Clinicopathological and Immunohistochemical Characteristics of Verruciform Xanthoma of the Lower Gingiva: A Case Report

Kimura, Masashi; Ohto, Hiroyuki; Shibata, Akio; Enomoto, Atsushi; Umemura, Masayuki

doi:10.7860/jcdr/2016/15446.7950

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Histopathological and immunohistochemical examination in one earlier study of the basement membrane in the epithelium in cases of VX revealed a tendency toward blurring, partial denaturation, and disappearance in cases of inflammatory cell infiltration 22) . Some studies have also reported that no foam cells were observed in VX scrape cytology specimens 8,28) . This suggests that VX should be considered as a potential diagnosis, even in the absence of foam cells when confronted with granulating or verruciform lesions accompanied by minor atypia.…”

Section: Discussionmentioning

confidence: 98%

Verruciform Xanthoma with Equivocal Exfoliative Cytological Diagnosis

Onda

Hayashi

Shiraishi

et al. 2018

Bull. Tokyo Dent. Coll.

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Verruciform xanthoma (VX), a papillary or wart-like lesion of the mucosa, is histopathologically characterized by papillary projection of the epithelium and an aggregation of foam cells in the lamina propria. Here, we describe a case of VX in the posterior mandibular gingiva, initially suspected to be a benign lesion based on clinical findings and cytology prior to an excisional biopsy. The patient was a 62-year-old man who had visited a local dentist approximately 1 year earlier, presenting with a white lesion in the left posterior mandibular gingiva that resisted removal by scraping. The lesion was left untreated as there were no subjective symptoms. Thereafter, the surface of the lesion roughened and the patient was referred to our department for a comprehensive examination. A circumscribed, granular mass, 15-mm in diameter, with a red and white surface was observed in the left posterior mandibular buccal gingiva. Exfoliative cytology was performed. The diagnosis was a class III lesion. Excisional biopsy was performed under local anesthesia. Histopathological examination led to a diagnosis of VX. At 1 year postoperatively, the patient is making satisfactory progress without recurrence. Verruciform xanthoma is difficult to diagnose preoperatively, and is commonly resected under a clinical diagnosis of papilloma or benign tumor. A benign lesion was also initially suspected in the present case and cytological analysis performed to confirm absence of malignancy. The lesion could not be diagnosed as VX preoperatively. Verruciform xanthoma can be over-diagnosed based solely on cytological examination because it often involves cellular atypia reflecting its characteristic extension of rete pegs and keratinization of surface cells, indicating the need for care in arriving at a definitive diagnosis.

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Section: Discussionmentioning

confidence: 98%

Verruciform Xanthoma with Equivocal Exfoliative Cytological Diagnosis

Onda

Hayashi

Shiraishi

et al. 2018

Bull. Tokyo Dent. Coll.

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“…Segundo a análise histopatológica, três tipos de xantoma verruciforme são reconhecidos com base na arquitetura microscópica da superfície. Embora o Tipo C (tipo plano), que apresenta acantose leve, alongamento variável das criptas epiteliais e uma fina camada de paraqueratose, seja apontado como o mais frequente, 2,12 o caso relatado foi identificado como Tipo A (tipo verrucoso), que apresenta hiperparaceratose, acantose e alongamento das criptas epiteliais, sendo evidenciado no exame histopatológico acantose e extensa hiperqueratinização do epitélio pavimentoso estratificado, com projeções alongadas em direção à lâmina própria.…”

Section: Discussão E Conclusõesunclassified

Xantoma verruciforme no palato duro: Caso clínico

Machado¹,

Oliveira²,

Lima³

et al. 2022

j.rpemd

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O xantoma verruciforme é uma lesão benigna rara que afeta principalmente a mucosa oral. O objetivo deste trabalho é relatar um caso de xantoma verruciforme em palato duro, destacando as características clínicas, histológicas e abordagem cirúrgica. A paciente do sexo feminino, de 62 anos, apresentava uma lesão nodular circunscrita, exofítica, de base séssil e superfície papilar, com coloração esbranquiçada ao centro e rósea ao redor, de consistência firme e assintomática à palpação, com aproximadamente dez anos de evolução. A excisão cirúrgica foi o tratamento de eleição. A abordagem cirúrgica apresentou eficácia no tratamento sem ocorrência de recidiva da lesão após 16 meses de acompanhamento.

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Histogenetic Study of Verruciform Xanthoma of the Gingiva

Yamamoto¹,

Kawai²

2018

J Cytol Histol

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Clinicopathological and Immunohistochemical Characteristics of Verruciform Xanthoma of the Lower Gingiva: A Case Report

Cited by 5 publications

References 9 publications

Verruciform Xanthoma with Equivocal Exfoliative Cytological Diagnosis

Verruciform Xanthoma with Equivocal Exfoliative Cytological Diagnosis

Xantoma verruciforme no palato duro: Caso clínico

Histogenetic Study of Verruciform Xanthoma of the Gingiva

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