Clinicopathologic findings in (anti‐FcepsilonR1alpha) autoimmune‐related chronic urticaria

Abstract

There were no significant histopathologic differences between the anti-IgE receptor Ab positive and negative cases. Therefore, serum testing for anti-IgE receptor Ab is required to identify this subgroup of chronic urticaria patients.

Omalizumab for the Treatment of Chronic Idiopathic Urticaria: Systematic Review of the Literature

“…Significant improvements associated with the therapy were noticed, without any particular adverse effects except for three episodes of hives that were easily managed. Similarly, a 15‐year‐old girl with an adverse reaction to aspirin as well as chronic rhinosinusitis, severe asthma, and CIU worsened by nonsteroidal anti inflammatory drug administration was treated with omalizumab 300 mg every 4 weeks for 6 months . A decrease in peripheral eosinophil count was noted at her monthly visit, with an improvement in spirometry parameters such as fractional exhaled nitric oxide and forced expiratory volume in the first second from baseline.…”

“…Similarly, a 15-year-old girl with an adverse reaction to aspirin as well as chronic rhinosinusitis, severe asthma, and CIU worsened by nonsteroidal anti inflammatory drug administration was treated with omalizumab 300 mg every 4 weeks for 6 months. 3 A decrease in peripheral eosinophil count was noted at her monthly visit, with an improvement in spirometry parameters such as fractional exhaled nitric oxide and forced expiratory volume in the first second from baseline. Further, subcutaneous symptoms were also improved, despite displaying a relapse of such symptoms just after 1 month of discontinuation of therapy, requiring systemic corticosteroid therapy to improve this condition.…”

“…Chronic idiopathic urticaria is typically considered to be caused by autoantibodies, but sometimes the cause is unknown, and features altered basophil phenotypes, whereas induced urticarias are mainly related to external triggers and include solar urticaria, heat urticaria, cold urticaria, contact urticaria, aquagenic urticaria, delayed pressure urticaria, vibratory urticaria, and cholinergic urticaria. In CIU, histamine, together with blood basophils, cutaneous mast cells, and immunoglobulin E (IgE), is thought to play a key role as a fundamental mediator; therefore, most treatments concerning this condition rely on antihistamine products.…”

Identification of a Th2‐ and Th17‐skewed immune phenotype in chronic urticaria with Th22 reduction dependent on autoimmunity and thyroid disease markers

“…As chronic urticaria has been associated with autoimmunity and thyroid disease, we also compared the helper T‐cell immune phenotype present within chronic urticaria lesions from patients with and without autoimmune antibodies and/or abnormal thyroid function test profiles. Recently, Rojanapremsuk et al compared histopathologic findings, including the presence of mast cells and the density of lymphocytic infiltration, in chronic urticaria patients with and without anti‐IgE receptor antibodies and found no significant difference in all microscopic features. In an earlier study, Sabroe et al compared the inflammatory infiltrate present in chronic urticaria lesions from patients with and without autoantibodies against FcϵR1 and/or IgE.…”

Preguntas comunes en alergias. Enfoque práctico para el diagnóstico y manejo en atención primaria

“…Las enfermedades más comunes desencadenadas por la hipersensibilidad tipo IV son la dermatitis de contacto y las reacciones cutáneas severas por medicamentos, entre las que están incluidos el Stevens-Johnson y la necrólisis epidérmica 17,18 y en las que pueden intervenir múltiples tipos celulares. 17,19,20,21 Adicionalmente, otros tipos celulares pueden participar en la respuesta, como eosinófi los, mastocitos, etcétera, lo que depende del tipo de estímulo que induce la respuesta y tendrá como consecuencia manifestaciones clínicas diferentes, pero que, por motivos desconocidos, suelen afectar de forma común la piel, entre otros órganos.…”