Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience

Kim, Chul‐Hwan; Dancer, Jane; Coffey, Donna; Zhai, Qihui; Reardon, Michael J.; Ayala, Alberto G.; Ro, Jae Y.

doi:10.1016/j.humpath.2007.12.018

Cited by 92 publications

(82 citation statements)

References 11 publications

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“…Of the 26 cases (with information available) reported, 21 have originated in the heart (14 in the right atrium, 5 in left atrium, and 2 in left ventricle). This is similar to the 2:1 ratio (right to left ratio) reported by Kim et al 24 in their 10-year single-institution report of 24 primary cardiac sarcomas. In that series, 16 of 24 cases were right-sided lesions, with the atrium being the most commonly involved chamber (14 of 24 cases).…”

Section: Locationsupporting

confidence: 90%

Primary Cardiac Synovial Sarcoma

Varma¹,

Adegboyega²

2012

Archives of Pathology &Amp; Laboratory Medicine

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Primary cardiac synovial sarcoma is an uncommon malignant neoplasm, with only a handful of cases reported in the English literature to date. Synovial sarcomas have also been described at other unusual sites, such as the heart, pleuropulmonary region, kidney, prostate, liver, mediastinum, retroperitoneum, gastrointestinal tract, and peripheral nerve. For synovial sarcomas that arise at these unusual locations, definitive diagnosis is challenging and requires use of ancillary diagnostic procedures, such as immunohistochemistry, electron microscopy, and molecular genetic techniques, for confirmation of diagnosis. The nonrandom occurrence of t(X;18) has been found consistently in synovial sarcomas. It has also been found as a sole cytogenetic abnormality in some cases, suggesting it as a key molecular event in tumor development. This review highlights salient features of primary cardiac synovial sarcoma and the associated diagnostic challenges.

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Section: Locationsupporting

confidence: 90%

Primary Cardiac Synovial Sarcoma

Varma¹,

Adegboyega²

2012

Archives of Pathology &Amp; Laboratory Medicine

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“…Neoadjuvant chemoradiotherapy might shrink the tumor and thereby enable its resection. 8 However, in the event of initial misdiagnosis (as in our patient) and severe RV dysfunction requiring immediate surgery, there might not be time for neoadjuvant chemotherapy.…”

Section: A B D Cmentioning

confidence: 73%

“…7 Yet the clinical presentation is variable and metastases are present in 66% to 89% of patients at the time of diagnosis. 8 Echocardiography is a readily available nondiagnostic tool to detect these tumors, and a screening test in patients with varied presentations can aid in making a proper diagnosis. Meng and colleagues 9 reported that the sensitivities of TTE and transesophageal echocardiography in detecting these primary masses are 93% and 97%, respectively.…”

