan-Meier survival analysis was also performed to assess the correlation of the expression pattern with survival. The results revealed a higher percentage of patients with a large tumor diameter (>3 cm) in the SCC/ASC group as compared with those in the AC group (P<0.05). No significant differences were observed between patients with SCC/ASC and those with AC with respect to the patient sex, presence of gallstones, TNM stage, lymph node metastasis, invasive growth into anatomically contiguous structures, surgical methods used, survival rate, and the expression levels of PTMA and PTMA (P>0.05). However, positive expression of PTMA and PTMA was associated with tumor size, TNM stage, lymph node metastasis, locally invasive growth, and treatment with radical resection in patients with SCC/ASC and AC (P<0.05). In addition, positive expression of PTMA and PTMA was observed in a significantly lower number of patients with advanced AC as compared with those in early AC (P<0.05), while these expression levels were also associated with shorter survival in the SCC/ASC group and AC group (P<0.05). Cox multivariate analysis also demonstrated a negative correlation between PTMA and PTMA levels, and the postoperative survival rate in the two groups. In conclusion, the present study indicated that the expression levels of PTMA and PTMA were closely associated with the tumorigenesis and progression of SCC, ASC and AC of the gallbladder. Positive expression of PTMA and PTMA may serve as a valuable prognostic factor in these patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prothymosin-α and parathymosin expression predicts poor prognosis in squamous and adenosquamous carcinomas of the gallbladder

Chen

Yang

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…The OCUG-1 cell line represents a poorly differentiated adenocarcinoma and is regarded as a unique cell line because the corresponding cancer is a transitional form from adenocarcinoma to squamous cell carcinoma (22). Generally, GBC is classified into three histological types: adenocarcinoma, which accounts for 90% of all primary gallbladder cancer cases, followed by squamous carcinoma and adenosquamous carcinoma, both of which display an incidence of 1.4-10.4% (23,24). Although the clinical features of squamous carcinoma and adenosquamous carcinoma are similar to adenocarcinoma of the gallbladder, squamous and adenosquamous carcinoma patients frequently presented with an advanced stage of cancer.…”

Section: Discussionmentioning

confidence: 99%

Galectin-9: An anticancer molecule for gallbladder carcinoma

Tadokoro

Morishita

Fujihara

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

Abstract. Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. There are various histological types of GBC, and the vast majority of GBC cases are adenocarcinomas. Squamous and adenosquamous carcinomas are rare GBC subtypes that are traditionally considered to be more aggressive and to be associated with a poorer prognosis than adenocarcinoma. Galectin-9 (Gal-9), a tandem-repeattype galectin, has been reported to induce apoptosis-mediated elimination of various cancers, including hepatocellular carcinoma, cholangiocarcinoma, and hematologic malignancies. Therefore, we investigated the antitumor effects of Gal-9 on GBC in vitro and in vivo. In our in vitro experiments, Gal-9 suppressed cell proliferation in various GBC cell lines but not in the OCUG-1 cell line, which represents a poorly differentiated type of adenosquamous carcinoma. Gal-9 induced the apoptosis of Gal-9-sensitive GBC cells by increasing the levels of caspase-cleaved keratin 18 and phosphorylated p53. However, Gal-9 did not affect the expression of various cell cycle-related proteins. In addition, Gal-9 suppressed tumor growth by implanted human GBC cells in a xenograft model. Furthermore, Gal-9 induced the phosphorylation of the Ephrin type-B receptor, and the microRNA (miRNA) expression profile was markedly altered by Gal-9. Based on these results, various miRNAs might contribute to the suppression of tumor growth. Our data reveal that Gal-9 suppresses the growth of GBC, possibly by inducing apoptosis and altering miRNA expression. Thus, Gal-9 might serve as a therapeutic agent for the treatment of GBC.

show abstract

“…The major subtype of GBC is adenocarcinoma (AC), which accounts for >90% of GBC cases (1), while squamous cell/adenosquamous carcinoma (SC/ASC) is a rare subtype, comprising 1.4–10.4% of GBC cases (2). Notably, the 5-year survival of patients with GBC involving these two subtypes is extremely low.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Thy1 and ITGA6 is associated with invasion, metastasis and poor prognosis in human gallbladder carcinoma

et al. 2016

View full text Add to dashboard Cite

Gallbladder cancer (GBC) is a rare but highly aggressive cancer for which no well-accepted prognostic biomarkers have been identified. Thymus cell antigen 1 (Thy1), also known as cluster of differentiation (CD)90, and integrin α6 (ITGA6), also known as CD49f, are important molecules in cancer and putative markers of various stem cell types. However, their role in GBC remains to be elucidated. In the present study, Thy1 and ITGA6 expression status in clinical GBC samples, which comprised squamous cell/adenosquamous carcinoma (SC/ASC) and adenocarcinoma (AC) subtypes, was investigated. The associations between Thy1 and ITGA6 expression and clinical parameters and survival rate were analyzed separately. The THY1 and ITGA6 messenger RNA levels were significantly higher in both SC/ASC and AC tissues than in adjacent non-tumor tissues (all P<0.001). These results were subsequently confirmed by immunohistochemical analyses. Overexpression of Thy1 and ITGA6 was correlated with poor differentiation, large tumor size, lymph node metastasis and great invasiveness in SC/ASC (Thy1, P=0.045, P=0.005, P=0.003 and P=0.009, respectively, and ITGA6, P=0.029, P=0.011, P=0.009 and P=0.004, respectively) and AC (Thy1, P=0.027, P<0.001, P=0.003 and P 0.004, respectively, and ITGA6, P=0.002, P=0.003, P=0.006 and P=0.006, respectively). Both Thy1 and ITGA6 were expressed at higher levels in AC with advanced tumor-node-metastasis stage (TNM) than in AC with low TNM stage (P=0.001 and P=0.018, respectively). In addition, patients with elevated Thy1 or ITGA6 expression had shorter overall survival than those with negative Thy1 or ITGA6 expression. Multivariate Cox regression analysis demonstrated that Thy1 (SC/ASC, P=0.001 and AC, P=0.005) and ITGA6 (both P=0.003) were independent predictors of poor prognosis in both SC/ASC and AC patients. In conclusion, Thy1 and ITGA6 could be clinical prognostic markers for GBC.

show abstract

Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder

Cited by 51 publications

References 14 publications

Prothymosin-α and parathymosin expression predicts poor prognosis in squamous and adenosquamous carcinomas of the gallbladder

Prothymosin-α and parathymosin expression predicts poor prognosis in squamous and adenosquamous carcinomas of the gallbladder

Galectin-9: An anticancer molecule for gallbladder carcinoma

Overexpression of Thy1 and ITGA6 is associated with invasion, metastasis and poor prognosis in human gallbladder carcinoma

Contact Info

Product

Resources

About