Clinicopathologic features of biopsied lacrimal gland masses in 95 Korean patients

Ahn, Chanjoo; Kang, Seok Jin; Sa, Ho-Seok

doi:10.1007/s00417-019-04327-w

Cited by 17 publications

(15 citation statements)

References 28 publications

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“… 11 Further, a systemic association was found in 12% of our cases, the most common specific etiology being IgG4 disease, like the Korean and Australian studies. 9 , 11 …”

Section: Discussionmentioning

confidence: 99%

“… 2 Contrarily, the incidence of bilateral disease in patients with lymphoproliferative diseases (67.0%) was higher than that in the non-specific inflammation group (33.0%), unlike previous studies that reported a higher incidence of bilateral disease in chronic dacryoadenitis. 9 , 12…”

Section: Discussionmentioning

confidence: 99%

“… 6–8 Several studies described the histopathological distribution of lacrimal gland lesions worldwide. 1–5 , 9–11 This is the first study in the Saudi population that reviewed the clinical, demographics, radiological, histopathological, and surgical approaches in patients with biopsied lacrimal gland lesions.…”

Section: Introductionmentioning

confidence: 99%

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Lacrimal Gland Lesions Biopsied in a Tertiary Eye Center in Saudi Arabia: A Clinical, Radiological, Surgical, and Histological Review

Alturkistany¹,

Althaqib²,

Alsulaiman³

et al. 2022

OPTH

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Purpose To study the demographics and clinical presentation of biopsied lacrimal gland lesions in a tertiary eye center and determine the accuracy of radiological imaging and blood investigations in reaching the diagnosis. We also studied the histopathological outcome of different lacrimal gland biopsy approaches. Materials and Methods A retrospective review of patients’ charts from 2014 to 2021 who underwent lacrimal gland biopsy. The data collected included demographics, clinical presentations, surgical approaches used, blood workup done, and histopathological and radiological diagnoses. The accuracy of radiological imaging in diagnosing lacrimal gland pathologies was evaluated by comparing radiological interpretation to the final pathological report. Results In a total of 48 cases, the most common lacrimal gland lesion was nonspecific inflammation of the lacrimal gland (34%, n=17) followed by lymphoproliferative lesions (25%, n=12). Females (62.5%, n=30) were more affected than males (37.5%, n=18). Other lesions included pleomorphic adenoma, angiolymphoid hyperplasia with eosinophilia, and IgG4 disease. Complete blood investigations were performed in 45.8% of patients and a systemic disease was found in only 18.2%. The initial assumptive diagnosis based on MRI and CT scan images was congruous with the histopathological diagnosis in 42% and 12%, respectively. Three surgical approaches were used for incisional biopsy in this study, including sub-periosteal, trans-septal, and palpebral lobe biopsy. Lateral orbitotomy was done in all excisional biopsy cases. We found no statistical difference in the histopathological outcome between the different surgical approaches used. Conclusion Nonspecific inflammation and lymphoproliferative disorders are the most common causes of lacrimal gland lesions. Blood work-up should not be used to waive off the need for lacrimal gland biopsy, and the diagnosis should preferably be based on histopathology results. The MRI is a useful tool to diagnose lacrimal gland lesions; however, histopathology remains the gold standard method.

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“… 11 Further, a systemic association was found in 12% of our cases, the most common specific etiology being IgG4 disease, like the Korean and Australian studies. 9 , 11 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lacrimal Gland Lesions Biopsied in a Tertiary Eye Center in Saudi Arabia: A Clinical, Radiological, Surgical, and Histological Review

Alturkistany¹,

Althaqib²,

Alsulaiman³

et al. 2022

OPTH

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“…According to these three criteria, IgG4-related dacryoadenitis was divided into definitive, probable and possible when patient fulfilled all three criteria, the first two criteria and the first and last criteria, respectively. 10…”

