Clinicopathological and Prognostic Significance of Long Non-coding RNA MIAT in Human Cancers: A Review and Meta-Analysis

Abstract

Background: Although the treatment of cancer has made evident progress, its morbidity and mortality are still high. A tumor marker is a critical indicator for early cancer diagnosis, and timely cancer detection can efficiently help improve the prognosis of patients. Therefore, it is necessary to identify novel markers associated with cancer. LncRNA myocardial infarction associated transcript (MIAT) is a newly identified tumor marker, and in this study, we aimed to explore the relationship between MIAT and clinicopathological features and patient prognosis.Methods: We searched PubMed, Embase, Web of Science, and The Cochrane Library from inception to September 2020 to identify correlational studies. Then, we extracted valid data and used Stata software to make forest plots. We used the hazard ratio (HR) or odds ratio (OR) with 95% CI to evaluate the relationship between aberrant expression of MIAT and patients' prognosis and clinicopathological features.Results: The study included 21 studies, containing 2,048 patients. Meta-analysis showed that overexpression of lncRNA MIAT was associated with poor overall survival (OS) (HR = 1.60, 95% CI, 1.31–1.96, p < 0.001). In addition, high expression of MIAT could forecast tumor size (OR = 2.26, 95% CI 1.34–3.81, p = 0.002), distant metastasis (OR = 2.54, 95% CI 1.84–3.50, p < 0.001), TNM stage (OR = 2.38, 95% CI 1.36–4.18, p = 0.002), lymph node metastasis (OR = 2.59, 95% CI 1.25–5.36, p = 0.011), and the degree of differentiation (OR = 2.65, 95% CI 1.54–4.58, p < 0.001). However, other clinicopathological features, including age (OR = 1.07, 95% CI 0.87–1.32, p = 0.516), gender (OR = 0.95, 95% CI 0.77–1.19, p = 0.668), and histology (OR = 0.72, 95% CI 0.48–1.10, p = 0.128) were not significantly different from high expression of MIAT.Conclusions: Our study showed that overexpression of MIAT is related to poor overall survival and clinicopathological features. MIAT can be considered a novel tumor marker to help diagnose tumors earlier and improve patient prognosis.

FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis

“…Increasing evidence demonstrates that lncRNAs were aberrantly expressed in a variety of malignancies, act as oncogenes or tumor suppressors based on their expression levels, and play a role in cancer development. For example, lncRNAs, such as PANDAR (31), MIAT (32), and SNHG15 (33) have been shown to be aberrantly expressed in various tumors and interrelated with the prognosis of tumor patients. Together, these findings suggested that lncRNA could be a distinct cancer prognostic biomarker and therapeutic target.…”

Roles of Non-Coding RNAs in Primary Biliary Cholangitis

“…Studies on ncRNAs in human biology have gained much interest in the scientific world in recent years (Kapoor et al, 2021;Makkos et al, 2021;Wang et al, 2021). The role of ncRNAs in immune regulation, inflammation and autoimmunity can be of significant translational implication in medicine.…”

Noncoding RNome as Enabling Biomarkers for Precision Health

“…Multiple meta-analyses have also demonstrated the prognostic value of other ncRNAs such as lncRNAs, circRNAs and large intergenic noncoding RNA (lincRNA) in cancer patients. For example, expression of a lncRNAs, such as nuclear paraspeckle assembly transcript 1 (NEAT1) [ 155 ], myocardial infarction associated transcript (MIAT) [ 156 ], noncoding RNA activated by DNA damage (NORAD) [ 157 ] and growth arrest-specific 5 transcript (GAS5) [ 158 ], as well as expression of circRNA, such as, ciRS-7 [ 159 ] and lincRNA-regulator of reprogramming (lincRNA-ROR) [ 160 ], have been found to be associated with overall survival of cancer patients.…”