Clinicopathologic study of malignant ovarian tumors: A study of fifty cases

Chandanwale, Shirish S; Jadhav, Rakesh R.; Rao, Ruby; Naragude, Piyusha; Bhamnikar, Sunita; Ansari, Jehan Nizam

doi:10.4103/mjdrdypu.mjdrdypu_41_17

Cited by 9 publications

(7 citation statements)

References 2 publications

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“…This delay between the onset of symptoms and diagnosis may belong to the natural and type of tumors as most of these cases that present late belong to serous type carcinoma. The laterality were similar to the studies conducted by Chandanwale et al 6 and Manoja et al 29 in that most of the malignant tumors were unilateral . The presented study shows more than half of malignant tumors larger than 10 cm in diameter and this findings were in accordance with study done by Garg et al 28 .…”

Section: Discussionsupporting

confidence: 90%

Clinicopathological Study Of Primary Malignant Ovarian Tumors

Mohammed¹,

Alazzo²

2022

Ann Coll Med Mosul

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Background: Ovarian cancer is third gynecologic cancer after uterine and cervical cancer . It is heterogeneous disease with different in clinical features and outcome. It is a group of many subtypes with variation in biological features that lead to differences in response to treatments, survival and recurrence rates.Aim: This study aims to detect the frequency of histological types of primary malignant ovarian tumors and to find it's clinicopathological correlation. Subject and Methods:The retrospective cross sectional study done from 1 st of July 2020 to 1 st August 2020 on data of forty cases of primary malignant ovarian tumors who were diagnosed during the last three years (from 2017 to 2020) in Mosul hospitals labs and private labs. Results: Two thirds of cases 72.5% were surface epithelial tumors , followed by germ cell tumors 15% and sex cord-stromal tumors 12.5% .The serous cystadenocarcinoma was the most common histological type in this study .About one third of the cases 30 %were seen in 51-60 years of age group, most of tumors unilateral with solid cystic in nature .The largest diameter shows in mucinous adenocarcinoma . Pelvic mass was the most presenting sign of ovarian cancer . Conclusion: Malignant surface epithelial tumors comprises the most common type of ovarian cancer and of which serous carcinoma considered the main subtype followed by mucinous cystadenocarcinoma . Advancing age increased the possibility of malignant transformation and most of cases occur over 50 years old especially the cases of surface epithelial type , most of tumors unilateral with solid cystic in nature , pelvic mass was the most presenting sign of ovarian cancer .

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Section: Discussionsupporting

confidence: 90%

Clinicopathological Study Of Primary Malignant Ovarian Tumors

Mohammed¹,

Alazzo²

2022

Ann Coll Med Mosul

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“…12 However, Shirish et al in their study of malignant ovarian tumours reported much lower bilateral involvement of the ovaries (8%). 13 Whereas, Manoja et al reported 7.5% bilateral affectation for benign ovarian tumours, but up to 25% in malignant tumours of the ovary in their series. 10 Here in Nigeria, Ajani et al in Ibadan, Southwest, reported a fifty per cent incidence of bilateral ovarian tumours, though the study was on metastatic ovarian tumours.…”

Section: Discussionmentioning

confidence: 90%

“…21 Other benign tumours seen in this report were serous cystadenoma, benign Brenner tumour, mucinous cystadenoma and fibroma/thecoma, in quite a similarity to the study by Agrawal et al 22 Among malignant tumours, serous cystadenocarcinoma; a malignant surface epithelial tumour predominated other tumours such as immature teratoma, choriocarcinoma and mucinous cystadenocarcinoma. Serous cystadenocarcinoma was similarly reported as the dominant malignant tumour in an Indian population by Shirish et al 13 The reactive lesions were dominated by the functional cysts removed to relieving pain and associated discomfort and more importantly to rule out more serious inflammatory or neoplastic lesions with debilitating consequences. 1,4 These cysts are usually multiple ranging in size from regular less than two centimetres to larger ones causing abdominal swelling and discomfort, sometimes for the functional ones causing menstrual irregularities.…”

Section: Discussionmentioning

confidence: 95%

Histopathologic pattern of ovarian masses in Usmanu Danfodiyo university teaching hospital, Sokoto, Nigeria

