Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine

Abstract

Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use.

Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn’s disease

“…This disorder has been previously referred to as “chronic nonspecific multiple ulcers of the small intestine” because of the lack of specific histological findings such as granuloma and eosinophilic infiltration [1, 6]. Furthermore, the rarity of the disease and the term “nonspecific” in its nomenclature has elicited misunderstanding in the interpretation of the disease as various other conditions with multiple small intestinal ulcers of obscure origin [4]. Because CEAS is genetically distinct from other GI disorders, precise recognition of its clinical features and GI pathologies appears mandatory for a correct diagnosis.…”

“…Distinction between ileal CD and CEAS seems indispensable, as neither anti-tumor necrosis factor-α antibody therapy nor immunomodulators are effective against CEAS. Small intestinal ulcers of CEAS have been typically described as circular or obliquely shaped shallow ulcers with clear margins which occur asymmetrically, regardless of mesenteric or anti-mesenteric side [3, 4, 12]. In contrast, small intestinal ulcers in CD are typically longitudinal and commonly found on the mesenteric side [20].…”

“…Recently, it has become evident that the disease is caused by loss-of-function mutations in the SLCO2A1 gene, which encodes a prostaglandin transporter [2]. CEAS is a rare, intractable disease characterized by multiple small intestinal ulcers of nonspecific histology and chronic persistent gastrointestinal (GI) bleeding [3, 4]. Its symptoms, including general fatigue, edema, and abdominal pain, typically appear during adolescence and the clinical course is chronic and intractable.…”

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

“…Cryptogenic multifocal ulcerous stenosing enteritis is a rare idiopathic cause of ulceration and stricture of small bowel, which can be presented with acute or chronic GI bleeding, symptoms of bowel obstruction, abdominal pain, anemia, hypoalbuminemia, and perforation (1)(2)(3)(4)(5).…”

Retrieval of retained capsule endoscopy by device‐assisted enteroscopy in patients with cryptogenic multifocal ulcerous stenosing enteritis

“…2 Thus, patients mostly experience fatigue, edema, anemia and retarded growth. 5,6 A diagnosis of CMUSE should be based on patient's medical history, clinical manifestations, imaging features, endoscopic findings and histopathology. CMUSE can easily be misdiagnosed as CD.…”