Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.

Verschraegen, Claire F.; Vasuratna, Apichai; Edwards, Creighton L.; Freedman, Ralph S.; Kudelka, A P; Tornos, Carmen; Kavanagh, John J.

doi:10.3892/or.5.4.939

Cited by 62 publications

(106 citation statements)

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“…Rarely, there is extensive overgrowth of sex cord-like elements within an adenosarcoma. 41,42 Approximately 25% of these tumours may contain heterologous stromal elements, most commonly rhabdomyoblasts and fetal-type cartilage, and rarely lipoblasts. 40 The heterologous elements usually represent a minor component of the stroma, but are occasionally widespread.…”

Section: Pathological Featuresmentioning

confidence: 99%

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A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered.

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Section: Pathological Featuresmentioning

confidence: 99%

“…Sarcomatous overgrowth is typically associated with deep myometrial and vascular invasion, and is the most important prognostic factor. 42 …”

Section: Adenosarcoma With Sarcomatous Overgrowthmentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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“…23 Severity also varies by schema. 24 Studies have shown that malignant cytology is associated with a negative prognosis and a higher rate of recurrent disease. 25 The 7th edition no longer requires peritoneal cytology for staging but continues to recommend its collection as an SSF.…”

Section: Analytic Cohortsmentioning

confidence: 99%

“…Most adenosarcomas are diagnosed as stage I and generally carry a good prognosis. 24,28 Summary of SSFs Of 8 AJCC 7th edition SSFs introduced in 2010 for corpus uteri and corpus, NOS cancer (Table 2), 6 are required by the SEER Program for carcinoma, sarcoma, and adenosarcoma: FIGO stage (SSF1), peritoneal cytology results (SSF2), number of positive pelvic lymph nodes (SSF3), number of pelvic lymph nodes examined (SSF4), number of positive para-aortic lymph nodes (SSF5), and number of para-aortic lymph nodes examined (SSF6). Collection of SSF7 (percentage of non-endometrioid cell type in mixed histology tumors) and omentectomy (SSF8) were recommended by the AJCC but are not required by the SEER Program despite being included in the CAP cancer checklists.…”

Section: Analytic Cohortsmentioning

confidence: 99%

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Site‐specific factors for cancer of the corpus uteri from SEER registries: Collaborative stage data collection system, version 1 and version 2

Jamison

Altekruse

Chang

et al. 2014

Cancer

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BACKGROUND: Uterine cancer is the fourth leading cancer among US women. Changes in uterine cancer staging were made from the American Joint Committee on Cancer (AJCC) 6th to 7th edition staging manuals, and 8 site-specific factors (SSFs) and 3 histologic schemas were introduced. Carcinomas account for 95% of cases and are the focus of this report. METHODS: Distributions of SSF values were examined for 11,601 cases of malignant cancer of the corpus uteri and uterus, NOS (not otherwise specified) diagnosed in Surveillance, Epidemiology, and End Results (SEER) Program registries during 2010. AJCC 6th and 7th edition staging distributions were compared for 11,176 cases using data in both staging systems. AJCC 6th edition staging distributions during 2004-2010 were examined. AJCC 7th edition SSFs required by SEER were International Federation of Gynecology and Obstetrics stage (SSF1), peritoneal cytology (SSF2), number of positive pelvic lymph nodes (SSF3), number of pelvic lymph nodes examined (SSF4), number of positive para-aortic lymph nodes (SSF5), and number of para-aortic lymph nodes examined (SSF6). RESULTS: For SSFs related to lymph nodes, a third of cases were classified as "not applicable," reflecting that lymph node dissection is not indicated for cases with stage1A and stage 4 diagnoses. AJCC 7th edition criteria assigned more cases to stage I (72.9%) than AJCC 6th edition criteria (68.7%). Annual counts significantly increased during 2004-2010, as did counts for AJCC 6th edition stages INOS, IA, IB, IC, IIIA, IIIB, IIIC, and IVB. The proportion of cases diagnosed with stage I cancer was stable, whereas stages II and IV decreased and stage III increased. CONCLUSIONS: Five SSFs were suitable for analysis: peritoneal cytology results (SSF2), numbers of positive pelvic lymph nodes (SSF3), pelvic lymph nodes examined (SSF4), positive para-aortic lymph nodes (SSF5), and para-aortic lymph nodes examined (SSF6). INTRODUCTIONAmong cancers of the female genital system, corpus uteri and corpus, not otherwise specified (NOS) is the most commonly diagnosed cancer and the second most common cause of cancer death after ovarian cancer. Overall, uterine cancer is the fourth most frequently diagnosed cancer among women in the United States, with 49,560 newly diagnosed cases and 8190 deaths estimated to occur during 2013. 1 Incidence rates historically have been slightly higher among white women than black women and women of other races; however, the mortality rate among black women is almost twice that of other women. 2 Factors affecting racial variation include tumor aggressiveness and racial differences in the prevalence of hysterectomy. 3,4 In recent years, the incidence rate of corpus uteri and corpus, NOS cancer has been increasing among women of all major racial and ethnic groups. Estrogen unopposed by progesterone is a main risk factor for endometrial cancer; and the increasing prevalence of obesity is thought to contribute to the recent increase in incidence. 5 Diabetes and nulliparity are both risk factors that ...

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Tumors, Tumor-Like Lesions, and Metaplastic Lesions of the Peritoneum

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.

Cited by 62 publications

References 0 publications

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

Site‐specific factors for cancer of the corpus uteri from SEER registries: Collaborative stage data collection system, version 1 and version 2

Tumors, Tumor-Like Lesions, and Metaplastic Lesions of the Peritoneum

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