Clinicopathologic Characteristics of Pregnancy-Associated Breast Cancer: Results of Analysis of a Nationwide Breast Cancer Registry Database

Kim, Yun Gyoung; Jeon, Ye Won; Ko, Byung Kyun; Sohn, Guiyun; Kim, Eun‐Kyu; Moon, Byung‐In; Youn, Hyun Jo; Kim, Hyun-Ah

doi:10.4048/jbc.2017.20.3.264

Cited by 24 publications

(34 citation statements)

References 9 publications

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“…Compared to nulliparous women, women with PABC, especially those diagnosed in the first year after delivery, presented a more advanced and aggressive stage of cancer and higher proportions of ER − , PR − , HER2 + and triple‐negative tumors . Hormone receptor‐negative cells were frequently observed in PABC patients compared to those in non‐PABC patients . PABC remains an understudied but important and growing clinical problem worldwide.…”

Section: Discussionmentioning

confidence: 99%

Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer

et al. 2018

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The initiation of spontaneous breast cancer (SBC) in Tientsin Albino 2 (TA2) mice is related to mouse mammary tumor virus (MMTV) infection, and MMTV amplification is hormonally regulated. To explore the insertion site of MMTVLTR in TA2 mouse genome, reverse PCR and nested PCR were used to amplify the unknown sequence on both sides of the MMTV‐LTRSAG gene in SBC and normal breast tissue of TA2 mice. Furthermore, the clinicopathological significance of the insertion site was evaluated in 43 samples of normal breast tissue, 46 samples of breast cystic hyperplasia, 54 samples of ductal carcinoma in situ, 142 samples of primary breast cancer and 47 samples of lymph node metastatic breast cancer by RNA in situ hybridization. We confirmed that the insertion site of the MMTV‐LTRSAG gene was located between Igκv2‐112 and Igκv14‐111 in chromosome 6 of TA2 mouse. IG κC was localized in the stromal cells of TA2 mouse with SBC and in human breast cancer tissues. Tumor cells were negative for IG κC in RNA in situ hybridization. The positive staining index of IG κC in stromal cells was the highest in lymph node metastatic breast cancer, followed by primary breast cancer, ductal carcinoma in situ, and breast cystic hyperplasia. Furthermore, the positive staining index of IG κC was related to the expression of ER, PR, HER2 and Ki‐67. Our findings showed that stromal IG κC expression was associated with the initiation of SBC in TA2 mice. IG κC may be a high‐risk factor for the initiation and progression of human breast cancer.

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Section: Discussionmentioning

confidence: 99%

Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer

et al. 2018

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“…Only three East Asian studies have examined this problem . One study collected data from a hospital in northern Taiwan from 2004 to 2009 .…”

Section: Introductionmentioning

confidence: 99%

“…Those who had a full‐term pregnancy in the previous 5 years had a 1.62‐times higher risk of breast cancer recurrence. Finally, a Korean study identified 344 breast cancer patients, including ductal carcinoma in situ, diagnosed during pregnancy or within 1 year after delivery and 668 age‐, operation‐, and stage matched nonpregnancy‐related breast cancer patients treated between 1989 and 2012 . The authors found a significantly lower survival rate for pregnancy‐related breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

“…14,17,18 Only three East Asian studies have examined this problem. [19][20][21] One study collected data from a hospital in northern Taiwan from 2004 to 2009. 19 The investigators found similar overall survival among patients who were diagnosed during pregnancy (n = 15), 1 year after delivery (n = 11), and nonpregnancyrelated patients (n = 104).…”

Section: Introductionmentioning

confidence: 99%

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Association of pregnancy and mortality in women diagnosed with breast cancer: A Nationwide Population Based Study in Taiwan

