Clinicopathologic Manifestations of Epstein-Barr Virus—Associated Cutaneous Lymphoproliferative Disorders

Iwatsuki, Keiji

doi:10.1001/archderm.1997.03890450023003

Cited by 97 publications

(57 citation statements)

References 24 publications

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“…Double infection with ATLV and EBV has been reported, 26,27 and Case 12 is suspected to be possibly infected in this manner. Many reports have described absolute presence of EBV, 16,17 low incidence 28,29 or its absence 20,30 in CTCL. Some of these data were analyzed using EBER probes labeled with alkaline-phosphatase or FITC.…”

Section: Detection Of Ebv Genomementioning

confidence: 99%

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

et al. 2001

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Section: Detection Of Ebv Genomementioning

confidence: 99%

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

et al. 2001

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“…HV-like eruption is a representative cutaneous manifestation of EBV-associated lymphoproliferative disorder and is reported mainly in Asia [4,13,14,15,16,17] and Latin America [18,19]. HV-like eruption has similar clinical and pathologic findings to those of HV.…”

Section: Discussionmentioning

confidence: 99%

“…Patients often complain of constitutional symptoms such as fever, fatigue and present hepatitis, hepatosplenomegaly and lymphadenopathy. The skin also can be infiltrated by EBV+ lymphocytes and shows variable features, depending on the interaction between virus-infected cells and host immune status [3,4]. …”

Section: Introductionmentioning

confidence: 99%

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Chronic Active Epstein-Barr Virus Infection-Associated Hydroa Vacciniforme-Like Eruption and Behçet's-Like Orogenital Ulcers

et al. 2013

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The cutaneous manifestations of chronic active Epstein-Barr virus (EBV) infection can be diverse. Among them, hydroa vacciniforme-like eruption is one of the best-known features. Although rare, mucosal ulcers have been reported to be associated with EBV as a result of primary infection or immune suppression. We describe a 65-year-old female with recurrent necrotic papulovesicles on the face and both arms for 2 years. She also complained of recurrent oral and genital mucosal ulcers developing simultaneously with skin eruptions. They appeared periodically during the spring and summer and were triggered or aggravated by sun exposure. Skin biopsies from the face and genitalia showed identical findings with dense lymphocytic infiltrations. In addition, in situ hybridization revealed EBV-positive lymphoid cells in both specimens. To our knowledge, this is the first case of serologically and pathologically proven chronic active EBV infection presenting hydroa vacciniforme-like eruption and orogenital ulcers at the same time in one patient.

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“…Different viruses have been proposed to have a role in the etiopathogenesis of CTCL, mainly the human T-cell leukemia virus and the Epstein-Barr virus [6,7]. Conflicting results have emerged from studies investigating the role of the Epstein-Barr virus in CTCL [8]. Our group demonstrated in other reports that the Epstein-Barr virus, parvovirus variants (B19, LaL1/K71, V9) and HHV-7 were not involved in the etiopathogenesis of CTCL [9,10].…”

Section: Introductionmentioning

confidence: 99%

Human Endogenous Retrovirus Expression in Primary Cutaneous T-Cell Lymphomas

Fava

Bergallo²,

Astrua³

et al. 2015

Dermatology

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Background: Mycosis fungoides (MF) and Sézary syndrome (SS) are the most frequent cutaneous T-cell lymphomas (CTCL). Human endogenous retroviruses (HERVs) were reverse transcribed and integrated into primate chromosomal DNA, becoming noninfectious, although various stimuli may reactivate them. HERV expression seems to be impaired in several human diseases but limited data regarding CTCL are available. Objective: To evaluate the endogenous retroviral transcription profile in CTCL and their expression among disease clinical stages. Methods: Peripheral blood mononuclear cells from 42 MF/SS patients were analyzed. Total RNA was extracted and amplified with reverse transcription polymerase chain reaction. Results were compared with those obtained in a cohort of 20 healthy donors. Results: HERVs were significantly overexpressed in MF/SS patients compared with healthy donors. No differences were found between early and advanced CTCL stages. Conclusion: HERVs can act as promoters in MF/SS pathogenesis. It remains to link HERV hyperexpression to the outcome in CTCL patients.

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Clinicopathologic Manifestations of Epstein-Barr Virus—Associated Cutaneous Lymphoproliferative Disorders

Cited by 97 publications

References 24 publications

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides

Chronic Active Epstein-Barr Virus Infection-Associated Hydroa Vacciniforme-Like Eruption and Behçet's-Like Orogenital Ulcers

Human Endogenous Retrovirus Expression in Primary Cutaneous T-Cell Lymphomas

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