Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands

Abstract

MMMT are the most aggressive tumors and their behavior strongly resembles that of high-grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity.

Prognostic Factors and Treatment Outcomes in 93 Patients with Uterine Sarcoma from 4 Centers in Turkey

“…Usually patients with uterine sarcomas are diagnosed at older ages, mean age of our patients was 53.4 (18-80 years) and our MMMT group was older (mean age 61.4). In other studies, similar findings have been reported (Ali & Wells, 1993;Sartori et al, 1997;Park et al, 2008;Benito et al, 2009). Most frequent symptom at presentation was abnormal vaginal bleeding like some other studies (Chavenic et al, 1999;Tsikouras et al, 2008;Benito et al, 2009;D'Angelo & Prat, 2010).…”

“…Patients in MMMT group were mostly postmenopousal (88%), whereas rate of postmenapousal patients in LMS and ESS group were lower (45.1% and 22.2% respectively). This result is convenient with other studies (Benito et al, 2009;D'Angelo & Prat, 2010). Among our patients, the rate of having medical disease in MMMT group was also higher than that of LMS and ESS group (68% versus 40.7% and 33.3%, respectively).…”

“…Our three patients had personal history of other malignancies, Benito et al and Koivisto-Korander et al have been reported higher occurence of previous cancer in this group of patients (Koivisto-Korander et al, 2008;Benito et al, 2009). Patients in MMMT group were mostly postmenopousal (88%), whereas rate of postmenapousal patients in LMS and ESS group were lower (45.1% and 22.2% respectively).…”

“…The histopathological distribution of our patients demonstrated that LMS was most frequent (58%), followed by MMMT (24%). In previously published studies, percentage of LMS and MMMT in all uterine sarcomas reported as 40% and 40% (D'Angelo and Prat, 2010); 22% and 48% (Benito et al, 2009); 33% and 30% (Ghaemmaghami et al, 2008), respectively. Usually patients with uterine sarcomas are diagnosed at older ages, mean age of our patients was 53.4 (18-80 years) and our MMMT group was older (mean age 61.4).…”

“…Most autors found no significant difference in clinical outcome according to histological type except low grade ESS (Salazar & Dunne, 1980;Echt et al, 1990;Wolfson et al, 1994). In some studies, it was reported that MMMT had poorer prognosis than other types (Ghaemmaghami et al, 2008;Benito et al, 2009). Conversely, Olah et al reported that prognosis of LMS was poorer than that of MMMT (Olah et al, 1992).…”