Clinicopathologic features of hepatic neoplasms in explanted livers: a single institution experience

Mourad, Walid A.; Khalaf, Hatem; Tulbah, Asma; Omari, Mohammed; Mana, Hadeel Al; Neimatallah, Mohammed

doi:10.5144/0256-4947.2007.437

Cited by 3 publications

(8 citation statements)

References 16 publications

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“…Mourad W et al found that in 98 liver transplants, 15 neoplasms (15.3%) were identified. 3 Patient ages ranged from 5 to 63 years (median, 56 years). The primary etiology of hepatic disease was hepatitis C virus in 12 cases, hepatitis B virus in 1 case, cryptogenic cirrhosis in 1 case and congenital hepatic fibrosis in 1 case.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological study of primary carcinoma of the liver

Dasharatham¹,

Kumar

2017

Int J Adv Med

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Background: Since the incidence of the primary carcinoma of the liver in Warangal is very high when compared to other parts of the country, the possible etiological factors have been studied for the increasing frequency of Primary carcinoma of the liver with a view for further follow up. The objective of the present study was to undertake a thorough study of histopathological changes, typing and its association with cirrhosis.Methods: A hospital based cross sectional study was carried for a period of three years among 56 cases of primary carcinoma of the liver at MGM hospital. Institutional Ethics Committee permission was obtained. Informed consent was taken from each and every patient. Detailed history, clinical examination and investigations were carried out for each and every included patient. Liver biopsy was done under strict aseptic precautions.Results: The incidence of Primary carcinoma of the liver was found to be highest in males as compared to females. The highest incidence of Primary carcinoma of the liver was found in the age group of 41-50 years. In only 14.3% of cases the Primary carcinoma of the liver was associated with cirrhosis of liver. The most common type of cell found on histopathology was cylindroids type in 35.7% of cases followed by trabecular type in 28.5% of cases.Conclusions: Incidence of Primary carcinoma of the liver was found to be very high. This was not associated with corresponding increase in cirrhosis. The cause of their increase was obscure.

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Section: Discussionmentioning

confidence: 99%

Clinico-pathological study of primary carcinoma of the liver

Dasharatham¹,

Kumar

2017

Int J Adv Med

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“…After performing our literature search, we identified risk factors relevant to HCC-CC, HCC alone and CC alone (12)(13)(14)(15)(17)(18)(19)(20)(21)(22). Among these risk factors, cirrhosis, hepatitis B virus (HBV) and hepatitis C virus (HCV) viral infections are evaluated risk factors for HCC-CC (12)(13)(14)(15)(17)(18)(19)(20).…”

Section: Variablesmentioning

confidence: 99%

“…Among these risk factors, cirrhosis, hepatitis B virus (HBV) and hepatitis C virus (HCV) viral infections are evaluated risk factors for HCC-CC (12)(13)(14)(15)(17)(18)(19)(20). For HCC alone, the aforementioned risk factors were included as were the following: portal hypertension, alcoholic fatty liver, aflatoxin, peliosis hepatitis, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), granulomatous hepatitis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hemochromatosis (HCM), glycogen storage disease, Wilson's disease, porphyria cutanea tarda (PCT), alpha-1 antitrypsin, tyrosinemia, portal vein thrombosis, Budd-Chiari syndrome.…”

Section: Variablesmentioning

confidence: 99%

“…Although this entity does demonstrate pathologic features of its well-established biphenotypic counterparts, the characteristics of this neoplasm make diagnosis challenging using conventional radiologic imaging and serologic markers. Moreover, accurate prognostic information is affected by the low frequency of this tumor, which restricts available clinical information even within Original Article A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma large medical centers (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

“…Prior studies have examined the role of cytoskeletal stability, apoptosis, and the inflammatory cascade in HCC-CC (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Additionally, as HCC-CC poses a diagnostic dilemma for radiologists, tumor specific biomarker may assist in the diagnosis of this neoplasm and prognostic assessment (23,24).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma

Mok

Mohan

Grewal

et al. 2016

J. Gastrointest. Oncol.

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Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease

Srinath¹,

Shneider²

2012

J. pediatr. gastroenterol. nutr.

117

100

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Objectives The published natural history of congenital hepatic fibrosis (CHF) was examined to inform clinical decision making in autosomal recessive polycystic kidney disease (ARPKD). Methods A systematic literature search of the data on CHF, ARPKD, Caroli disease, Caroli syndrome, and type V choledochal cyst was performed to extract data related to portal hypertension, infection, malignancy, mortality, and transplantation. Results Information related to 1230 patients with CHF was extracted from 155 articles. Median and mean age at diagnosis were 2 and 11.2 years, respectively. Median and mean time followed after diagnosis were 5.0 and 7.5 years, respectively (range 0–38 years). Sequelae of portal hypertension (n = 409), cholangitis (n = 152), and malignancy (n = 21) were noted. The nature of the portal hypertension was similar to that in other pediatric conditions (164 with varices, 74 bleeding varices, 81 underwent portosystemic shunting). Documented cholangitis was fatal in 3 of 23 children who were infected after renal transplantation. Twenty-one patients developed hepatobiliary cancer, with the majority having cholangiocarcinoma (n = 19). Cholangiocarcinoma (CCA) was predominant in individuals older than 40 years with either Caroli syndrome or isolated CHF, not ARPKD (median and mean age at CCA diagnosis were 70.3 and 60.1 years, respectively; range 33–75 years). There was a relative paucity of data on combined liver-kidney transplantation. Conclusions Clinical decision making in ARPKD should reflect an understanding of the potential issues emanating from CHF. Accepted pediatric specific approaches to portal hypertension are warranted but must take into consideration the stage of renal insufficiency and potential plans for renal transplantation. Cholangitis is a major issue and necessitates anticipatory guidance and awareness. CCA, although a dreaded complication, does not appear to be a major issue during childhood. The indications for liver and combined liver-kidney transplantation are controversial and warrant further analysis.

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Clinicopathologic features of hepatic neoplasms in explanted livers: a single institution experience

Cited by 3 publications

References 16 publications

Clinico-pathological study of primary carcinoma of the liver

Clinico-pathological study of primary carcinoma of the liver

A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma

Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease

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