Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population

Abstract

BackgroundThis study was carried out to establish the relative incidence and provide clinico-pathologic information on the various histological types of ameloblastoma seen at the Obafemi Awolowo University Teaching Hospital complex, Ile-Ife in order to provide a baseline data which will be of significance to the pathologist and clinician.MethodsClinico-pathologic data on a total of 77 histologically diagnosed cases of ameloblastoma archieved at the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife over a 15 year period were obtained and analysed descriptively.ResultsFollicular ameloblastoma was the most common histological type (50 cases, 64.9%), followed by plexiform ameloblastoma (10 cases, 13.0%). 4 (5.2%) cases of desmoplastic and 3 (3.9%) cases of acanthomatous ameloblastoma were seen while the basal cell variant accounted for 2 (2.6%) cases. Only 1 case of the unicystic type was seen. Some of the 77 cases presented as a mixture of two or more histological types. Ameloblastoma occurred over an age range of 11 to 70 years with a peak age incidence in the 3rd decade.ConclusionThis study provides a baseline data on variants of ameloblastoma as obtained in a suburban Nigerian population. Since variants of ameloblastoma differ in biologic behaviour, the data collected in this study provides clinicopathologic information which is of significance to the pathologist and clinician.

Ameloblastomas sólidos: estudo retrospectivo clínico e histopatológico em 54 casos

“…Solid ameloblastomas affect the mandible prefferably 1,2,14,15 , especially the posterior region 1,15 , with a proportion between the gnathic bones of 1:5.4 16 . Our results corroborate the fact that these lesions have a predilection for the posterior mandible.…”

“…Numerous histological patterns can be seen in these lesions, such as: follicular, plexiform, acanthomatous, desmoplastic, basal cells and granular 2 . Up to 1992, the World Health Organization (OMS) recognized the existence of 3 distinctive clinicopathologic variants of ameloblastoma, called conventional solid ameloblastoma, unicystic ameloblastoma and peripheral ameloblastoma 3 .…”

Basal cell ameloblastoma–review of literature with report of three cases

“…The basal cell variant of ameloblastoma accounts for only 2% of the histologic types 1 and majority of the cases have been shown to occur in the mandible. 2 Apart from the primary manifestation as basal cell amelo blastoma, a desmoplastic ameloblastoma can also convert into a more aggressive basal cell ameloblastoma as reported by Makoto Hirota. 3 One of the cases in our series started as dentigerous cyst and later progressed to basal cell ameloblastoma.…”

Management techniques of ameloblastoma: a literature review

“…It is usually characterized as a benign epithelial odontogenic tumor with no ectomesenchymal element. It also has a local invasive behavior and a high recurrence rate 9 . With respect to its pathogenesis, the literature reports that this lesion probably develops from residual cell proliferation of the enamel organ.…”