Clinicopathological and outcome analysis of adult lupus nephritis patients in China

Tang, Yi; Zhang, Xiaoyan; Ji, Ling; Mi, Xuhua; Liu, Fei; Yang, Lichuan; Qin, Wei

doi:10.1007/s11255-014-0903-y

Cited by 32 publications

(42 citation statements)

References 25 publications

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“…Hypertension, serum creatinine level, hypocomplementemia, renal proliferative lesion, SLEDAI score, age, male gender, and proteinuria were identified as independent risk factors for poor prognosis of LN patients in different studies. [ 8 – 10 ] In the present study, we found that several clinical indexes, that is, nephrotic syndrome and low eGFR at diagnosis, were also risk predicting factors. These findings were consistent with results from observational studies.…”

Section: Discussionsupporting

confidence: 57%

Development and validation of a prediction score system in lupus nephritis

Tang

Qin²,

Peng³

et al. 2017

Medicine

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The risk assessment for developing end-stage renal disease (ESRD) remains unclear in patients with lupus nephritis (LN). The purpose of this study was to develop and validate a prediction rule for estimating the individual risk of ESRD in patients with LN using clinical and pathological data.A total of 599 patients with LN diagnosed by renal biopsy between June 2009 and June 2014 in West China Hospital of Sichuan University were retrospectively followed. Patients were randomly divided into derivation cohort (n = 379) and validation cohort (n = 220). The SLEDAI score was used to evaluate the clinical disease activity. Pathological lesions according to the International Society of Nephrology and the Renal Pathology Society (ISN/RPS) systems were meticulously evaluated. The risk factors for developing ESRD were evaluated using a Cox proportional hazard model with a stepwise backward elimination method.In the derivation cohort, 100 patients (26.5%) developed ESRD during the average 46.0 ± 21.1 months’ follow-up. The final prediction model included cellular crescents, active index >20, glomerular sclerosis, fibrous crescents, interstitial fibrosis, chronic index >5, nephrotic syndrome, and eGFR <45 mL/min as independent risk factors for developing ESRD. To create a prediction rule, the score for each variable was weighted by the regression coefficients calculated using the relevant Cox model. The prediction rule was validated in the validation cohort. During the follow-up period, 45 patients (21.5%) in validation cohort progressed to ESRD.This study developed and validated a new prediction rule using clinical measures and pathological changes for developing ESRD in patients with LN.

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Section: Discussionsupporting

confidence: 57%

Development and validation of a prediction score system in lupus nephritis

Tang

Qin²,

Peng³

et al. 2017

Medicine

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“…Lupus nephritis-IV (DPLN) is the most common, severe, and active form of nephritis; the prognosis of these classes of patient is directly proportional to the period of diagnosis and initiation of effective therapy [ 3 , 4 ]. A recent large clinical study of LN has suggested that patients with LN-II and LN-III classes have favorable outcome whereas patients with LN-IV, LN-V, and LN-VI have poorer outcomes [ 5 ], which further emphasizes that early detection of active forms of LN is valuable fortitude to decrease the morbidity and mortality. Presently, renal biopsy provides information on the level of renal tissue injury, pathological activity, and severity of renal disease.…”

Section: Introductionmentioning

confidence: 99%

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Sigdel

Duan

Wang

et al. 2016

Mediators of Inflammation

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by aberrant T cell immune response. Diffuse proliferative lupus nephritis (LN-IV) is the most common, severe, and active form of lupus nephritis. In this study, we investigated the production of Th1, Th2, and Th17 cytokines in prediction of active form of LN-IV. ProcartaPlex multiplex immunoassays panels were used for detection of serum Th1, Th2, and Th17 cytokines profiling. Th1 and Th17 cytokines (IL-18, IFN-γ, IL-12p70, IL-6, and IL-17A) were considerably expressed in the serum of lupus nephritis IV patients in comparison to the healthy control. However, only IL18 and IL6 were higher in class IV versus class III lupus nephritis. Importantly, the ratios of Th1/Th2 (IL-18/IL-4) and Th17/Th2 (IL-17A/IL-4) were significantly elevated in LN-IV when compared with LN-III, LN-V, and healthy controls. Consistently, the serum cytokines IL-18, IL-17A, and IFN-γ were markedly expressed in LN-IV patient glomeruli and interstitial tissue compared to other classes of LN by IHC. ROC further suggests that IL-18 was a potential marker for LN-IV. The data from our study suggests that the early detection and quantification of these cytokines may help in prediction of active form of LN-IV.

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“…Table ( 8) shows rates of response between males and females with no significant difference; however despite being non significant our male patients showed a higher response rate either CR or PR than females.…”

Section: Results:-mentioning

confidence: 59%

Management and Clinical Outcome of Systemic Lupus Erythematosus Patients; At Nephrology Unit , Zagazig University Hospitals: A One Year Study.

AmirM.ElOkely¹,

AdelA.M.Ghorab²,

MahmoudM.MagdyMahmoud³

et al. 2016

IJAR

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Clinicopathological and outcome analysis of adult lupus nephritis patients in China

Abstract: Clinicopathological characteristics, treatment responses and long-term outcomes differ remarkably in LN patients with different gender and pathological subtypes. New indicators of poor renal outcome were identified. Infections and TTP were the most common causes of death in LN patients.

Cited by 32 publications

References 25 publications

Development and validation of a prediction score system in lupus nephritis

Development and validation of a prediction score system in lupus nephritis

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Management and Clinical Outcome of Systemic Lupus Erythematosus Patients; At Nephrology Unit , Zagazig University Hospitals: A One Year Study.

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