Clinicopathologic findings, sensitivity to house dust mites and efficacy of milbemycin oxime treatment of dogs withCheyletiellasp. infestation

Abstract

Twenty-three dogs with positive skin scrapings for Cheyletiella sp. were treated with milbemycin oxime using a protocol approximating 2 mg kg-1 orally once weekly for three weeks. Nineteen of these dogs belonged to a household of 41 dogs and two dogs were in households with one other dog. All in-contact dogs were treated. Pre-treatment intradermal skin tests showed positive reactions to D. farinae in 13 dogs and to D. pteronyssinus in 12 dogs; these became negative post-treatment in four and seven dogs, respectively. All dogs showed a dramatic reduction in clinical signs one week after the third treatment. Eighteen dogs no longer had mites on skin scrapings, three had dead mites and two had deformed eggs. Recurrence of clinical signs necessitated two additional courses of the protocol in the multiple dog household and for a dog receiving immunosuppressive treatment for pemphigus foliaceus. Possible adverse reactions to the milbemycin (vomiting, lethargy) were noted once in two dogs.

Parasitic Diseases

“…80 Pyrethrin -or pyrethroid -based shampoos, sprays, or spot -on formulations are effective for dogs, 81 but pyrethroids should not be used on cats. 82 All pets in the household should be treated at the same time. Multiple treatments may be required depending on the potential for reinfection from other animals or the environment.…”

Şeyletiella Dermatiti

“…Kedilerde C. blakeinin tespiti, kedinin tüylerinin taranması, firçalanması veya selofon bant yöntemi ile elde edilen toz ve kepeklerin mikroskopik incelemesi ile yapılır. Bazen akarlar direkt olarak siyah zeminde çıplak gözle de görülebilir 5,8 . Laboratuvarda bazı hastalarda kanda eozinofili bildirilmiştir 1 .…”

Systemic manifestations of Cheyletiella infestation in man

“…In one study, there were 23 privately owned dogs with proven cheyletiella dermatitis among which eight dogs had negativization from positive intradermal test reactions to Dermatophagoides sp . in the post‐treatment period 14 . Cross‐sensitivity between two infestations had been hypothesized.…”