Clinicopathologic Characteristics of Papillary Microcarcinoma in the Elderly

김원진,; 배민정,; 이양선,; Jeon, Yun Kyung; Soo, Kenneth; Kim, Bo‐Hyun; Kim, In Joo

doi:10.11106/jkta.2013.6.1.69

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The variants reported in young PTC patients include the diffuse sclerosing variant (41.2%, predominant), conventional PTC (38.2%), follicular (2.9%), and cribriform-morular variants (1.5%) 10. PTC in young patients is more likely to have ETE (62.3%), lymph node metastasis (72%), and distant metastasis (23%) than that in adults: adults have ETE (31.2-33%) and lymph node metastasis (32.1-40.9%) 12. The most common metastatic site is the lung (16.2%).…”

Section: Discussionmentioning

confidence: 99%

“… 10 PTC in young patients is more likely to have ETE (62.3%), lymph node metastasis (72%), and distant metastasis (23%) than that in adults: adults have ETE (31.2-33%) and lymph node metastasis (32.1-40.9%). 12 The most common metastatic site is the lung (16.2%). In view of these aggressive features at the time of diagnosis, closer and more extensive workups should be performed in young patients than in elder patients to ensure exact diagnosis and appropriate early management.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review

et al. 2014

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Papillary thyroid carcinoma (PTC) in children under ten years old is very rare. To date, 18 cases of PTC in children under ten years old (including our two cases) have been reported in Korea. Here, we describe two cases of recurrent PTC with follicular variant and conventional type in an 8-year-old boy and a 7-year-old boy, respectively, and discuss clinicopathologic and molecular characteristics that differ in pediatric patients from adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review

et al. 2014

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“…Микрокарциномы щитовидной железы определятся согласно классификации ВОЗ как папиллярные раки щитовидной железы до 1 см в наибольшем размере [1]. В связи с широким применением в клинической практике тонкоигольной аспирационной биопсии (ТАПБ), микрокарциномы стали составлять около 40 % [2], по данным отдельных авторов -до 61,48 % [3] от диагностируемых раков ЩЖ. До сих пор продолжает быть актуальным исследование характера течения микрокарцином ЩЖ.…”

Section: Introductionunclassified

Ethelial-mesenchymal transformation of papillary thyroid mcrocarcinomas

Яковцова¹,

Ивахно²,

Долгая³

et al. 2015

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В 28 случаях папиллярных микрокарцином щитовидной железы выявлено повышение экспрессии виментина в зонах инвазии (р<0,01) и метастазах (<0,001). Для микрокарцином с выраженной экспрессией виментина трабекулярно-солидного строения характерно повышение уровня экспрессии ММР-9 (р<0,005), VEGF (р<0,05), снижение уровня экспрессии NIS (р<0,005), метастазирование в регионарные лимфатические узлы (р<0,001) Ключевые слова: папиллярные микрокарциномы щитовидной железы, эпителиально-мезенхимальная трансформация, метастазы в лимфатические узлы Epithelial-mesenchymal transformation (EMT) in papillary thyroid cancer results in high risk of invasion and lymph node metastasizes. The aim of the study was to investigate the immunohistochemical features of EMT in papillary thyroid microcarcinomas (PTM) for identify morphological diagnostic features of tumor aggressive clinical behavior. Methods. The immunohistochemical expression patterns of vimentin were examinated in central regions, invasion zones and lymph node metastases in 28 patients with PTM. It is investigated an expression of NIS, VEGF, MMP-9 and pan-cytokeratin in PTM with solid/trabecular pattern of growth and high level expression of vimentin. Results. It is shown that microcarcinomas with high level expression of vimentin, exhibiting a solid/trabecular pattern of growth associated with increase MMP-9 (p<0,005), VEGF (р<0,05), and decrease NIS (р<0,005) level expression. These changes reflect phenotype of the epithelial-mesenchymal transformation and associated with the presence of metastases in cervical lymph nodes (p<0,001). Conclusions. Epithelial-mesenchymal transformation which can be seen under routine H&E observation is an important indicator of lymph node metastasis of PTM

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Central Lymph Node Metastasis Is an Important Prognostic Factor in Patients with Papillary Thyroid Microcarcinoma

2014

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Papillary thyroid microcarcinoma (PTMC) has been increasing, without a consensus for the management of this condition. In the present study, we analyzed the clinicopathological features of patients with PTMC to examine the impact of initial therapy and establish appropriate treatment. A total of 2,018 patients with PTMC were enrolled at a single university hospital. Of them, 1,245 patients (61.8%) underwent total thyroidectomy, and 1,838 patients (91.3%) underwent central lymph node (LN) dissection. Five-and 10-yr recurrence rates were 3.2% and 4.6%, respectively. In univariate analysis, the prognostic factors for recurrence were N stage, the number of LN metastases, and extrathyroidal extension. However, multivariate analysis revealed LN metastases and N stage as the only significant prognostic factors after adjusting for confounding factors (P < 0.001). Additionally, multivariate analysis of a subgroup consisting of PTMC patients without N1b revealed the number of central LN metastases as the only significant factor. Therefore, intraoperative examination for central LN metastasis may discriminate high or low risk group.

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Clinicopathologic Characteristics of Papillary Microcarcinoma in the Elderly

Cited by 4 publications

References 29 publications

Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review

Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review

Ethelial-mesenchymal transformation of papillary thyroid mcrocarcinomas

Central Lymph Node Metastasis Is an Important Prognostic Factor in Patients with Papillary Thyroid Microcarcinoma

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