Section: Methodsmentioning

confidence: 99%

Clinical, Radiological and Histopathological Features of Patients With Lacrimal Gland Enlargement

et al. 2021

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Background: The purpose of this study was to describe the radiologic and histopathologic features of lacrimal gland in patients presenting with lacrimal gland enlargement. Methods: We retrospectively retrieved the data of patients with lacrimal gland enlargement in Farabi Eye Hospital between 2012 and 2017. These data included demographics, the patients’ facial photographs, orbital CT-scans, and histopathological findings of lacrimal gland biopsies. Results: Forty-seven patients (15 men and 32 women) were enrolled in this study with a median age of 37.9 years (range, 15–79 years). Histopathologic diagnoses were chronic dacryoadenitis in 26 cases (55.32%), IgG4-related disease in 6 patients (12.77%), two cases of acute dacryoadenitis, two cases of non-necrotizing granulomatous inflammation, two cases of Non-Hodgkin’s B-cell lymphoma, two cases of adenoid cystic carcinoma and two cases of mixed tumor (4.26% each), as well as one case of conjunctival epithelial cyst, and one case of benign lymphoid tissue and fibrofatty tissue (2.13%). In two samples (4.26%), biopsy revealed normal lacrimal glands. Interestingly, in two cases with relapsing lacrimal gland enlargement, different histopathologic diagnoses were found in biopsies taken from each lacrimal gland at different times. The average size of enlarged lacrimal glands was 19.67 mm × 7.06 mm on axial CT scan and 19.44 mm × 6.20 mm on coronal CT scan. Conclusion: Tissue biopsy is needed for diagnosis of lacrimal gland enlargement because it is difficult to distinguish the type of the lacrimal gland pathology based solely on clinical or radiological presentation.

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“…Тем не менее своевременное начало лечения ведет к более быстрой и полной ремиссии. В качестве препаратов первой линии для индукции ремиссии предлагаются глюкокортикостероиды (ГКС) либо их комбинация базовыми противовоспалительными препаратами (БПВП) [30,32,33].…”

Section: терапия Igg4-аз сегодня и в перспективеunclassified

IGG4-related diseases in endocrinology

Rumyantsev¹,

Kozlov²,

Kolpakova³

et al. 2020

Probl Endokrinol (Mosk)

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Immunoglobulin-G4-related disease (IgG4-RD) is a chronic immunomediated pathology of different organs of local or systemic nature, which has been established as a separate clinical entity in the early 2000s and is characterized by storiform fibroid inflammation of the affected tissues, their increase, and elevated serum immunoglobulin-G4 (IgG4) levels. The most common manifestations of the disease are major salivary and lacrimal gland enlargement, lymphadenopathy and type 1 autoimmune pancreatitis (AIP1), however, other organs may be also involved (the thyroid, eyes, meninges, heart, lungs, kidneys, aorta, upper airways, mesentery, etc.). The effectiveness of treatment of IgG4-RD, as well as other pathological conditions, is also determined by the timely diagnosis. However, the latter is complicated due to the variety of clinical manifestations and rather variable diagnostic criteria. It is necessary to constantly update the evidence-based knowledge and diagnostic algorithms within this pathology in order to overcome the difficulties, and involve immunologists, endocrinologists, pathologists and specialists in other spheres. This review provides information about the etiology, pathogenesis, and current methods of diagnosis and treatment of IgG4-related diseases, as well as examples of some manifestations of IgG4-RD that an endocrinologist may face in practice.

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Clinicopathologic features of biopsied lacrimal gland masses in 95 Korean patients

Cited by 17 publications

References 28 publications

Lacrimal Gland Lesions Biopsied in a Tertiary Eye Center in Saudi Arabia: A Clinical, Radiological, Surgical, and Histological Review

Lacrimal Gland Lesions Biopsied in a Tertiary Eye Center in Saudi Arabia: A Clinical, Radiological, Surgical, and Histological Review

Clinical, Radiological and Histopathological Features of Patients With Lacrimal Gland Enlargement

IGG4-related diseases in endocrinology

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