Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid–polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model

Sengel-Türk, Ceyda Tuba; Alçığır, Mehmet Eray; Ekim, Okan; Bakar‐Ates, Filiz; Hasçicek, Canan

doi:10.1016/j.ejpb.2020.10.016

Cited by 11 publications

(4 citation statements)

References 47 publications

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“…Currently two conventional therapeutic agents are available for treating BPH such as α-adrenergic blockers like doxazosin, terazosin and tamsulosin which help in relaxation of smooth muscle in the prostate and bladder neck to improve urinary flow and 5α-reductase inhibitors such as finasteride and dutasteride are used for the treatment of BPH. [18,22,23] However, long term use of these drugs leads to unpleasant side effects like erectile dysfunction, loss of libido, dizziness, upper respiratory tract infection, gynacomastia, impotence, chest pain etc its use is restricted. [24,25] Therefore phytotherapeutic and pharmaceutical agents of plant origin have proven to be an effective treatment option in BPH patients with low cost and minimal side effects.…”

Section: Discussionmentioning

confidence: 99%

“…The ventral lobe of the prostate were fixed in 10% neutral buffered formaldehyde solution, dehydrated in graded alcohol, embedding in paraffin wax, cut into 5µm thick section and stained with hematoxyline and eosin. [18] The section were mounted with DPX and coverslip, examined and photographed under Leica DM2000 LED microscope for recording any histological changes.…”

Section: Histological Analysismentioning

confidence: 99%

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Relative Influence of Ageratum conyzoides L. Plant Extracts on Testosterone Induced Benign Prostatic Hyperplasia in Mice

Jomba¹,

Bharali²

2022

Pharmacogn. Res.

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The present study was designed to investigate the inhibitory efficacy of aqueous and ethanolic extracts of Ageratum conyzoide L. (AC, Family asteraceae) on testosterone induced BPH in male mice. Materials and Methods: Mice were randomly divided into five groups (n=6): negative control group received corn oil, BPH model group receive testosterone (5mg/kg/day, S.C) dissolved in corn oil. Another group received standard BPH drug finasteride (5 mg/Kg/day, I.P) along with testosterone injection (5mg/kg/day, S.C). The other two group of animals received either aqueous or ethanolic AC plant extracts (100, 500. 1000 and 2000 mg/kg, I.P) along with testosterone (5mg/kg/day, S.C) consecutively for 28 days. All animals were sacrificed at the end of the study period and prostate weight and prostatic index were determined, followed by histolopathological examination of the prostate gland. Results: The result of the present study indicated that treatment with either plant extracts caused significant reduction in prostate weight and prostatic index when compared to only testosterone treated animal group. The percentage of inhibition of prostate growth was found to be correlated in a dose dependent manner in plant extract treated groups. Histopathological examination of prostate gland revealed AC plant extracts treatment significantly reduced the glandular hyperplasia, epithelial thickness and stromal hyperplasia in the prostate gland of the treated animals. No significant elevation in serum ALT and creatinine level was recorded in any groups during the study period. Conclusion:This study hence indicate the therapeutic potential in Ageratum conyzoides L. plant extract in testosterone induced BPH model in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Histological Analysismentioning

confidence: 99%

Relative Influence of Ageratum conyzoides L. Plant Extracts on Testosterone Induced Benign Prostatic Hyperplasia in Mice

Jomba¹,

Bharali²

2022

Pharmacogn. Res.

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“…We begin this section by noting that this technique, shown in Figure 4, has prevailed over the evaporation of emulsifiers. In this modified technique, which combines the nanoprecipitation technique with the concept of self-assembly, the main aspect is that the active molecules and the polymers are dissolved in a water-miscible solvent such as acetone [42,43], ethanol [44], or acetonitrile [45]. Then, this solution is added to the aqueous solutions of lipids (e.g., PEG -conjugated or -unconjugated phospholipids) with continuous stirring, whereupon the lipid molecules and polymer particles spontaneously self-assemble in the solution (the lipid concentration in the solution should be high enough to surround the polymer core) [46].…”

Section: Modified Nanoprecipitation Techniquementioning

confidence: 99%

“…The release studies are performed with the nanocarrier prepared and characterized in the manner described previously. By definition, this parameter essentially refers to the amount of drug released per unit of time from the CSHN systems and can be determined using dialysis membrane (also known as the static method) [53] and ultracentrifugation [42]. These assays are endpoint assays in which the drugs released from the nanocarriers are collected at a series of time points and then quantified using UV-Vis and HPLC, as mentioned earlier.…”

Section: Insert Figurementioning

confidence: 99%

The state of the art in core-shell type lipid polymer hybrid nanocarriers and beyond

Sengel-Türk

Alptürk

2022

Preprint

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The need to enhance the therapeutic effect of drugs and thus reduce their side effects is the reason for the emergence of today's drug delivery systems. With the advent of nanotechnology, numerous molecular structures - from carbon nanotubes to polymeric materials - have been developed, and significant progress has been made. However, all these promising results do not mean that drug delivery systems are a solution to all problems in pharmaceutical technology. This is because any drug delivery system, while having its advantages, also suffers from certain limitations. Therefore, new and hybrid structures are created by combining different materials. In this respect, lipid-polymer hybrid particles emerged as a core-shell structure, where the polymer core is covered with a layer of phospholipids, and have attracted attention in the academic community. This manuscript, which provides an overview of the fundamentals of these molecular architectures, begins with a description of lipid-polymer hybrid particles. Conventional and unconventional production methods for fabricating these structures are then described. This is followed by a section discussing how the physical properties of these particles are characterized and how the physical properties affect pharmaceutical activity. The final section discusses prominent examples from the literature.

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A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective

Mal

Malik

Mahapatra

et al. 2022

Drug Development Research

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With different nitrogen-containing heterocyclic moieties, Indazoles earn one of the places among the top investigated molecules in medicinal research. Indazole, an important fused aromatic heterocyclic system containing benzene and pyrazole ring with a chemical formula of C 7 H 6 N 2 , is also called benzopyrazole. Indazoles consist of three tautomeric forms in which 1H-tautomers (indazoles) and 2H-tautomers (isoindazoles) exist in all phases. The tautomerism in indazoles greatly influences synthesis, reactivity, physical and even the biological properties of indazoles.The thermodynamic internal energy calculation of these tautomers points view 1H-indazole as the predominant and stable form over 2H-indazole. The natural source of indazole is limited and exists in alkaloidal nature (i.e., nigellidine, nigeglanine, nigellicine, etc.) found from Nigella plants. Some of the FDA-approved drugs like Axitinib, Entrectinib, Niraparib, Benzydamine, and Granisetron are being used to treat renal cell cancer, non-small cell lung cancer (NSCLC), epithelial ovarian cancer, chronic inflammation, chemotherapy-induced nausea, vomiting, and many more uses. Besides all these advantages regarding its biological activity, the main issue about indazoles is the less abundance in plant sources, and their synthetic derivatives also often face problems with low yield. In this review article, we discuss its chemistry, tautomerism along with their effects, different schematics for the synthesis of indazole derivatives, and their different biological activities.

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Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid–polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model

Cited by 11 publications

References 47 publications

Relative Influence of Ageratum conyzoides L. Plant Extracts on Testosterone Induced Benign Prostatic Hyperplasia in Mice

Relative Influence of Ageratum conyzoides L. Plant Extracts on Testosterone Induced Benign Prostatic Hyperplasia in Mice

The state of the art in core-shell type lipid polymer hybrid nanocarriers and beyond

A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective

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