Clinicopathologic features and survival outcomes of primary signet ring cell carcinoma of colon: Retrospective analysis of VACCR database.

Thota, Raja; Birdsong, Sara; Tashi, Tsewang; Gonsalves, Wilson I.; Tiwana, Jasleen; Sama, Ashwin R.; Krishnamurthy, Jairam; Fang, Xing; Townley, P.; Silberstein, Peter T.; Subbiah, Suki

doi:10.1200/jco.2011.29.15_suppl.e14097

Cited by 23 publications

(43 citation statements)

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“…With regard to gender, similar incidence rates for SRCC were found among males and females [9,11], however SRCC of the rectum was more frequently diagnosed in men [13]. SRCC are largely located within the right colon [12,13], and rectum location represents about 20% [13]. SRCC are usually diagnosed at advanced stages as opposed to non-SRCC of the colon and the rectum [3,12].…”

Section: Epidemiologic Featuresmentioning

confidence: 73%

“…Incidence rates for colonic and rectal SRCC differ by race/ethnicity. Lower percentages were found in African Americans and Hispanic populations than in Caucasians [11,12]. With regard to gender, similar incidence rates for SRCC were found among males and females [9,11], however SRCC of the rectum was more frequently diagnosed in men [13].…”

Section: Epidemiologic Featuresmentioning

confidence: 74%

“…The reported frequency varies from 0.3 to 4.6% of all colorectal carcinomas with slight differences between western countries, Asia and Africa (figure 1) [3,[5][6][7][8][9][10][11][12]. The highest incidence of SRCC of the colon and rectum is reported in countries with low overall prevalence of colorectal cancer, such as Tanzania [10].…”

Section: Epidemiologic Featuresmentioning

confidence: 98%

“…The highest incidence of SRCC of the colon and rectum is reported in countries with low overall prevalence of colorectal cancer, such as Tanzania [10]. However, these data should be interpreted carefully because the majority of epidemiological data on SRCC of the colon and rectum are based on single institution studies [5,6,10], rarely from large population-based studies of colorectal cancer histology [11,12]. The mean age at diagnosis of colorectal SRCC reported in published series ranges from 48 to 70 years old [7,9].…”

Section: Epidemiologic Featuresmentioning

confidence: 99%

“…SRCC are largely located within the right colon [12,13], and rectum location represents about 20% [13]. SRCC are usually diagnosed at advanced stages as opposed to non-SRCC of the colon and the rectum [3,12]. A large cohort from US found that 80% of colorectal SRCC were diagnosed at stage III and IV versus 50% in non-SRCC (P < 0.01) [13].…”

Section: Epidemiologic Featuresmentioning

confidence: 99%

See 4 more Smart Citations

Primary signet ring cell carcinoma of the colon and rectum

Arifi

Elmesbahi

Riffi³

2015

Bulletin du Cancer

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Section: Epidemiologic Featuresmentioning

confidence: 73%

Section: Epidemiologic Featuresmentioning

confidence: 74%

Section: Epidemiologic Featuresmentioning

confidence: 98%

Section: Epidemiologic Featuresmentioning

confidence: 99%

Section: Epidemiologic Featuresmentioning

confidence: 99%

See 3 more Smart Citations

Primary signet ring cell carcinoma of the colon and rectum

Arifi

Elmesbahi

Riffi³

2015

Bulletin du Cancer

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Comparison of 627 patients with right‐ and left‐sided colon cancer in China: Differences in clinicopathology, recurrence, and survival

