Clinicopathologic Efficacy of Copper Bromide Plus/Yellow Laser (578 nm with 511 nm) for Treatment of Melasma in Asian Patients

Lee, Hyein; Lim, Yun Young; Kim, Beom Joon; Kim, Myeung Nam; Min, Hye Jung; Hwang, Jung Hee; Song, Kye Yong

doi:10.1111/j.1524-4725.2010.01564.x

Cited by 84 publications

(55 citation statements)

References 25 publications

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“…In a recent pilot study, 10 Korean women with mixed or epidermal melasma were treated with a copper bromide laser emitting both wavelengths simultaneously at 2-week intervals for a total of 8 weeks. 84 MASI scores decreased modestly from an average of 12.3 pretreatment to 9.5 at the 1-month posttreatment follow-up. Using a chromameter, the authors noted measurable lightening of lesional skin after treatment, but the effects appeared to wane slightly at the 1-month posttreatment follow-up.…”

Section: Copper Bromide Lasermentioning

confidence: 85%

Melasma: A comprehensive update

Sheth

Pandya

2011

Journal of the American Academy of Dermatology

265

288

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Several methods of treatment are available to patients with melasma. First-line therapy usually consists of topical compounds that affect the pigment production pathway, broad-spectrum photoprotection, and camouflage. Second-line therapy often consists of the addition of chemical peels, although these must be used cautiously in patients with darker skin. Laser and light therapies represent potentially promising options for patients who are refractory to other modalities, but also carry a significant risk of worsening the disease. A thorough understanding of the risks and benefits of various therapeutic options is crucial in selecting the best treatment.

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Section: Copper Bromide Lasermentioning

confidence: 85%

Melasma: A comprehensive update

Sheth

Pandya

2011

Journal of the American Academy of Dermatology

265

288

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“…The individual pulse cannot supply sufficient thermal energy to coagulate the vessels being treated. The summation of thermal energy from numerous pulses will coagulate the vessels16. Favorable results for the reduction of vascular erythema by 578 nm copper bromide laser have already been reported when treating vascular lesions like telangiectasia, port wine stains, spider nevi, and hemangioma10,17,18,19,20,21,22.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study of the Efficacy of 578 nm Copper Bromide Laser Combined with Intralesional Corticosteroid Injection for Treatment of Keloids and Hypertrophic Scars

et al. 2014

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BackgroundTreatments including intralesional corticosteroid injection, pressure therapy, cryotherapy, and various laser therapies have had limited success for keloids and hypertrophic scars.ObjectiveThis trial evaluated the efficacy of a combination of 578 nm copper bromide laser and the more traditional intralesional corticosteroid injection for the treatment of keloids and hypertrophic scars with respect to scar color.MethodsKeloids or hypertrophic scars of 12 Korean patients were treated five times by the combined treatment at 4-week intervals. Clinical improvement was assessed by the physicians' global assessment (PGA) comparing pre- and post-treatment photographs, as well as 4 weeks after the last treatment. Erythema intensity was quantified using a mexameter.ResultsMost scars showed significant clinical improvement in PGA and decreased erythema intensity after 5 treatments. All patients showed improvements in symptoms like pruritus.ConclusionThe combined treatment is effective for keloids and hypertrophic scars, especially when the telangiectatic portion of the scars is prominent. The adjunctive use of 578 nm copper bromide laser decreased the telangiectatic side effects of an intralesional corticosteroid injection by reducing the vascular components of scars.

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“…The copper bromide laser was consistently reported to have disappointing results in the literature with the exception of a Korean study published in 2010. [80][81][82] In the late 1990s, a study reported that the picosecond laser had superior efficacy than the nanosecond laser in tattoo removal. 83 The picosecond alexandrite laser was developed and shown to be effective in tattoo removal, 84,85 leading to its recent commercialization.…”

Section: New Laser Therapiesmentioning

confidence: 99%

“…[76][77][78][79][80] Although the conventional laser treatment of melasma using QS alexandrite laser and QS ruby laser has brought poor results, lowering the fluence or using the fractional mode is expected to widen the application of these lasers in melasma. The copper bromide laser was consistently reported to have disappointing results in the literature with the exception of a Korean study published in 2010.…”

Section: New Laser Therapiesmentioning

confidence: 99%

Current and New Strategies for Managing Non-Responders to Laser Toning in the Treatment of Melasma

Park

Yeo²

2016

Medical Lasers

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Melasma is one of the most common forms of acquired hyperpigmentation in Asians. It is often intractable with a high rate of recurrence. Several years ago, the collimated low-fluence 1,064 nm Q-switched neodymiumdoped yttrium aluminum garnet laser was introduced as the "laser toning" for the treatment of melasma. Laser toning has been established as an excellent treatment option for melasma with proven efficacy, and it has gained widespread usage. Compared to the early days of laser toning, recent laser toning treatment is associated with lower fluence, fewer passes, wider intervals between treatment sessions, and a minimal and milder tissue response. This recent approach can reduce the risk of mottled hypopigmentation, postinflammatory hyperpigmentation, rebound hyperpigmentation, and recurrence of melasma. However, there are a growing number of non-responders to the recent laser toning technique, which can be problematic for some doctors. Dermatologists should be aware of the various ways to manage non-responders. Moreover, they should also have an accurate understanding of the mechanisms and principles of these modalities to apply optimal treatment methods for each patient condition and melasma state. Further research and updates are necessary to improve the safety and efficacy of laser therapy for melasma.

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Clinicopathologic Efficacy of Copper Bromide Plus/Yellow Laser (578 nm with 511 nm) for Treatment of Melasma in Asian Patients

Abstract: The potential application of an antiangiogenetic laser for the treatment of melasma specially accompanied by pronounced telangiectasia in Asian skin is a possible treatment option.

Cited by 84 publications

References 25 publications

Melasma: A comprehensive update

Melasma: A comprehensive update

Pilot Study of the Efficacy of 578 nm Copper Bromide Laser Combined with Intralesional Corticosteroid Injection for Treatment of Keloids and Hypertrophic Scars

Current and New Strategies for Managing Non-Responders to Laser Toning in the Treatment of Melasma

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