Clinicopathological characteristics and MYC status determine treatment outcome in plasmablastic lymphoma: a multi-center study of 76 consecutive patients

Witte, Hanno M; Hertel, N.; Merz, Hartmut; Bernd, Heinz‐Wolfram; Bernard, Veronica; Stölting, Stephanie; Bubnoff, Nikolas von; Feller, Alfred C.; Gebauer, Niklas

doi:10.1038/s41408-020-0327-0

Cited by 13 publications

(28 citation statements)

References 16 publications

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“…Our findings, and those of others regarding MYC gene rearrangements, indicate that the majority of HIV‐associated PBL tumours harbour MYC aberrations (increased MYC copy numbers and/or translocations) 5,30,34 . Accordingly, the scene is set for future therapeutic targeting of oncogenic MYC , either directly and/or indirectly 35 …”

Section: Discussionsupporting

confidence: 70%

“…Gene copy enumeration by CISH, for purposes of targeted oncological therapy of breast and lung carcinoma, has been validated 28,29 . Due to the limited available data regarding MYC gene copy status in PBL, 9,26,27,30 we opted to investigate MYC gene copy numbers within HIV‐associated PBL. We utilised dual‐colour MYC and CEN8 CISH as well as FISH which demonstrated increased MYC gene copy numbers in 43% of HIV PBLs.…”

Section: Discussionmentioning

confidence: 99%

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MYC status in HIV‐associated plasmablastic lymphoma: dual‐colour CISH, FISH and immunohistochemistry

et al. 2021

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Aims We utilised chromogenic and fluorescence in‐situ hybridisation (CISH and FISH) to evaluate MYC gene copy numbers and rearrangements within HIV‐associated plasmablastic lymphomas (PBLs). Thereafter, clinicopathological features were explored retrospectively. Methods and results Sixty‐seven (n = 67) patients were included and the HIV seropositive status was confirmed in 98% (63 of 64) with a median viral load of 55 587 (IQR 273 582) copies/ml and median CD4 count of 170 (IQR 249) cells/µl. The mean age was 41 ± 10.1 years and females comprised 54%. PBL was documented predominantly at extra‐oronasal topographic regions. Starry‐sky (SS) appearance was evident in 33% in association with monomorphic morphology (P‐value 0.02). c‐MYC protein was expressed in 81% and latent EBV infection was detected in 90%. EBER ISH‐positive status and MYC rearrangement occurred in 67% of HIV PBL. MYC aberrations included MYC rearrangement (70%), low‐level increase in MYC gene copy numbers (43%), concurrent MYC rearrangement and increased MYC gene copy numbers (49%) as well as low‐level chromosome 8 polysomy (6%). MYC aberrations in HIV PBLs were significantly associated with SS appearance (P ‐0.01), monomorphic morphology (P ‐ 0.03), c‐MYC protein expression ≥40% (P ‐ 0.03) and mortality (P ‐ 0.03). There was advanced stage (Ann Arbor III/IV) at presentation (77%) and the median overall survival for HIV PBL was 75 days (95% CI 14–136). Conclusion Majority of the HIV‐associated PBL tumours harbour MYC aberrations. Due to the persistently inferior survival outcome of HIV‐associated PBL in the era of antiviral treatment, targeted and/or intensified therapy of oncogenic MYC may need to be explored in future.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

MYC status in HIV‐associated plasmablastic lymphoma: dual‐colour CISH, FISH and immunohistochemistry

et al. 2021

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“…Most cases are found in advanced stages, usually being classified as Ann Arbor III and IV neoplasms, which negatively affects patient prognosis. 12,15,16 In most series, patients usually do not demonstrate B-symptoms, [17][18][19] but Witte et al (2020) 16 recently described these systemic manifes- of tumour cells. However, the true nature of this plasmacytic component may not be easily determined, as many of these cells may represent a reactive component rather than true neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

“…6 Miao et al (2019) 21 reported that the C-MYC translocation was significantly associated with HIV-positive patients; however, such association and the prognostic significance of this chromosomal abnormality remain to be fully validated. 6,15,16,20 A gene expression profile study Adjuvant radiotherapy and bone marrow transplantation have also been described in some studies. 13,[23][24][25] Although complete remission can be obtained in rare cases, survival rates are generally short, ranging from 6 to 12 months.…”

Section: Discussionmentioning

confidence: 99%

Oral plasmablastic lymphoma: A clinicopathological study of 113 cases

Fonseca

Robinson

Heerden

et al. 2021

J Oral Pathology Medicine

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Plasmablastic lymphoma (PBL) is defined as an aggressive lymphoid neoplasm comprising of a diffuse proliferation of immunoblasts and plasmablasts that are typically negative or only focally positive for the mature B-cell markers CD20/PAX5. The neoplastic cells may contain variable proportions of plasmacytic differentiation, demonstrating positivity for plasma cell markers such as CD38, CD138, VS38c and MUM1. 1 PBL was first described in 1997 and has since been strongly associated with HIV-positive patients, particularly in

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“…PL'nin ortalama tanı yaşı ise 65,67 idi. Witte ve ark yaptığı çok merkezli çalışmada PL'da ortanca tanı yaşı 63 olarak bildirilmiştir (12). NHL gelişiminde immunsupresyon, çevresel etkenler yanı sıra enfeksiyöz etkenler de rol oynamaktadır (1,7,11).…”

Section: Introductionunclassified

Ege Üniversitesi Hastanesi veri tabanında kayıtlı erişkin Hodgkin dışı lenfoma olgularının epidemiyolojik özelliklerinin retrospektif olarak değerlendirilmesi

et al. 2020

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Clinicopathological characteristics and MYC status determine treatment outcome in plasmablastic lymphoma: a multi-center study of 76 consecutive patients

Cited by 13 publications

References 16 publications

MYC status in HIV‐associated plasmablastic lymphoma: dual‐colour CISH, FISH and immunohistochemistry

MYC status in HIV‐associated plasmablastic lymphoma: dual‐colour CISH, FISH and immunohistochemistry

Oral plasmablastic lymphoma: A clinicopathological study of 113 cases

Ege Üniversitesi Hastanesi veri tabanında kayıtlı erişkin Hodgkin dışı lenfoma olgularının epidemiyolojik özelliklerinin retrospektif olarak değerlendirilmesi

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