Qin

Yang

Sun

et al. 2017

Chronic Diseases and Translational Medicine

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ObjectiveRecent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS).MethodsWe identified patients from 2005 to 2008 with stage II/III colon cancer who underwent surgery for curative intent. We explored the impact of the tumor location on the postoperative DFS and OS using univariate and multivariate analyses.ResultsOf 627 patients, 50.6% (317/627) had right-sided colon cancer. These patients were more likely to have weight loss, second primary tumor, elevated preoperative carbohydrate antigen 19-9 (CA19-9), increased incidence of non-adenocarcinoma, more poorly differentiated tumors, vascular invasion, defective mismatch repair, and a lighter smoking history (P < 0.05). Right-sided colon cancer had a higher recurrence incidence compared with left-sided cancer (30.6% vs. 23.2%, P = 0.037), particularly with multiple metastatic sites in the first recurrence (17.5% vs. 5.6%, P = 0.020). Kaplan–Meier survival curves demonstrated a significant difference in the 5-year DFS rate between right- and left-sided cancers across all stages (68.1% vs. 75.2%, P = 0.043). However, there was no significant difference in the 5-year OS rate between the two groups (73.8% vs. 79.0%, P = 0.103). Subgroup analysis demonstrated that patients with left-sided colon cancer had a significantly better 5-year DFS and OS rates compared with those with right-sided disease at stage III (64.3% vs. 46.8%, P = 0.002; 69.5% vs. 53.5%, P = 0.006, respectively); there were no significant differences in the 5-year DFS and OS rates at stage II (85.2% vs. 85.9%, P = 0.819; 89.8% vs. 88.5%, P = 0.803, respectively). Adjusted Cox regression analysis showed no significant differences in the 5-year OS and DFS rates for stage II [hazard ratio (HR) = 1.203, 95% confidence interval (CI): 0.605–2.391, P = 0.598; HR = 0.980, 95% CI: 0.542–1.774, P = 0.948, respectively] or all stages combined (HR = 0.867, 95% CI: 0.613–1.227, P = 0.421; HR = 0.832, 95% CI: 0.606–1.142, P = 0.255, respectively). However, stage III left-sided cancer had higher 5-year OS and DFS rates (HR = 0.626, 95% CI: 0.414–0.948, P = 0.027; HR = 0.630, 95% CI: 0.428–0.926, P = 0.019, respectively).ConclusionWe found that right- and left-sided colon cancers had significantly different clinicopathological characteristics. Right-sided colon cancer had a higher incidence of recurrence than left-sided disease. Patients with stage III right-sided colon cancer had a worse prognosis compared with those with stage III left-sided colon cancer.

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Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study

Yang

Wang

2020

Sci Rep

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We aimed to reveal clinicopathological features and explore survival-related factors of colorectal signet ring cell carcinoma (SRCC). A population-based study was carried out to investigate colorectal SRCC by using data extracted from the surveillance, epidemiology and end results (SEER) database between 2004 and 2015. In total, 3,278 patients with colorectal SRCC were identified, with a median age of 63 (12–103) years old. The lesions of most patients (60.49%) were located in the cecum–transverse colon. In addition, 81.27% patients had advanced clinical stage (stage III/IV), and 76.69% patients had high pathological grade. The 3–, 5–year cancer‐specific survival and overall survival rate was 35.76%, 29.32% and 32.32%, 25.14%. Multivariate analysis revealed that primary site in cecum–transverse colon, married, received surgery, lymph node dissections ≥ 4 regional lymph nodes were independent favorable prognostic. Meanwhile, aged ≥ 65 years, higher grade, tumor size ˃5 cm and advanced AJCC stage were associated with poor prognosis. Patient age, tumor grade, marital status, tumor size, primary tumor location, AJCC stage, surgery and number of dissected lymph node had significant correlation with prognosis of colorectal SRCC.

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Clinicopathologic features and survival outcomes of primary signet ring cell carcinoma of colon: Retrospective analysis of VACCR database.

Cited by 23 publications

References 0 publications

Primary signet ring cell carcinoma of the colon and rectum

Primary signet ring cell carcinoma of the colon and rectum

Comparison of 627 patients with right‐ and left‐sided colon cancer in China: Differences in clinicopathology, recurrence, and survival

Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study

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