Clinicopathologic characteristics of Nocardia brain abscesses: Necrotic and non-necrotic foci of various stages

Kisiel, Marta; Bass, Victoria M.; Fong, Crystal; Graham, Alice K.; Yahya, Sultan; Eichorn, Frances-Claire; Lannon, Melissa; Kameda-Smith, Michelle; Reddy, Kesava K.V.; Lu, Jian-Qiang

doi:10.1016/j.jns.2023.122850

Journal of the Neurological Sciences

2024

DOI: 10.1016/j.jns.2023.122850

|View full text |Cite

Clinicopathologic characteristics of Nocardia brain abscesses: Necrotic and non-necrotic foci of various stages

Marta Kisiel,

Victoria M. Bass,

Crystal Fong

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Polymicrobial brain abscesses: A complex condition with diagnostic and therapeutic challenges

Eichorn,

Kameda-Smith,

Fong

et al. 2024

Journal of Neuropathology &Amp; Experimental Neurology

View full text Add to dashboard Cite

Brain abscesses (BA) are focal parenchymal infections that remain life-threatening conditions. Polymicrobial BAs (PBAs) are complex coinfections of bacteria or bacterial and nonbacterial pathogens such as fungi or parasites, with diagnostic and therapeutic challenges. In this article, we comprehensively review the prevalence, pathogenesis, clinical manifestations, and microbiological, histopathological, and radiological features of PBAs, as well as treatment and prognosis. While PBAs and monomicrobial BAs have some similarities such as nonspecific clinical presentations, PBAs are more complex in their pathogenesis, pathological, and imaging presentations. The diagnostic challenges of PBAs include nonspecific imaging features at early stages and difficulties in identification of some pathogens by routine techniques without the use of molecular analysis. Imaging of late-stage PBAs demonstrates increased heterogeneity within lesions, which corresponds to variable histopathological features depending on the dominant pathogen-induced changes in different areas. This heterogeneity is particularly marked in cases of coinfections with nonbacterial pathogens such as Toxoplasma gondii. Therapeutic challenges in the management of PBAs include initial medical therapy for possibly underrecognized coinfections prior to identification of multiple pathogens and subsequent broad-spectrum antimicrobial therapy to eradicate identified pathogens. PBAs deserve more awareness to facilitate prompt and appropriate treatment.

show abstract

Polymicrobial brain abscesses: A complex condition with diagnostic and therapeutic challenges

Eichorn,

Kameda-Smith,

Fong

et al. 2024

Journal of Neuropathology &Amp; Experimental Neurology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clinicopathologic characteristics of Nocardia brain abscesses: Necrotic and non-necrotic foci of various stages

Cited by 1 publication

References 29 publications

Polymicrobial brain abscesses: A complex condition with diagnostic and therapeutic challenges

Polymicrobial brain abscesses: A complex condition with diagnostic and therapeutic challenges

Contact Info

Product

Resources

About