Clinicopathologic and Molecular Features of 122 Brazilian Cases of Nodal and Extranodal NK/T-Cell Lymphoma, Nasal Type, With EBV Subtyping Analysis

Gualco, Gabrıela; Domeny-Duarte, Pollyanna; Chioato, Lucimara; Barber, Glen N.; Natkunam, Yasodha; Bacchi, Carlos E.

doi:10.1097/pas.0b013e31821ec4b5

Cited by 122 publications

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“…Infiltration of inflammatory cells and necrotic changes are also observed. 1,3 Although it was reported that the background inflammatory cells were composed of various types including histiocytes, 1 to our knowledge, this is the first report in which prominent granulomatous reaction was observed. It was speculated that granulomatous reaction may reflect a host response against tumor and represented a good prognostic factor in mycosis fungoides (MF).…”

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confidence: 86%

Extranodal natural killer/T‐cell lymphoma, nasal type, with prominent granulomatous reaction

Fujimoto¹,

Takahashi²,

Yamashita³

et al. 2014

The Journal of Dermatology

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confidence: 86%

Extranodal natural killer/T‐cell lymphoma, nasal type, with prominent granulomatous reaction

Fujimoto¹,

Takahashi²,

Yamashita³

et al. 2014

The Journal of Dermatology

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“…ENKTL-N is an aggressive NHL with unique epidemiological, etiological and clinical features. Its prevalence is high in Asia and South America, while it is relatively low in North American and European countries [25][26][27][28] . Our previous work indicated that the southwest region of China had a relatively high morbidity of ENKTL-N, which ranked as the second most common lymphoma subtype of all NHL.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Lymphoma in Southwest China: Subtype Distribution of 1,010 Cases Using the WHO (2008) Classification in a Single Institution

et al. 2015

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The gastrointestinal tract (GIT) is the most common anatomic site of extranodal non-Hodgkin lymphoma (NHL) involvement. The classification criteria of lymphoma have changed in recent decades, and few large-sample studies regarding subtype analysis of lymphoma have been performed in this site. Aim: Therefore, the present study was conducted to analyze the histological subtype distribution of the GIT. Method: All patients in a single institution with a diagnosis of primary NHL in the GIT were enrolled between January 2007 and April 2014. The patients were categorized according to the WHO (2008) classification of tumors of hematopoietic and lymphoid tissue. Result: A total of 1,010 eligible cases diagnosed as NHL were collected in this study. The male:female ratio was 1.7:1 and the median age was 55 years. The percent of patients with lymphoma involvement in the stomach was 52% (n = 522), and the remaining 48% (n = 484) had intestinal tract involvement. Histologically, diffuse large B cell lymphoma (DLBCL) was the most common subtype in all of the GIT lymphoma cases, and was also the most common subtype in cases involving the stomach (78%) and the intestinal tract (53%). The incidence of DLBCL and mucosa-associated lymphoid tissue lymphoma in the stomach was significantly higher than the incident in the intestinal tract (p < 0.01). T and NK cell lymphoma was significantly more common in the intestinal tract than in the stomach (p < 0.01). Extranodal NK/T cell lymphoma nasal type (ENKTL-N) was the most common subtype of T and NK cell lineage lymphoma in GIT and was also the second most common intestinal tract-involved lymphoma. Conclusion: DLBCL was the most frequent lymphoma in the stomach and in the intestinal tract. T and NK cell lineage lymphoma had a higher occurrence in the intestinal tract than in the stomach. ENKTL-N was the most frequent subtype of lymphoma derived from NK/T cell lineage, and was the second most common lymphoma among all intestinal tract lymphomas.

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“…[2][3][4]7 Moreover, comparison of the incidence rates and frequency patterns of specific NHL subtypes may provide critical clues to guide future epidemiologic studies. 3 Although studies of individual NHL subtypes have been conducted in several Central and South American (CSA) countries, [13][14][15][16] in only a few epidemiologic studies have authors examined the distribution of NHL subtypes in individual countries. [17][18][19] However, to our knowledge, a large-scale, wellorganized, systematic study of the distribution of NHL subtypes in CSA has not been undertaken.…”

Section: Introductionmentioning

confidence: 99%

Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases

Laurini

Perry

Boilesen

et al. 2012

Blood

141

111

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The distribution of non-Hodgkin lymphoma (NHL) subtypes differs around the world but a systematic study of Latin America has not been done. Therefore, we evaluated the relative frequencies of NHL subtypes in Central and South America (CSA). Five expert hematopathologists classified consecutive cases of NHL from 5 CSA countries using the WHO classification and compared them to 400 cases from North America (NA). Among the 1028 CSA cases, the proportions of B-and T-cell NHL and the sex distribution were similar to NA. However, the median age of B-cell NHL in CSA (59 years) was significantly lower than in NA (66 years; P < .0001). The distribution of high-grade (52.9%) and low-grade (47.1%) mature B-cell NHL in CSA was also significantly different from NA (37.5% and 62.5%; P < .0001). Diffuse large B-cell lymphoma was more common in CSA (40%) than in NA (29.2%; P < .0001), whereas the frequency of follicular lymphoma was similar in Argentina (34.1%) and NA (33.8%), and higher than the rest of CSA (17%; P < .001). Extranodal NK/Tcell NHL was also more common in CSA (P < .0001). Our study provides new objective evidence that the distribution of NHL subtypes varies significantly by geographic region and should prompt epidemiologic studies to explain these differences. (Blood. 2012;120(24):4795-4801) IntroductionNeoplasms of the lymphoid system are very diverse with different clinical presentations, morphologic appearances, and biologic behaviors. 1 Furthermore, the non-Hodgkin lymphoma (NHL) category includes numerous different subtypes. The incidence of NHL is increasing worldwide and, although this increase began to slow in the 1990s, significant variations in temporal trends have been noted for individual NHL subtypes. 2,3 Epidemiologic studies of risk factors for NHL have contributed significantly to our understanding of the pathogenesis of these neoplasms. [2][3][4][5] In numerous epidemiologic studies investigators also have analyzed the distribution of NHL subtypes in North America (NA), Europe, the Far East, and Middle East. 3,[6][7][8][9][10][11][12] These studies have shown substantial differences in the relative frequencies of NHL subtypes in different geographic regions. Furthermore, it has become clear that subtype-specific NHL frequency patterns in different geographic regions may be indicative of environmental or host risk factors in a particular region. [2][3][4]7 Moreover, comparison of the incidence rates and frequency patterns of specific NHL subtypes may provide critical clues to guide future epidemiologic studies. 3 Although studies of individual NHL subtypes have been conducted in several Central and South American (CSA) countries, [13][14][15][16] in only a few epidemiologic studies have authors examined the distribution of NHL subtypes in individual countries. [17][18][19] However, to our knowledge, a large-scale, wellorganized, systematic study of the distribution of NHL subtypes in CSA has not been undertaken. The aim of this study was to assess the clinical features and distribution of NHL su...

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Clinicopathologic and Molecular Features of 122 Brazilian Cases of Nodal and Extranodal NK/T-Cell Lymphoma, Nasal Type, With EBV Subtyping Analysis

Cited by 122 publications

References 0 publications

Extranodal natural killer/T‐cell lymphoma, nasal type, with prominent granulomatous reaction

Extranodal natural killer/T‐cell lymphoma, nasal type, with prominent granulomatous reaction

Gastrointestinal Lymphoma in Southwest China: Subtype Distribution of 1,010 Cases Using the WHO (2008) Classification in a Single Institution

Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases

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