Clinicopathological and prognostic significance of LINC00673 in human malignancy: a review and meta-analysis

Abstract

Background: We conducted this research to investigate the relationship between linc00673 expression and prognosis and clinicopathological parameters in human malignancies. Methods: The PubMed, Embase, WOS and CNKI databases were used to collect eligible research data before January 4, 2021. Meta-analysis was performed using Stata 12.0 software. Pooled ORs (odds ratios) or HRs (hazard ratios) and their 95% CIs were calculated to evaluate the association of linc00673 expression with survival outcomes and clinical parameters. Results: We finally included 17 articles and a total of 1539 cases for the meta-analysis. The results indicated that linc00673 was significantly correlated with T stage (P=0.006), tumour stage (P<0.001), lymph node metastasis (P<0.001), and distant metastasis ( P<0.001). In addition, the results suggested that elevated linc00673 expression predicted a poor overall survival time (P=0.034) and acted as an independent prognostic factor (P<0.001) for OS in patients with malignancy. Although potential evidence of publication bias was found in the studies on OS in relation to tumour stage in the multivariate analysis, the trim-and-fill analysis confirmed that the results remained stable. Conclusion: Overexpression of linc00673 was significantly correlated with shorter OS time in patients with malignant tumours. Moreover, the increased expression level of linc00673 was significantly correlated with T stage, tumour stage, lymph node metastasis, and distant metastasis. The results presented in this article revealed that linc00673 might be involved in the progression and invasion of malignancy and serve as a novel prognostic biomarker and potential therapeutic target for malignancy.

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

“…Long noncoding RNAs (lncRNAs) are a group of RNAs that could contribute to angiogenesis and cell proliferation in tumor cells ( Su S.-C. et al, 2018 ; Zhao et al, 2020 ; Su et al, 2021b ; Ding et al, 2021 ). Among this group, long intergenic noncoding RNA 00673 (LINC00673) is associated with several malignancies ( Zhu K. et al, 2021 ; Zhu Y. et al, 2021 ). In addition, LINC00673 SNPs can influence the expression of cancers such as oral cancer and gastric cancer ( Zhao et al, 2019 ; Su et al, 2021a ).…”