Bello

Gambo²,

Ibrahim³

et al. 2021

IJPO

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Diseases of the ovary are diversely arising from the different parenchymal tissue components. This span between reactive functional cysts to more debilitating ovarian carcinoma. Ovarian carcinoma is the sixth most common cancer and one of the leading cause of cancer death among female. This study aims to determine the epidemiological and histopathological patterns of ovarian masses in our setting.The study material was all the ovarian tissues biopsy specimen submitted to the Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto over five years. These were fixed in 10% formal saline embedded in paraffin wax, tissue blocks formed and were sections and stained with hematoxylin and eosin on the glass slides. Request cards and case folders were used to extract clinical information. These were reviewed, analysed and presented as frequency distribution figures.There were 112 ovarian biopsies during the study period. Their ages ranged between 13 and 67 years and peaked in the fourth decade of life. Fifty per cent of all the cases were seen between the ages of 21 and 40 years. Benign neoplastic diseases formed 50% of the ovarian masses and matured cystic teratoma was the most common. Others were reactive and functional ovarian cysts (24.1%), malignant neoplastic conditions (14.3%) and inflammatory / infectious diseases (11.6%). Overall mature cystic teratoma constitutes 27% of the entire ovarian masses. Matured cystic teratoma was the most common disease of the ovary in our setting, afflicting young female, while malignant tumours dominated by serous cystadenocarcinoma affect the older age group. The fourth decade of life was the most common age of affectation. We advocate for proper histopathologic evaluation of all ovarian masses to arrive at a definitive diagnosis to offer an appropriate treatment modality.

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“…14 The most frequent histologic subtype was the serous type, followed by mucinous and endometrioid types, similar to other studies. 13,15 It has been observed that patients with OCs may have symptoms for several months before their diagnosis. [16][17][18] In this study, we observed that abdominal distension and gastrointestinal disturbances were the most frequent symptoms.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Treatment and Outcomes in Epithelial Ovarian Cancer: A Retrospective North Indian Single-Institution Experience

Meena

Zahoor

Guru

et al. 2022

JCO Global Oncology

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PURPOSE Ovarian cancer (OC) is ranked as the third most common gynecologic cancer in various Indian cancer registries. In India, OC is seen in the younger age group, with a median age < 55 years being reported by most of the studies. The majority of patients are diagnosed in advanced stage (70%-80%), where the long-term (10-year) survival rate is poor, estimated at 15%-30%. The aim of this study was to evaluate clinical epidemiology, treatment patterns, and survival outcomes in patients with epithelial OC. METHODS This was a retrospective analysis of patients with epithelial OC who were treated at Sher-i-Kashmir Institute of Medical Sciences, Srinagar, over a period of 9 years, from January 2010 to December 2018. RESULTS OC constituted 2.94% of all cancers registered. Epithelial OC constituted 88.4% of all OCs, with a median age 50 years. More than two third of patients belonged to rural background and the majority (76.9%) of the patients were in stage III or IV at the time of diagnosis. The main presenting symptoms were abdominal distension/bloating (46.5%) and gastrointestinal disturbances (35.2%). The most common histologic types were serous (65.9%) followed by mucinous carcinoma (15%). Median overall survival for the whole study cohort was 30 months (95% CI, 28.0 to 31.9). Median overall survival for stage I, II, III, and IV was 72, 60, 30, and 20 months, respectively. CONCLUSION Most of the patients presented in advanced stage of the disease and have poor outcome. Delay in diagnosis and improper management before registering in tertiary cancer center and lack of tertiary care facilities are the root causes of poor outcomes. The general population and primary care physicians need to be made aware of OC symptoms.

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Clinicopathologic study of malignant ovarian tumors: A study of fifty cases

Cited by 9 publications

References 2 publications

Clinicopathological Study Of Primary Malignant Ovarian Tumors

Clinicopathological Study Of Primary Malignant Ovarian Tumors

Histopathologic pattern of ovarian masses in Usmanu Danfodiyo university teaching hospital, Sokoto, Nigeria

Patterns of Treatment and Outcomes in Epithelial Ovarian Cancer: A Retrospective North Indian Single-Institution Experience

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