Chuang

Lin

et al. 2018

Intl Journal of Cancer

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We examined the associations between breast cancer diagnosed during pregnancy and up to 5 years postpartum and total mortality. Breast cancer patients were identified from the Taiwan Cancer Registry (2002-2014). All pregnancies up to 5 years before breast cancer diagnosis were abstracted from the National Health Insurance database and data were then linked to the Taiwan National Death Certificate Database. Follow-up was calculated from the date of breast cancer diagnosis to the date of death or 31 December, 2014, whichever came first. The hazard ratios (HRs) and the 95% confidence intervals (CI) of the association between pregnancy and total mortality were estimated using Cox proportional hazard models. Among the 30,230 breast cancer patients, 90 were diagnosed during pregnancy, 347 within a year postpartum, and 1993 during 1-5 years postpartum. By the end of 2014, 2,920 patients were dead. The major cause of death was breast cancer (89%). Compared to patients without pregnancy records, the HRs were 1.42 (95% CI = 0.83-2.45) for patients diagnosed during pregnancy, 1.29 (0.96-1.74) for those diagnosed within a year postpartum, 1.27 (0.95-1.70) for those diagnosed within 1 to 2 years postpartum, and 1.06 (0.88-1.27) for those diagnosed ≥2 to 5 years postpartum, after adjustment for tumor characteristics and treatment. Subgroup analyses revealed an increased risk of mortality for patients diagnosed within a year postpartum in ER+ cancers (HR = 2.11, 95% CI = 1.28-3.47). Our results suggested a recent pregnancy may be associated with higher mortality among ER+ patients.

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“…The survival rates of the PABC patients compared to those of the non-PABC patients were conflicting. Most studies [8,9,15,10,14,[16][17][18][19][20][21][22]] demonstrated a worse prognosis in PABC after excluding prognostic factors, including age, the tumor size, and lymph node status, while eight studies [23][24][25][26][27][28][29][30] showed no difference in survival between PABC and non-PABC patients after correcting for these factors.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Survival of Pregnancy-Associated Breast Cancer: A Retrospective Study of 203 Cases in China

Han

Zhao

et al. 2020

Preprint

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Purpose: Pregnancy-associated breast cancer (PABC) is an aggressive disease, and sinceChinese authoritybegan to encourage childbearing in 2015, the incidence of PABC has increased. This study investigated the characteristics and survival of PABC patients. Methods: Patients with PABC who underwent surgery at Fudan University, Shanghai Cancer Center between 2005 and 2018 were enrolled.Data concerning the tumor characteristics, maternal state (whether first or non-first pregnancy ) and survival outcome were recorded. Pearson Chi-square tests were used to compare the characteristics of the tumors, and Kaplan-Meier methods were used to perform the survival analysis. Results: Overall, 203 PABC patients were recruited. Since 2015, 65.5% of non-first pregnant women were diagnosed with breast cancer, it’s 5.7 fold of the incidence of PABC in non-first pregnant women. No significant differences in tumor characteristics were observed between the patients who were in their first pregnancy and those in non-first pregnancy. Among the entire PABC population, luminal B breast cancer accounted for the largest proportion (38.4%), followed by triple-negative breast cancer (TNBC, 30.0%). The distribution of the molecular subtypes of PABC and non-PABC differed (P<0.001) as follows: in the PABC patients, Luminal B 38.4%, Triple negative breast cancer (TNBC) 30.1%, Human Epidermal Growth Factor Receptor 2 (HER-2) overexpression 15.8%, and Luminal A 10.8%; in the non-PABC patients, Luminal A 50.9%, Luminal B 20.1%, TNBC 17.4%, and HER-2 overexpression 8.0%. The 3-year disease free survival (DFS) of all PABC patients was 80.3%. The 3-year DFS of the patients in the first-pregnancy group was 78.4%, and that of the patients in the non-first-pregnancy group was 83.7% (P=0.325). Conclusions: Our study proved that the proportion of women who developed PABC during the second or third pregnancy was extremely high relative to the newborn populations. The patients in the PABC population tended to present more luminal B and TNBC breast cancer than the non-PABC patients.

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Clinicopathologic Characteristics of Pregnancy-Associated Breast Cancer: Results of Analysis of a Nationwide Breast Cancer Registry Database

Cited by 24 publications

References 9 publications

Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer

Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer

Association of pregnancy and mortality in women diagnosed with breast cancer: A Nationwide Population Based Study in Taiwan

Clinical Features and Survival of Pregnancy-Associated Breast Cancer: A Retrospective Study of 203 Cases in China

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