Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma

Prieto-Granada, Carlos; Xu, Bin; Alzumaili, Bayan; Rasheed, Mohamed Rizwan Haroon Al; Eskander, Antoine; Enepekides, Danny; Patel, Snehal G.; Stevens, Todd M.; Doğan, Snjezana; Ghossein, Ronald; Katabi, Nora

doi:10.1007/s00428-021-03117-2

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…Two of them were spindle‐cell SCC: rare, aggressive, and poorly differentiated variants of SCC which are often diagnostic challenges for pathologists. Studies showed that this type of tumor could often mimic benign mesenchymal proliferation 32,33 . We hypothesize that these histopathologic features may influence fluorescence findings as well.…”

Section: Discussionmentioning

confidence: 85%

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Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

Gaiffe,

Mahdjoub,

Ramasso

et al. 2024

Head & Neck

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BackgroundAutofluorescence spectroscopy is effective for noninvasive detection but underutilized in tissue with various pathology analyses. This study evaluates whether AFS can be used to discriminate between different types of laryngeal lesions in view of assisting in vocal fold surgery and preoperative investigations.MethodsA total of 1308 spectra were recorded from 29 vocal fold samples obtained from 23 patients. Multiclass analysis was performed on the spectral data, categorizing lesions into normal, benign, dysplastic, or carcinoma.ResultsThrough an appropriate selection of spectral components and a cascading classification approach based on artificial neural networks, a classification rate of 97% was achieved for each lesion class, compared to 52% using autofluorescence intensity.ConclusionsThe ex vivo study demonstrates the effectiveness of AFS combined with multivariate analysis for accurate classification of vocal fold lesions. Comprehensive analysis of spectral data significantly improves classification accuracy, such as distinguishing malignant from precancerous or benign lesions.

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Section: Discussionmentioning

confidence: 85%

“…Studies showed that this type of tumor could often mimic benign mesenchymal proliferation. 32,33 We hypothesize that these histopathologic features may influence fluorescence findings as well. The third case was a micro-invasive SCC with underlying inflammatory stroma, which may account for our results.…”

Section: Discussionmentioning

confidence: 99%

Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

Gaiffe,

Mahdjoub,

Ramasso

et al. 2024

Head & Neck

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“…4 Pan-CK positivity in absence of myogenic markers may lead to misdiagnosis of epithelial tumors or carcinomas most likely spindle cell carcinoma. 22 This keratin immunoexpression may be attributed to the presence of EWSR1 involvement. Therefore, it is mandatory to have a panel of IHC markers, myogenic as well as epithelial markers in diagnosis of primitive and undifferentiated IRMS cases.…”

Section: Discussionmentioning

confidence: 97%

Clinicopathological and Molecular Characteristics of Intraosseous Rhabdomyosarcoma Involving Head and Neck Region: A Systematic Review and Meta-Analysis

et al. 2023

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Rhabdomyosarcoma with TFCP2 rearrangement is a newly introduced spindle cell neoplasm showing predilection for craniofacial bones exhibiting highly aggressive nature and poor prognosis. Therefore, an attempt was made to delineate the entity for improved understanding and treatment outcomes through comprehensive analysis of the clinicopathological and molecular characteristics. An electronic search was carried out using MEDLINE by PubMed, Scopus, Google scholar, Cochrane library, and EMBASE databases. Original articles and case reports involving intraosseous rhabdomyosarcoma arising in head and neck region with TFCP2 fusion were included. Data were compiled and risk of bias was analyzed using JBI tool. Thirteen eligible articles were included for the quantitative analysis, which revealed 33 cases with TFCP2 fusion. Majority of the affected individuals were females (58%) with mandible being the common site. Most of the patients died within few months after diagnosis demonstrating a low mean survival rate (30 months). Odds ratio, overall survival and disease-free survival were calculated and analyzed statistically concluding that intraosseous rhabdomyosarcomas harboring TFCP2 fusion are found to be novel and dreadful neoplasms. The predilection for young age with poor prognosis exhibited by these lesions demand early diagnosis and specific treatment planning to curtail mortality.

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“…Sarcomatoid squamous cell carcinoma (SSCC), also known as spindle cell squamous cell carcinoma, is a rare and peculiar biphasic malignant neoplasm that occurs mainly in the larynx, but also in other mucosal areas such as the gingiva, tongue, pharynx, and nasal cavity, accounting for 0.4%–4% of HNSCC ( 4 ). GSCC accounts for less than 1% of all tumors in the oral region, and GSSCC is even rarer.…”

Section: Discussionmentioning

confidence: 99%

Case report: Prompt response to radiotherapy and chemotherapy combined with crizotinib in gingival sarcomatoid squamous cell carcinoma with MET 14 mutation

Sun

Xia²,

Zhang³

et al. 2022

Front. Oncol.

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BackgroundAs a kind of squamous cell carcinoma of head and neck (HNSCC), gingival sarcomatoid squamous cell carcinoma (GSSCC) is a rare biphasic malignant neoplasm. To date, surgical resection was often utilized for gingival squamous cell carcinoma (GSCC), while for patients with advanced gingival carcinoma who cannot tolerate surgery, radiotherapy and chemotherapy can be regarded as a treatment strategy. Many molecular-targeted drugs were investigated and approved for the treatment of malignant diseases, including hematologic diseases and solid tumors. Although targeted therapies such as EGFR inhibitors have shown therapeutic efficacy in HNSCC, there are still some patients who cannot benefit from it. New therapeutic targets and strategies should be further explored.Case presentationAn 83-year-old woman was referred to our hospital with left lower gingival mass for more than 1 month in June 2021. Pathologic diagnosis is sarcomatoid squamous cell carcinoma. Due to the large tumor at the time of diagnosis and poor quality of life, the patient was intolerant to surgery, so she was given radiotherapy (RT) combined with concurrent chemotherapy (CT) with albumin bound paclitaxel. According to next-generation sequencing (NGS) results (MET exon 14 skipping mutation-positive), she was treated with crizotinib, a tyrosine kinase inhibitor that targets MET. Through the comprehensive treatment, the patient’s condition promptly improved, clinical complete remission (CR) was achieved in 2 months, and 9-month progression-free survival (PFS) was obtained. She finally died from non-cancer-related diseases.ConclusionHere we report the treatment of a GSSCC patient with MET mutation, who responded to crizotinib promptly and positively. It provides a new reference for understanding MET abnormalities in GSSCC and offers a new idea for the targeted treatment of gingival carcinoma.

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Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma

Cited by 14 publications

References 28 publications

Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

Clinicopathological and Molecular Characteristics of Intraosseous Rhabdomyosarcoma Involving Head and Neck Region: A Systematic Review and Meta-Analysis

Case report: Prompt response to radiotherapy and chemotherapy combined with crizotinib in gingival sarcomatoid squamous cell carcinoma with MET 14 mutation

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