Clinicopathologic comparison between sporadic and syndromic Peutz-Jeghers polyps

Liu, Bella Lingjia; Ward, Stephen C.; Polydorides, Alexandros D.

doi:10.1016/j.humpath.2023.09.008

Human Pathology

2023

DOI: 10.1016/j.humpath.2023.09.008

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Clinicopathologic comparison between sporadic and syndromic Peutz-Jeghers polyps

Bella Lingjia Liu,

Stephen C. Ward,

Alexandros D. Polydorides

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2024

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Cited by 2 publications

References 34 publications

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Solitary Peutz–Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review

Maeda,

Yoshizawa,

Oyama

et al. 2024

Clin J Gastroenterol

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A solitary Peutz–Jeghers (PJ) polyp is a rare hamartomatous lesion without an associated PJ syndrome. However, little is known regarding malignancy arising in solitary PJ polyps. Here, we report a case of a solitary colonic PJ polyp with focal dysplasia. A 45-year-old asymptomatic man underwent total colonoscopy following a positive fecal occult blood test. The patient had no history of mucocutaneous pigmentation or family history of PJ syndrome. A 20 mm erythematous pedunculated polyp was observed in the sigmoid colon. Magnified endoscopy revealed a tubular or branch-like pit pattern with localized areas of irregular pits. These findings were suggestive of colorectal adenoma with high-grade dysplasia, and endoscopic mucosal resection was performed. Histopathological examination revealed arborizing proliferation of hyperplastic epithelia with smooth muscle bundles. In addition, a small number of irregular crypts with high-grade dysplasia were observed in the hyperplastic epithelium. Based on these histological findings, we finally diagnosed the patient with a solitary colonic PJ polyp with high-grade dysplasia. The present case suggests that solitary colonic PJ polyps may harbor dysplastic changes and require pathological evaluation with en bloc resection of the polyps.

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Solitary Peutz–Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review

Maeda,

Yoshizawa,

Oyama

et al. 2024

Clin J Gastroenterol

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A case report and literature review of Peutz-Jeghers syndrome complicating acute small-bowel intussusception

Ma,

Qiu,

Jia

2024

Asian Journal of Surgery

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Clinicopathologic comparison between sporadic and syndromic Peutz-Jeghers polyps

Cited by 2 publications

References 34 publications

Solitary Peutz–Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review

Solitary Peutz–Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review

A case report and literature review of Peutz-Jeghers syndrome complicating acute small-bowel intussusception

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