Clinicopathologic features of gastric glomus tumor: A report of 15 cases and literature review

Deng, Minying; Luo, Rongkui; Huang, Jie; Luo, Yu; Song, Qing; Liang, Huaiyu; Chen, Xu; Wang, Yuan; Hou, Yayi

doi:10.3389/pore.2022.1610824

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Glomus tumors were first described in 1924 by Masson et al Four years later, Tliejeva et al performed the description of a glomus tumor at the gastric level [ 7 ]. The prevalence of these subepithelial lesions is rarely reported, with studies to date reporting rates between 0.8% and 1.7% [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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A 65-Year-Old Man Presenting to the Emergency Department with Gastric Hemorrhage Caused by a Glomus Tumor

Deacu,

Bosoteanu,

Orășanu

et al. 2023

Am J Case Rep

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Patient: Male, 65-year-old Final Diagnosis: Gastric glomus tumor Symptoms: Gastric hemorrhage Clinical Procedure: — Specialty: Pathology Objective: Rare disease Background: Glomus tumor is a benign but rapidly growing mesenchymal tumor that is a rare in the gastrointestinal tract, can be locally invasive due to its rapid growth, and can result in perforation of a viscus. We report a 65-year-old man presenting as an emergency with gastric hemorrhage and gastric glomus tumor. Case Report: A 65-year-old man came to our hospital for a life-threatening upper digestive hemorrhage. The preoperative examinations (digestive endoscopy without sampling of biopsy fragments and contrast-enhanced computer tomography) led to the presumptive diagnosis of gastrointestinal stromal tumor. Wedge resection of the gastric wall was performed. The histopathological examinations revealed a proliferation of round-oval cells of medium size with a solid disposition and in nests. This proliferation dissected the muscular tunic and caused ulceration of the gastric mucosa. Immunohistochemical tests confirmed the diagnosis of glomus tumor and excluded other diagnoses (neuroendocrine tumor or gastrointestinal stromal tumor). The postoperative evolution was favorable, and at the time of discharge, the biochemical test values normalized. Conclusions: Pathologists are faced with a challenging task due to the deceptive appearance that can be presented by such a rare tumor. Histopathological and immunohistochemical examinations are essential in achieving a precise diagnosis and assessing the biological potential of the glomus tumor. Even if it is a benign tumor, the clinical picture it causes can still be a major risk to the patient’s life. Consequently, ensuring effective case management becomes crucial, as it requires a thorough comprehension of all conditions encompassed in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Macroscopically, the lesions have an average size between 2 and 3 cm and are solitary with well-defined edges. On the section, they have a grayish-reddish color, are of slightly increased consistency, and can be associated with hemorrhage or calcification [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A 65-Year-Old Man Presenting to the Emergency Department with Gastric Hemorrhage Caused by a Glomus Tumor

Deacu,

Bosoteanu,

Orășanu

et al. 2023

Am J Case Rep

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“…Также могут локализоваться на плече [8], бедре [9], в области колена [7,10,11] и локтя [12]. Единичные наблюдения описаны в носовой полости и параназальных пазухах [13], в веке [14] и радужной оболочке глаза [15], в желудочно-кишечном тракте, включая желудок [16,17] и печень [18], в почке [19], надпочечнике [20] и забрюшинном пространстве [21], в легких [22,23] и трахее [24], сердце [25] и молочной желе зе [26,27]. Крайне редкими локализациями опухоли являются яичко [28] и турецкое седло [29].…”

Section: Introductionunclassified

“…Наиболее крупные исследования гломусной опухоли различной локализации[35,39,[51][52][53][55][56][57][58][59][60][61][62][63][64][65][66] …”

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Glomus angioma: series of cases and literature review

Stepanova,

Glotov,

Shirokov

et al. 2023

Medicinskaâ vizualizaciâ

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Glomus tumors usually occur in areas rich in glomus bodies, such as the subungual areas of the fingers or the deep dermis of the palm, wrist, and forearm, but they can also occur in deep visceral sites throughout the body, including the lungs, stomach, pancreas, liver, gastrointestinal and urinary tracts. They are thought to have originated from modified smooth muscle cells of the neuromyoarterial glomus, commonly referred to as the glomus body, whose function is to regulate temperature through arteriovenous shunting of the blood. Important during the pathological process for these tumors are pain that persists for a long time, which is often necessary for their detection and the possibility of relapse.The purpose: to analyze and evaluate our own clinical cases of glomus angioma of various localization.Materials and methods. 6 patients with a morphologically verified diagnosis of glomus angioma (5 women and 1 man aged 23 to 50 years, mean age 34.5 years) were treated at A.V. Vishnevsky National Medical Research Center of Surgery for the period from 2004 to 2023. All patients were operated on. Lesions localization: limbs soft tissues – 3, retroperitoneal space – 2, lung – 1.Results. The term of the lesions detection varied from 2 months to congenital. In 2 of 3 cases of the limbs soft tissues tumors localization they were congenital. Limbs soft tissues glomus tumors: the leions ranged in size from 40.0 × 28.65 mm to a large lesion, consisting of multiple foci ranging in size from 20.0 to 60.0 mm in diameter, all tumors were multinodular. Retroperitoneal glomus tumors: the lesions were rather large (a multinodular lesion from 6.0 to 48.0 mm in diameter and a single-nodular multi-chamber lesion of a polycyclic form, 150.0 × 100.0 × 80.0 mm in size). The lung glomus tumor was single-nodular and had a diameter of 12.5 mm. In the vast majority of cases (5/6), the lesions manifested with the pain and discomfort. Only the lung lesion was detected by chance and during a routine examination.The criteria for ultrasound and MSCT signs of the lesions of various localizations are given. The data are compared with literature data.Conclusion. Given the rarity of glomus angioma and the lack of publications on glomus angiomas of soft tissues of the extremities and deep-seated tumors in the domestic literature, the presented analysis of a series of our own cases will increase the awareness of clinicians and diagnosticians about these tumors and, thereby, increase their detection, which will allow for earlier surgery.

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