Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project

Federico, Massimo; Rüdiger, Thomas; Bellei, Monica; Nathwani, Bharat N.; Luminari, Stefano; Coiffier, Bertrand; Harris, Nancy L.; Jaffe, Elaine S.; Pileri, Stefano; Savage, Kerry J.; Weisenburger, Dennis D.; Armitage, Jamés O.; Mounier, Nicolas; Vose, Julie M.

doi:10.1200/jco.2011.37.3647

Cited by 312 publications

(370 citation statements)

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“…Reports of the development of clonal T-cell proliferation mimicking AITCL in chronic immunosuppressive condition suggest a role of the underlying immune defect in the pathogenesis of AITCL [22,23]. These patients usually exhibit an aggressive clinical course and show a dismal outcome with the current therapies [24]. In accordance with pathological findings, the gene expression profile of AITCL shows a specific TFH cell signature and a strong microenvironment imprint [25].…”

Section: (4)supporting

confidence: 57%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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Section: (4)supporting

confidence: 57%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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“…The current World Health Organization classification system (3) recognizes 13 PTCL subtypes; however, some of the major PTCL subtypes, including PTCL-NOS and ALCL, are themselves thought to comprise heterogeneous entities (4)(5)(6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Peripheral T-Cell Lymphomas: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

et al. 2014

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“…BM examination revealed infiltration by lymphoma cells. Patient was high risk by Prognostic index for AITL [2], (4/5 risk factors).…”

Section: Case Reportmentioning

confidence: 99%

A Synchronous Presentation of AITL with Adenocarcinoma of Lung

Karunakaran¹

2016

Int J Immunother Cancer Res

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Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T -cell lymphoma (PTCL) characterized by generalized lymphadenopathy, hepatosplenomegaly, and frequent Bsymptoms. Extranodal manifestations are quite common in this subtype of Non Hodgkins Lymphoma which is characterized by frequent skin involvement. However, the extranodal disease should be evaluated thoroughly and a tissue diagnosis must be obtained to confirm lymphomatous involvement when the presentation is not classical. Here we report a case of AITL who presented with lung mass suspected to be due to lymphomatous involvement, but turned out to be a synchronous presentation of an adenocarcinoma of the lung. The possible relation between the two conditions is also elucidated.

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Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project

Cited by 312 publications

References 36 publications

Peripheral T cell lymphoma in Asia

Peripheral T cell lymphoma in Asia

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Peripheral T-Cell Lymphomas: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

A Synchronous Presentation of AITL with Adenocarcinoma of Lung

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