Clinicopathological characteristics and outcomes in men with mesothelioma of the tunica vaginalis testis: Analysis of published case series data

Grogg, Josias Bastian; Fronzaroli, Jordi Nicola; Bode, Peter-Karl; Oliveira, Pedro; Lorch, Anja; Beyer, Jörg; Eberli, Daniel; Sangar, Vijay; Hermanns, Thomas; Clarke, Noel W.; Fankhauser, Christian Daniel

doi:10.1016/s2666-1683(20)36274-1

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“…The study also has insufficient statistical power to comment on cancer-related outcome. Hemiscrotectomy with or without en bloc orchidectomy represents an important surgical procedure for several indications including sarcomas of the inguinal cord, 6 – 8 mesotheliomas of the tunica vaginalis testis, 9 locally advanced or recurring germ cell tumours 10 – 12 as well as for basal or squamous cell carcinoma, melanoma or extramammary Paget’s disease of the scrotum. 13 However, stringent indication for hemiscrotectomy with or without en bloc orchidectomy instead of less radical options including wide local excision or orchidectomy only is not defined in the current literature, but our group is working on systematic reviews and meta-analysis with the aim to answer this question.…”

Section: Discussionmentioning

confidence: 99%

Radical Hemiscrotectomy and En Bloc Orchidectomy: Surgical Technique and Perioperative and Oncologic Outcomes of a Supra-Regional UK Referral Centre

et al. 2021

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Background and Purpose Hemiscrotectomy with en bloc orchidectomy represents a radical primary, completion, or salvage option in men with inguinoscrotal cancers. We describe our surgical technique and peri-operative and oncological outcomes. Patients and Methods Retrospective cohort study of 16 men treated at a supra-regional referral centre with open radical hemiscrotectomy with or without en bloc orchidectomy between 2010 and 2020. Peri-operative and survival outcomes were analysed. Results Radical hemiscrotectomy with or without en bloc orchidectomy was performed on 16 patients comprising 7 well-differentiated liposarcomas, 4 dedifferentiated liposarcomas, 2 leiomyosarcomas, 1 mesothelioma, 1 rhabdomyosarcoma and 1 mammary type myofibroblastoma. Primary hemiscrotectomy was performed in four, completion hemiscrotectomy in nine and salvage hemiscrotectomy in three. The median hospital stay was 2 days [interquartile range (IQR) 2–4]. Four patients (25%) had post-operative complications including wound infection or haematoma. During a median follow-up of 18 months (IQR 2–66), one patient (6%) died following a recurrence in the pelvis and retroperitoneum. Discussion and Conclusions If careful dissection is performed, radical hemiscrotectomy and en bloc orchidectomy is a radical but safe procedure with a short hospital stay. Haematoma and infection represent the main complications, and within limited follow-up most men showed no recurrence.

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