Clinicopathologic evaluation of salivary gland neoplasms: a 38-year retrospective study in Iran

Saghravanian, Nasrollah; Ghazi, Narges; Saba, Mojdeh

doi:10.1016/j.anndiagpath.2013.05.008

Cited by 17 publications

(27 citation statements)

References 27 publications

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“…The type of center in which cases originate may affect this result, given that university centers are more likely to encounter minor salivary glands lesions than major salivary gland lesions, which are generally treated in hospital settings. In the present series, the submandibular gland was the second most frequent localization, followed by minor salivary glands, similar to the report by Saghravanian et al (22), in which 16.25% of cases were minor salivary glands. It should be taken into account that the biopsy results are classified by anatomic site in our hospital and some minor salivary glands may be categorized as of intraoral rather than salivary gland origin, producing a possible underestimation.…”

Section: Discussionsupporting

confidence: 92%

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Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

Collazo-Fernández

Campo‐Trapero²,

Cano‐Sánchez³

et al. 2017

Med Oral

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BackgroundThe clinical and histological characteristics of salivary gland tumors vary widely, complicating their diagnosis and management, and major differences have been recorded in the distribution of histopathological diagnoses among different countries.Material and MethodsThis retrospective study reviewed the demographic (age, sex) and clinicopathological (pathology diagnosis and localization) characteristics of cases diagnosed with primary SGC between June 1992 and May 2014 in the Pathology Department of the 12 de Octubre Hospital of Madrid. Diagnoses were recorded according to the 2005 WHO classification.ResultsThe study included 149 SCG patients, aged between 11 and 94 yrs, with mean age at onset of 55.56 yrs and peak incidence in the eighth decade of life. The male:female ratio was 1.01. The parotid gland was the most frequently involved (75.2%). The most frequent carcinoma was mucoepidermoid carcinoma (24.2%), followed by acinic cell carcinoma (15.4%).ConclusionsThe demographic and histopathological characteristics of patients with salivary gland carcinomas in Spain, reported here for the first time, are broadly similar to those found in other countries. Key words:Salivary gland carcinomas, descriptive, salivary glands, salivary gland tumors, head and neck cancer, oral cancer, Spain.

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Section: Discussionsupporting

confidence: 92%

“…MEC was the most frequent histopathological diagnosis (24.2%), as found by various authors (5,6,11,13,18,19,21,22) followed by AcCC (15.4%) and SCC (11.4%). In some other series, the percentages of MEC and ACC cases were similar (10,15) or ACC was the most frequent (3,7,5,12,14,16,20).…”

Section: Discussionmentioning

confidence: 58%

Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

Collazo-Fernández

Campo‐Trapero²,

Cano‐Sánchez³

et al. 2017

Med Oral

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“…[1][2][3] The molecular events associated with their development and clinicopathologic heterogeneity are poorly elucidated. 21 The HGF/c-MET pathway has been studied in several types of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…1 SGTs can be classified as benign tumors characterized by slow growth and indolent disease progression or malignant tumors that progress rapidly and are associated with low survival rates. [1][2][3][4][5] Patients with SGTs experience significant morbidity and debilitating disfigurement from therapy. Surgery is the main treatment option for malignant SGTs, but the 5-year survival rate for stages II, III, and IV is only 20% to 25%.…”

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confidence: 99%

Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors

Vasconcelos

Wagner

Meurer

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…(1,2) Regardless of their low incidence, they are of concern due to their differences in microscopic patterns and clinical mannerisms . (3)(4)(5)(6) MEC and adenoid cystic carcinoma are the most common salivary gland malignancies. (1) Histopathologic examination of MEC shows that a tumor consist of nests and islands of epidermoid, mucous, and intermediate cells with cystic spaces of various sizes in a fibrous stroma.…”

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confidence: 99%

The Prevalence of Salivary Gland Mucoepidermoid Carcinoma in Iran: An 11 years’ retrospective study

Lotfi

Atarbashi-Moghadam

Karami

et al. 2016

3dj

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Introdouction:Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland malignancies. The prevalence of salivary gland tumors varies in different geographic areas. In this report, we evaluated the prevalence of MEC in Iran and compared it with that previously reported in other countries. Materials and methods:The files of oral pathology, Shahid Beheshti University of Medical Sciences, Amiralam and Taleghani hospitals, served as the source of the material from 2001 to 2011 for this study. Information, including patient's age, gender, tumor location, clinical symptoms and histopathologic grade was recorded. Mann-Whitney test was used for statistical analysis. Results:Mucoepidermoid carcinoma accounted for 24.1% of salivary gland malignancies during the 11-year period. Most cases were diagnosed in the third to fifth decades of life and the male to female ratio was 1:03. The parotid gland was the most common location (49.5%). Tumor grading was available for 92 neoplasms and of them, 39.13% was graded low, 32.6% was intermediate and 28.26% was high grade. Swelling, pain and ulceration existed in 68.6%, 30.4% and 4.8% of patients, respectively. Forty-four point forty-five per cent of cases that demonstrated pain were high grade, 29.6% were intermediate, and 25.9% were low grade (p = 0.03). High grade tumors were more common in males (p = 0.06). Conclusion:The mean age, site of involvement, sex of patient, and microscopic grading of salivary gland MEC in the Iranian population were found to be similar to those of most other countries.Abstract Fifty-eight cases (50.9%) occurred in men and 56 cases (49.1%) in women. The parotid gland was the most common location (49.5%), followed by the palate (12.6%) ( Table 1).

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Clinicopathologic evaluation of salivary gland neoplasms: a 38-year retrospective study in Iran

Cited by 17 publications

References 27 publications

Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors

The Prevalence of Salivary Gland Mucoepidermoid Carcinoma in Iran: An 11 years’ retrospective study

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