Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses

Carneiro, Mailon Cury; Quenta-Huayhua, Milenka Gabriela; Peralta-Mamani, Mariela; Honório, Heitor Marques; Santos, Paulo Sérgio da Silva; Rubira-Bullen, Izabel Regina Fischer; Rubira, Cássia Maria Fischer

doi:10.1007/s12105-023-01543-z

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Plaques, ulcerations, and crusts may appear in more advanced cases. The lesion may progress to squamous cell carcinoma if treatment is not set [ 5 ]. Individuals, mainly men with light skin who work outside (farmers, fishermen, builders, and sportsmen) are most affected by this condition [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Lichen Planus of the Lip—Case Series and Review of the Literature

Marcu (Selaru),

Parlatescu,

Tovaru

et al. 2024

Medicina

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Background and Objectives: Lichen planus of the lip (LPL) is a chronic inflammatory condition that resembles actinic cheilitis, discoid lupus erythematosus, graft-versus-host disease, and lichenoid reaction to dental materials or drugs. The purpose of this study was to conduct a literature review on lichen planus lip involvement and to report a retrospective observational study that characterises and explores the clinical, histopathological, and evolution of the lesions in a group of patients with unique involvement of LPL. Materials and Methods: Clinical data of patients diagnosed with LPL was retrieved from the medical charts of the patients referred to the Oral Pathology Department of the “Carol Davila” University of Medicine and Pharmacy. A concurrent electronic literature research was carried out using PubMed and Web of Science from 2003 to 2023. Results: Eleven patients diagnosed with unique LPL were analysed (male/female ratio was 1.75, mean age 63.64 years ± 12.52). All patients presented lesions of the lower lip; the clinical forms were atrophic (six cases) and erosive (five cases), and the histopathological exam confirmed the diagnosis. After topical treatment with corticosteroids, most of the patients had complete remission. The literature review revealed 24 studies (sixteen case reports and eight case series) which comprised 84 patients. Isolated lip involvement was reported in 17 studies, and five articles with concomitant oral lichen planus, while two articles did not mention this criterion. Conclusions: Our study brings new data on isolated lichen planus of the lip that primarily affects the lower lip with predominance in male patients. It was reported worldwide in patients between 22 and 75 years old. Topical corticosteroids were the main treatment prescribed and they usually brought remission of the lesions. Lichen planus of the lip is a challenging diagnosis for oral health practitioner providers as well as for dermatologists.

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Section: Introductionmentioning

confidence: 99%

“…Additionally, it is more frequently noticed in men as they utilise lip balm less frequently than women do [ 7 ]. Because the lesion progresses slowly and normally shows no symptoms, it is sometimes mistakenly associated with ageing conditions [ 5 ]. The primary risk factor for AC is chronic sunlight exposure.…”

Section: Introductionmentioning

confidence: 99%

Lichen Planus of the Lip—Case Series and Review of the Literature

Marcu (Selaru),

Parlatescu,

Tovaru

et al. 2024

Medicina

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Randomized Clinical Trial of Imiquimod Compared With Fludroxycortide in the Treatment of Actinic Cheilitis

Fumagalli,

Cherubini,

Spanemberg

et al. 2024

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Diseases with oral malignant potential: Need for change to inform research, policy, and practice

Celentano,

Cirillo

2024

J Oral Pathology Medicine

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This manuscript critically examines the current classification of oral potentially malignant disorders, questioning the practicality and implications of labeling such a large population as precancerous, given that the actual progression to oral cancer is significantly low for most disorders. The paper advocates for a revised classification system that accurately reflects the varying malignancy risks associated with different disorders. It suggests a reassessment of the diagnostic and management approaches to mitigate overdiagnosis and alleviate patient burdens. We propose categorizing diseases with oral malignant potential as follows: Oral Precancerous Diseases, encompassing high‐risk lesions and conditions like erythroplakia, non‐homogeneous leukoplakia, proliferative leukoplakia, and actinic keratosis; Oral Potentially Premalignant Diseases, covering lesions, conditions, and systemic diseases with distinct oral manifestations harboring a limited or undefined risk of transformation, such as homogeneous leukoplakia, oral submucous fibrosis, oral lichenoid diseases, chronic hyperplastic candidosis, keratosis of known aetiology (smokeless tobacco, khat), palatal lesions in reverse smokers, and dyskeratosis congenita; and Systemic Conditions with Oral Malignant Potential including Fanconi's anemia, xeroderma pigmentosum, and chronic immunosuppression (including patients post‐bone marrow transplantation), which are associated with an increased risk of oral cancer without preceding precursor lesions. We provide illustrative examples to demonstrate how this framework offers practical guidance for research, policy‐making, and clinical practice.

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Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses

Cited by 4 publications

References 40 publications

Lichen Planus of the Lip—Case Series and Review of the Literature

Lichen Planus of the Lip—Case Series and Review of the Literature

Randomized Clinical Trial of Imiquimod Compared With Fludroxycortide in the Treatment of Actinic Cheilitis

Diseases with oral malignant potential: Need for change to inform research, policy, and practice

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