Clinicopathologic Correlation of Choroidal Neovascularization Demonstrated by Indocyanine Green Angiography in a Patient With Retention of Good Vision for Almost Four Years

Vascular endothelial growth factor in eye disease

“…It also is clear from fundus imaging and histopathologic studies (Bressler et al, 1988;Chang et al, 1994;Jalkh et al, 1990;Hartnett and Elsner, 1996), that CNV can develop within different planes: in the sub-RPE space and within Bruch's membrane [occult CNV or ill-defined hyperfluorescence on fluorescein angiography ( Fig. 19B)]; or within the neurosensory retina above the RPE termed well-defined CNV based on the fluorescein angiographic appearance (Fig.…”

“…19C) (Hartnett and Elsner, 1996;Bressler et al, 1990;Macular Photocoagulation Study Group, 1996). In occult CNV, vision can remain stable (Bressler et al, 1988;Macular Photocoagulation Study Group, 1996;Chang et al, 1994) or even improve (Jalkh et al, 1990). However, with time, well-defined areas of hyperfluorescence often develop within occult CNV, suggesting a transition from CNV beneath the RPE to that within the neurosensory retina.…”

Surgical induction of choroidal neovascularization in a porcine model

“…Several histopathological studies have been conducted and important information about the pathogenesis of choroidal neovascularization (CNV) has been obtained [3,10,21,22]. However, data about the earliest pathogenesis of this condition remains elusive since histological studies on human CNV are done in the late stage when CNVmembranes have been surgically excised [10,22] or on whole eyes which have been obtained post-mortem [3,21].…”

Overproduction of N.EPSILON.-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Aged Rat

“…25) The AGEs accumulated in soft macular drusen and/or retinal pigment ep- ithelial cells in choroidal neovascular membranes have been suggested to possibly contribute to the development of AMD using human subjects.…”