Section: A B D Cmentioning

confidence: 99%

Pulmonary Artery Sarcoma Masquerading as Chronic Pulmonary Thromboembolism

Coşkun¹,

Sinan²,

Calpar³

et al. 2014

Texas Heart Institute Journal

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We describe the case of a 60yearold woman who presented with pulmonary artery sarcoma, a very rare tumor of the cardiovascular system. Her tumor was initially misdiag nosed as chronic pulmonary thromboembolism, and she underwent pulmonary endarter ectomy.Early P ulmonary artery (PA) sarcoma, a very rare tumor of the cardiovascular system, is often misdiagnosed as acute or chronic pulmonary thromboembolism because its clinical presentation and radiologic findings resemble those of thromboembolism.1,2 The prognosis is usually poor: the tumor is invasive and often involves vital structures such as the heart, which makes radical resection challenging. 3 We describe the case of a 60-year-old woman with PA sarcoma that was initially misdiagnosed. Case ReportIn February 2013, a 60-year-old woman presented at our emergency department with progressive dyspnea and palpitation. The dyspnea had started after a long bus ride. Her New York Heart Association (NYHA) functional class was II/III. On physical examination, she was positive for jugular venous distention. Auscultation revealed a grade 3/6 systolic ejection murmur in the left parasternal and 2nd intercostal areas. Her hemodynamic state was stable. Her electrocardiogram showed sinus rhythm and a pattern of right ventricular (RV) strain. The patient's cardiothoracic ratio was greater than 50%, and her natriuretic pro-brain peptide level was high. Transthoracic echocardiography (TTE) and computed tomography (CT) of the chest showed RV dilation with impaired function and a mass (2.7 × 1.3-cm) extending from the pulmonary valve into the right and left PAs and into all sub-branches, which suggested a pulmonary embolus (Figs. 1 and 2). Systolic PA pressure (sPAP) derived by Doppler echocardiography was 122 mmHg. Laboratory investigations for hypercoagulable disorders were within normal limits. Malignancy was ruled out by positron emission tomography-CT (PET-CT). Doppler studies of the lower-extremity veins were normal. A diagnosis of subacute pulmonary thromboembolism was made on the basis of the patient's clinical presentation and imaging results, and we began anticoagulation with heparin. Thrombolytic therapy was not started because of her stable hemodynamic condition.Subsequently, the patient was placed on warfarin therapy for 3 months and monitored. Her echocardiogram revealed a dilated RV with reduced systolic function and moderate tricuspid regurgitation, no decrease in the size of the mass, and normal left ventricular function. Her sPAP was 122 mmHg. Computed tomograms of her chest showed web-like filling defects in the pulmonary vasculature on the right and left lower lobes, arising from a pulmonary-valve condition that was consistent with

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“…In humans, benign cardiac tumours are more frequent than malignant ones, with myxomas being the most common benign neoplasms and myxosarcomas, HSA or non-differentiated sarcomas being the most common malignant tumours (Lam et al, 1993;Kim et al, 2008;Kumar et al, 2012;Wang et al, 2012). The Acta Veterinaria Hungarica 64, 2016 studies of Ware and Hopper (1999) and Aupperle et al (2007) show that among tumours diagnosed in dogs post mortem, malignant tumours are more frequent, with HSA and ABT being the most common.…”

Section: Discussionmentioning

confidence: 99%

“…HSA, as a prevalent tumour both in humans and in dogs, was examined for the expression of several cell markers including but not restricted to CD31, FVIIIRA, Ki-67, p53 protein, vimentin, SMA, desmin, S-100 protein, actin, and CD117 (Ferrer et al, 1995;Bertazzolo et al, 2005;Kim et al, 2008;Sabattini and Bettini, 2009;Ge et al, 2011).…”

mentioning

confidence: 99%

Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014

Janus

Nowak

Noszczyk-Nowak

et al. 2016

Acta Veterinaria Hungarica

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Primary heart tumours affect less than 1% of dogs. Due to their rare incidence, every research showing the frequency of cardiac tumours is valuable. Routine diagnostics is often complemented with immunohistochemical analysis. This study was conducted on 110 patient records from all veterinary faculties in Poland from dogs diagnosed with heart tumours between 1970 and 2014. The dogs' age, breed and sex with tumour localisation and histopathological diagnosis were analysed. Because of its most common incidence, samples of haemangiosarcoma underwent further examination with assessment of the expression of cell markers that have not been evaluated earlier (i.e. minichromosome maintenance proteins and beta-catenin). We noted 111 tumours including 88.3% malignant and 10.8% benign ones. Haemangiosarcoma and aortic body tumour were the most frequent cardiac neoplasms in the dogs examined (45.9% and 27.9% of all tumours, respectively). Immunohistochemical analysis of haemangiosarcoma showed a positive expression of all markers examined. CD31, vimentin, and beta-catenin showed a positive reaction in all 11 samples examined. At least one proliferative marker (Ki-67, MCM-3 or MCM-7) showed a positive reaction in each sample. MCM-3 showed a higher expression than the two other proliferative markers (P = 0.006), but only Ki-67 showed a positive correlation with the mitotic index (P < 0.05, r = 0.89). Although beta-catenin, MCM-3 and MCM-7 showed a positive reaction in the haemangiosarcomas examined, their usefulness as diagnostic and prognostic factors should be a topic of further research.

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Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience

Cited by 92 publications

References 11 publications

Primary Cardiac Synovial Sarcoma

Primary Cardiac Synovial Sarcoma

Pulmonary Artery Sarcoma Masquerading as Chronic Pulmonary Thromboembolism

Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014

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