Clinicopathologic factors related to surgical margin involvement, reoperation, and residual cancer in primary operable breast cancer – An analysis of 2050 patients

Lai, Hung-Wen; Huang, Ren-Hung; Wu, Yuting; Chen, Chih‐Jung; Chen, Shou‐Tung; Lin, Ying-Jen; Chen, Dar‐Ren; Lee, Chih-Wei; Wu, Hwa-Koon; Lin, Hai; Kuo, Shou‐Jen

doi:10.1016/j.ejso.2018.07.056

Cited by 28 publications

(29 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to our results, the use of breast MRI resulted in statistically significant more frequent cancer-free surgical margins in the case of ILC (79% versus 73%, p = 0.002), but not in the subgroup of invasive carcinoma NST (p = 0.39). In contrast to our results, Lai et al showed an overall increased risk of surgical margin involvement when breast MRI was omitted [18]. This could be explained, among other things, by the inclusion of patients diagnosed with DCIS only in the study of Lai et al in contrast to our cohort including patients diagnosed with invasive breast cancer only.…”

Section: Discussioncontrasting

confidence: 99%

“…This could be explained, among other things, by the inclusion of patients diagnosed with DCIS only in the study of Lai et al in contrast to our cohort including patients diagnosed with invasive breast cancer only. Consequently, the percentages of radical surgical margins differed among the studies (88.7% [18] versus 83.9% in our study). This study has several strengths and limitations.…”

Section: Discussioncontrasting

confidence: 69%

See 1 more Smart Citation

The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study

Nijnatten

Tiel

Voogd

et al. 2020

Breast Cancer Res Treat

View full text Add to dashboard Cite

Purpose To evaluate the effect of breast MRI on overall survival (OS) and disease-free survival (DFS) of patients with invasive breast cancer in the Netherlands. Methods We selected all women from the Netherlands Cancer Registry diagnosed with invasive breast cancer (a) between 2011 and 2013 for the OS-cohort and (b) in the first quarter of 2012 for the DFS-cohort. The study population was subdivided into an MRI and non-MRI group. In addition, subgroups were created according to breast cancer subtype: invasive carcinoma of no special type (NST) versus invasive lobular carcinoma (ILC). OS and DFS were compared between the MRI and non-MRI group using the Kaplan–Meier method and the log-rank test. Cox proportional hazard regression analysis was performed to estimate hazard ratios (HR) with a 95% confidence interval (CI). To account for missing data, multiple imputation was performed. Results Of the 31,756 patients included in the OS-cohort (70% non-MRI and 30% MRI), 27,752 (87%) were diagnosed with invasive carcinoma NST and 4004 (13%) with ILC. Of the 2464 patients included in the DFS-cohort (72% non-MRI and 28% MRI), 2161 (88%) were diagnosed with invasive carcinoma NST and 303 (12%) with ILC. The distribution of breast MRI use was significantly lower over different age categories, from 49.0% aged < 50 to 16.5% aged > 70. Multivariable Cox regression showed that breast MRI was not significantly associated with OS overall (HR 0.91, 95%-CI 0.74–1.11, p = 0.35), nor in the different histological subtypes. Multivariable Cox regression analysis showed that breast MRI was also not significantly associated with DFS (HR 1.16, 95%-CI 0.81–1.67), nor in the different histological subtypes. Conclusion Use of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 69%

The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study

Nijnatten

Tiel

Voogd

et al. 2020

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

Section: Selection Of Gas5 Genetic Polymorphismssupporting

confidence: 73%

“…Two GAS5 genetic variants rs145204276 and rs55829688 were detected in compliance with the data of International HapMap Project and previous study [28]. The polymorphism rs145204276 AGGCA/-was demonstrated to be located at the promoter region of lncRNA GAS5 and was associated with the progression of several cancers [28,29]. GAS5 genetic polymorphisms rs145204276 and rs55829688 were examined by ABI StepOne Real-Time PCR System (Applied Biosystems, Foster City, CA, USA) as well as delineated with SDS vers.…”

Section: Selection Of Gas5 Genetic Polymorphismsmentioning

confidence: 76%

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer

Weng

Lee

et al. 2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

The purposes of the investigation were to examine the implications of long noncoding RNA growth arrest-specific transcript 5 (GAS5) in progression and clinicopathological factors of uterine cervical cancer, and patient survival in Taiwan. Genotypic distributions of two GAS5 genetic variants rs145204276 and rs55829688 were detected in 208 patients including 111 patients with invasive cancer, 97 with precancerous lesions as well as 307 control women using real-time polymerase chain reaction. It explored that patients with cervical precancerous lesion had lower rate of AGGCA deletion (Del) in both alleles (Del/Del) of GAS5 rs145204276 as compared with control women. Patients with invasive cancer did not exhibit higher rate of Del/Del. Meanwhile, there were no different genotypic distributions in rs55829688 among patients with cervical invasive cancer and those with precancerous lesions as well as control women. Moreover, cervical cancer patients with Ins (insertion, AGGCA)/Del and Del/Del (-/-) in GAS5 rs55829688 tended to have poorer hazard ratio (HR) of 5 years survival. In addition, lymph node metastasis status exerted the most significantly predictive of 5 years survival rate. Conclusively, GAS5 polymorphism rs145204276 is probably applicable to predict 5 years survival HR of cervical cancer patients. However, the mechanism elucidating the methylation status and transcription function of rs145204276 in uterine cervical cancer needs to be delineated for its unique implication in uterine cervical cancer.

show abstract

“…An increasing number of patients choose breast-conserving surgery, which could lead to more positive incision margins during the operation. [8][9][10] Therefore, the positive incision margin during operation has attracted increased attention.…”

Section: Introductionmentioning

confidence: 99%

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

Zhu

Liu

Feng

et al. 2020

Tissue Engineering Part A

View full text Add to dashboard Cite

The positive surgical margins in solid tumors has been a disturbing issue for clinicians. Chemotherapy is an important method to deal with the positive margin. However, systemic chemotherapy is required for long-term administration and has great side effects on health, which cause great pain to the patients. Local administration of slow-release materials provides an opportunity to improve the situation. In this study, we utilized electrospinning technology to create the drug sustained-release materials with nanofibrous structure, which were made from polylactic acid and a certain proportion of chemotherapy drugs (gemcitabine and cisplatin). In vitro release behavior of the drug sustained-release materials were explored by the high-performance liquid chromatography. The antitumor efficacy of the drug sustained-release materials was preliminarily verified in prostate cancer and breast cancer in vitro. Through animal models of breast cancer, the drug sustained-release materials in the treatment of the positive margin has been well documented in vivo, and we also found that the drug sustained-release materials could definitely reduce the liver damage and myelosuppression compared with systemic chemotherapy. In summary, the experimental results showed that the local administration of the drug sustained-release materials could effectively inhibit the growth of the positive incision margins and definitely reduce the partial side effects associated with systemic chemotherapy.

show abstract

Clinicopathologic factors related to surgical margin involvement, reoperation, and residual cancer in primary operable breast cancer – An analysis of 2050 patients

Cited by 28 publications

References 49 publications

The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study

The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

Contact Info

Product

Resources

About