Clinicopathologic and Immunohistochemical Characteristics of Male Breast Cancer: A Single Center Experience

Tawil, Ayman; Boulos, Fouad; Chakhachiro, Zaher; Otrock, Zaher K.; Kandaharian, Loucine; Saghir, Nagi S. El; Saad, George Abi

doi:10.1111/j.1524-4741.2011.01184.x

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…Positively of hormonal receptors is more frequent in men than woman (75-93%) (Davda et al, 2011;Tawil et al, 2011) and our data is comparable to other studies (76.1%, ER or PR positive). P53 expression has been detected in 0-54% of patient with male breast cancer by immunohistochemistry (Davda et al, 2011) and In our patient 4 (19%) were positive for P53.…”

Section: Discussionsupporting

confidence: 91%

“…In the past decade's according to Epidemiology and End results data (SEER), a rise in the incidence of male breast cancer from 1 to 1.2 per 100000 men have been reported from 1970 to 2004 (Speirv andShaaba, 2008). The mean age at diagnosis is 60-67 years in different studies (Tawil et al, 2011), the mean age in our study is 49 years, this lower age correlate with lower age at diagnosis of breast cancer among Iranian woman with breast cancer.…”

Section: Discussionsupporting

confidence: 43%

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Clinicopathologic Characteristics of Male Breast Cancer: A Report of 21 Cases in Radiotherapy Center of Hamedan, Iran

Sedighi¹,

Hamed²,

Mohammadian³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 43%

Clinicopathologic Characteristics of Male Breast Cancer: A Report of 21 Cases in Radiotherapy Center of Hamedan, Iran

Sedighi¹,

Hamed²,

Mohammadian³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The incidence is directly proportional to age. While the age difference between men and women at the time of diagnosis is higher in the USA, this difference is not that high in the Middle East and Southern Asia (22,23). The risk factor of genetic predisposition in men is similar to that of women.…”

mentioning

confidence: 72%

Male Breast Cancer

Yalaza¹,

2016

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IntroductionOver the past two decades, major improvements have been achieved in the understanding of breast cancer, and cure can be offered if the disease is diagnosed at an early stage. However, the disease is more often diagnosed at more advanced stages (3 or 4) in men, in contrast to women. Its rarity among men as well as lack of awareness leads to its detection at later stages. Randomized studies cannot be carried on due to the low incidence of breast cancer in males, with only a few published prospective therapeutic studies in the literature. While the information on male breast cancer (MBC) was obtained from retrospective studies, the recommendations for treatment were derived from studies conducted on female breast cancer (1). This review presents the frequency, etiology, clinical-pathological characteristics and treatment approaches for the rare MBC. Epidemiology-EtiologyMale breast cancer is rare and constitutes 0.5-1% of all patients with breast cancer. The reason of the low incidence rate in men is the relatively low amount of breast tissue along with the difference in their hormonal environment. Even though breast tissue is less in men as compared to women, the factors that influence malignant changes are similar. The Surveillance, Epidemiology and End Result (SEER) Program reported that the incidence of breast cancer was highest at ages 52-71 during 1973-2000, whereas the peak incidence in males was 71 years (2). In fact, some authors state that MBC imitate the behavioral pattern of post-menopausal female breast cancer. The incidence of breast cancer in males and females has increased in the past 25 years. International Association of Cancer Registries (IACR) emphasized this increase and stated that the incidence of female breast cancer increased by 20%, while breast cancer-related deaths increased by 14%. The SEER data also showed that the rate that was 1.1 for 100.000 men in the mid-1970s and raised to 1.44 for 100.000 men by 2010 (3). In USA, 2240 men were diagnosed with breast cancer within the year 2013. The lifetime rate of diagnosis with male breast cancer is 1 in 1000. According to the IACR Turkey data, 0.37% of all cancer types among males are breast cancer (4, 5). IACR has published its new cancer estimates for the year 2012. The most recent cancer estimates for 28 cancer types in 184 countries, which record cancer data, have been made available for users on the GLOBOCAN 2012 website (6).The rate of presentation with advanced stage breast cancer has been decreasing in men. As a matter of fact, a study conducted in 1995 reported the rate of Stage 1-2 disease on diagnosis as 70%, whereas it was reported as 67% in 2010 and 82% in 2015 (7-9). MBC constitutes less than 1% of male cancers and it has a varying rate of incidence across different geographies and ethnic groups (10, 11). Its annual prevalence in Europe is 1 in 10.000 men and these cases constitute less than 1% of all patients with breast cancer (4). However, this rate is above 6% in Central African countries (12). This relatively hig...

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“…The mean age at diagnosis is 67 years (between 60 to 70 years) which is 5 years older than that in women 1 in US, but in other parts of the world such as the Middle East and South Asia, the age gap is smaller. 4,5 As in women, breast cancer in males is also on the rise, the incidence has climbed 26% over the past 25 years. 1 The incidence of MBC in Northwest Europe and North America is approximately 1/100,000.…”

Section: Introductionmentioning

confidence: 99%

Clinical trends and outcomes of male breast cancer: Experience of a tertiary oncology centre in India

Mukherjee

Saha

Chattopadhyay

et al. 2014

Int J Cancer Ther Oncol

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Purpose: Because of its rarity in any oncology centre, the clinical trends of male breast cancer specific to its geographical distribution have remained relatively unexplored. This study was done to analyze the clinico-pathological data, treatment given and survival patterns of male breast cancer patients visiting our tertiary medical centre and compare our results with available literature. Methods: All male breast cancer patients registered at our clinic from 2003 to 2009 were included. Frequency distribution analysis of the demographic and clinico-pathological data and treatment variables was done. Treatment outcome was examined from Kaplan-Meir survival estimates. Results: Thirty-three male breast cancer patients were encountered. The median age of presentation was sixty years. Mostly (87.9%) they presented with lump in breast or axilla and were clinically staged to be '3' (57.6%).Obesity and alcohol were the commonest risk factors identified. Modified radical mastectomy was the commonest (69.6%) definitive therapy rendered with (only for clinically staged 3 patients) or without neo-adjuvant chemotherapy. Infiltrating ductal carcinoma was identified in most cases. Twenty-two patients received adjuvant chemotherapy and twenty-four received adjuvant radiotherapy. Eighteen (54.5%) patients were hormone-receptor positive and received tamoxifen. The median Overall survival (OS) and Progression-free survival (PFS) came out to be 14.3 months (standard error, SE of 1.185; 95% confidence interval, CI 12-16.6) and 15.7 (SE 5.35, 95% CI 5.2-26.19) months respectively. Conclusion: Male breast cancers usually carry a poor prognosis due to presentation at later stages. Most of our results correlate with previous literature. Multi-centric prospective studies are required to validate the etiological factors and prognostic determinants of survival.

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Clinicopathologic and Immunohistochemical Characteristics of Male Breast Cancer: A Single Center Experience

Cited by 15 publications

References 22 publications

Clinicopathologic Characteristics of Male Breast Cancer: A Report of 21 Cases in Radiotherapy Center of Hamedan, Iran

Clinicopathologic Characteristics of Male Breast Cancer: A Report of 21 Cases in Radiotherapy Center of Hamedan, Iran

Male Breast Cancer

Clinical trends and outcomes of male breast cancer: Experience of a tertiary oncology centre in India

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