Clinicopathologic characteristics of primary vaginal clear cell carcinoma in China and an endometriosis malignant transformation case: a case series

Abstract

To the Editor: Primary vaginal carcinoma is a rare malignant disease, which represents only approximately 1% to 2% of female genital malignancies. Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, and is associated with a high risk of vaginal carcinoma. In women prenatally exposed to diethylstilboestrol (DES), vaginal adenosis may arise in up to 90%, and these are often associated with vaginal clear cell adenocarcinoma. [1] DES is an orally active non-steroidal estrogen. The Food and Drug Administration began a clinical trial in 1943, and concluded that DES administration is beneficial for preventing premature deliveries and miscarriages. [2] In addition to primary vaginal clear cell carcinoma (PVCCC), in-uterus exposure to DES can also lead to T-shaped uterus anomaly. [3] In the Chinese population, PVCCC is an uncommon malignancy, and there are no reports on the relationship between PVCCC and DES exposure. [4] Given the rarity of PVCCC, it is significant to analyze relevant cases, and provide some valuable information for future clinical and basic studies. Therefore, the present study described ten cases of PVCCC, and summarized the characteristics of the diagnosis, management, and prognosis of these patients.A total of 228 patients were diagnosed with vaginal malignancy. Furthermore, 11 patients were diagnosed Sikai Chen and Zhiyue Gu contributed equally to this work.

A rare case of combined endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrical deep endometriosis

“…Other locations also include the intestine, abdominal wall, vagina, cervix, bladder, ureter, pelvic oor muscles, and recto-vaginal septum. [2][3][4] [5][6] [7] Malignant transformation from adenomyosis is extremely rare. [8] [9][10] [11] The most common malignant pathological type in ectopic endometrium is endometrioid adenocarcinoma.…”