Clinicopathologic characteristics and prognosis of young patients with breast cancer

Han, Jiguang; Jiang, Yongdong; Zhang, Chunhui; Pang, Da; Zhang, Ming; Wang, Yanbo; Wang, Handong; Sun, Qian

doi:10.1016/j.breast.2011.02.011

Cited by 24 publications

(17 citation statements)

References 21 publications

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“…The BT and BC survivors in this study are similar to those in other studies in terms of age, gender, disease severity, and treatment [10,[34][35][36][37][38]. The median time since diagnosis was just over 2 years with established impairments and functional disability.…”

Section: Discussionsupporting

confidence: 79%

Supportive Care Needs following Cancer Treatment: A Comparison of Breast and Brain Cancer in an Australian Cohort

Amatya

Khan

et al. 2014

ISRN Rehabilitation

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Objective. To assess and identify patient-reported supportive care needs following definitive treatment in persons with breast cancer (BC) and primary brain tumours (gliomas) (BT) in an Australian community cohort and to assess the commonalities and/or discrepancies of the reported needs in these oncological populations. Methods. A prospective cross-sectional survey of persons with BC ( = 85) and BT ( = 106) using questionnaires for supportive care needs, psychological morbidity, and quality of life. Results. BT participants were younger than BC patients (mean ages 51 and 57 years). The median time since diagnosis for both groups was over 2 years. The level of psychological morbidity, mainly depression, was high in both groups: BC (22%) and BT (20%). Participants in both groups reported at least one need ("met" or "unmet"). The BC patients reported higher numbers of "needs" and "unmet" needs compared with BT patients (mean 13.7 versus 11.6 needs; "unmet" needs mean 6.0 versus 4.1). The common "met" and "unmet" needs highlighted by both groups were comparable; the domain for most "met" needs included comprehensive cancer care, while "unmet" needs related to existential survivorship issues. Conclusion. Despite successful treatment many cancer survivors experience unmet supportive care needs in longer term. Understanding the impact of these beyond the acute phase is important as care shifts to community settings. More research in existential survivorship issues is needed.

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Section: Discussionsupporting

confidence: 79%

Supportive Care Needs following Cancer Treatment: A Comparison of Breast and Brain Cancer in an Australian Cohort

Amatya

Khan

et al. 2014

ISRN Rehabilitation

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“…Breast cancer mortality rates declined about 2% per year over the period 1998 through 2009 (Smith et al, 2014). In addition to government "one-child" policy and the insufficient medical financial appropriation (Lu et al, 2010), Chinese women have their unique physiological features and epidemiological characteristics compared with women in some western developed countries (Han et al, 2011;Li et al, 2011). These lead to a controversy on the application of mammography as a single screening modality for Chinese women in the developing country.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Mammographic Breast Density in a Group of Screening Chinese Women and Breast Cancer Patients

Liu¹,

Liu²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: A dense breast not only reduces the sensitivity of mammography but also is a moderate independent risk factor for breast cancer. The percentage of Western women with fat breast tissue is higher aged 40 years or older. To a certain extent, mammography as a first choice of screening imaging method for Western women of this group is reasonable. Hitherto, the frequency and age distribution of mammographic breast density patterns among Chinese women had not been characterized. The purpose of this study was to investigate the frequency and age distribution of mammographic breast density patterns among a group of Chinese screening women and breast cancer patients in order to provide useful information for age-specific guidelines for breast cancer screening in Chinese women. Methods: A retrospective review of a total of 3,394 screening women between August and December 2009 and 2,527 breast cancer patients between July 2011 and June 2012 was conducted. Descriptive analyses were used to examine the association between age and breast density. The significance of differences of breast density between the screening women and the breast cancer patients was examined using nonparametric tests. Results: There was a significant inverse relationship between age and breast density overall (r=-0.37, p< 0.01). Breast density of the breast cancer patients in the subgroups of 40-49 years old was greater compared with that of the screening women, the same in those aged 50-54 years and in those 55 years old or older, less than in the screening group. Conclusions: With regard to the Chinese women younger than 55 years old, the diagnostic efficiency of breast cancer screening imaging examinations may be potentially improved by combining screening mammography with ultrasound.

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“…Furthermore, mammography provides an overall view of the breast and facilitates for contrast of the bilateral breasts especially in women with relatively large breasts. However, Chinese patients have their unique physiological features: relatively smaller breasts with denser breast tissue, and an earlier age (before menopause) to contract breast cancer (Fan et al, 2009;Han et al, 2011), as compared to women with breast cancer in western countries. Our data revealed that the mean age of the 306 cases was 51 years, the average breast volume was 528.9 ml, and patients with high-density breast tissue accounted for 82%, which further confirmed Chinese patients' different physiological and epidemiological characteristics from women in western countries.…”

Section: Discussionmentioning

confidence: 99%

“…As compared with cases in some western countries, patients with breast cancer in Asia including China have their unique epidemiological characteristics and physiological features. For example, there are more patients diagnosed at the younger age, and the density of mammary tissue is higher (Fan et al, 2009;Lee et al, 2009;Han et al, 2011;Li et al, 2011). This leads to the controversy on the application of mammography.…”

Section: Introductionmentioning

confidence: 99%

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Wang¹,

Chen²,

Yin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Mammography has been confirmed as the only effective mode to improve the prognosis of patients with breast cancer in Western developed countries, but might not be a good choice in other areas of the world. One of the major challenges in China is to determine an optimal imaging modality for breast cancer screening. This study was designed to clarify the sensitivity of ultrasonography compared with that of mammography in rural China. Methods: We retrospectively studied the sensitivity of mammography and ultrasonography based on 306 breast cancer patients detected by the program of "screening for cervical cancer and breast cancer" performed in Chinese rural areas between January 2009 and December 2011, and analyzed the effects of age, breast density and volume on the sensitivity. Results: Stratified analysis showed that the sensitivity of breast ultrasonography was significantly higher than that of mammography in premenopausal patients (81.4% vs. 61.1%, p=0.02), in women ≤ 55 years of age (82.2% vs. 63.4%, p<0.01), in the high breast density group (American College of Radiology [ACR] levels 3-4) (85.9% vs. 60.6%, p<0.01) and in the small breast volume group (≤400 ml) (87.1% vs. 66.7%, p<0.01). Age had a significant effect on sensitivity of mammography (breast density and volume-adjusted odds ratio, 6.39; 95% confidence interval, 2.8-14.4 in age group > 55 compared to age group ≤ 45), but not that of ultrasonography. Neither breast density nor volume had significant effect on sensitivity of mammography or ultrasonography. Conclusions: Ultrasonography is more sensitive than mammography in detecting breast cancer in women under 55 year-old Chinese, especially in those with high-density and relatively small breasts.

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Clinicopathologic characteristics and prognosis of young patients with breast cancer

Abstract: Compared with patients aged between 35 and 50 years, patients aged <35 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis.

Cited by 24 publications

References 21 publications

Supportive Care Needs following Cancer Treatment: A Comparison of Breast and Brain Cancer in an Australian Cohort

Supportive Care Needs following Cancer Treatment: A Comparison of Breast and Brain Cancer in an Australian Cohort

Analysis of Mammographic Breast Density in a Group of Screening Chinese Women and Breast Cancer Patients

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

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