Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Abstract

In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20.0.Twenty women were histopathologically diagnosed as having vaginal adenosis (mean age, 37.9 ± 10.6 years). All patients denied utero exposure. The most common symptom was vaginal pain or abnormal bleeding. For all patients, the local vaginal lesions were surgically excised. Seven patients had complications with endometriosis. 15 patients lived without recurrence, and 1 patient underwent postoperative local recurrence after 81 months. Primary vaginal squamous cell carcinoma in another patient was confirmed to arise from adenosis; she survived with disease. The remaining 3 patients developed carcinoma of different types in varied periods of a disease-free state (5 months, 30 months, and 23 years, respectively); 1 patient died of progressive disease, and 2 patients survived with disease.Primary vaginal adenosis is a spontaneous lesion with a propensity for late canceration. Local lesion resection is the primary treatment.

Menstural function preservation treatment of a primary vaginal clear cell carcinoma with ovarian transposition and vaginal brachytherapy

“…( Van Gorp et al, 2004 ) Moreover, an association between endometriosis and VA has also been reported. ( Han et al, 2018 )…”

A case of vaginal adenosis with gastric differentiation

“…All 20 patients underwent local excision of their lesions. Four patients went on to develop malignancy (one squamous cell, one mucinous, and two clear cell carcinomas) ( Han, 2018 ). These findings would seem to confirm that while the incidence is very rare its malignant potential is still quite high.…”

Malignant transformation of vaginal adenosis to clear cell carcinoma without prenatal diethylstilbestrol exposure: a case report and literature review

“…Most patients with vaginal adenosis have no obvious symptoms. The lesions range widely, and symptoms can manifest as postcoital hemorrhage, sexual pain and a vaginal burning sensation [20]. In some cases, vaginal palpation reveals submucous nodular or sandy lesions 0.5–5 cm in diameter [20].…”

“…The lesions range widely, and symptoms can manifest as postcoital hemorrhage, sexual pain and a vaginal burning sensation [20]. In some cases, vaginal palpation reveals submucous nodular or sandy lesions 0.5–5 cm in diameter [20]. However, the main clinical manifestations of vaginal cancer include irregular vaginal bleeding, postpartum hemorrhage, postmenopausal hemorrhage and increased leucorrhea.…”