Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung

Yang, Zhi; Wang, Zitong; Duan, Yong; Xu, Shaofa

doi:10.1111/1759-7714.12377

Cited by 12 publications

(31 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 10-year survival rate was 93% for the N0 group and declined to < 30% for the N1 group and N2 group [31]. Another study showed that 50% of the AC tumors had a tumor diameter of > 3 cm [39].…”

Section: Tumor Diameter and Locationmentioning

confidence: 99%

“…Several studies reported on disease free survival (DFS), but the majority reported overall survival (OS) ( Tables 1 & 2 ). Five and ten year OS for TC ranged from 82 to 100% and 60-100%, and for AC 50-95% and 38-75% respectively [13,17,18,20,[22][23][24][25][26][27][28][29][30][31]34,35,38,39,[41][42][43][44][46][47][48][49][51][52][53]. Five-and ten year DFS for TC ranged from 83 to 100% and 73-95% for TC, and 44-87% and 24-71% in AC, respectively [3,16,18,20,30,[49][50][51]53].…”

Section: Overall Survival and Disease Free Survivalmentioning

confidence: 99%

“…Complications were commonly reported, with an overall complication rate for surgery and EBT ranging from 1 to 63% and 0-30%, respectively (Table 4). However, no clear definition for complications was defined, and the number of patients included varied from 11 to > 250 patients [3][4][5][6][7][8][9][10][11][12][13][14]18,20,21,[23][24][25][27][28][29][30][31][32][33][35][36][37][38][39]41,42,44,46,[48][49][50]. Table 4 presents all documented complications.…”

Section: Complicationsmentioning

confidence: 99%

“…Tumor location [28,45] and diameter [12,39,45,54] are important factors to predict successful treatment. Seventy percent of all carcinoids are centrally located [29,31].…”

Section: Tumor Diameter and Locationmentioning

confidence: 99%

“…One study described that purely intraluminal growing carcinoid tumors of ≤2 cm are candidates for successful EBT [12]. Two studies described a diameter of > 3 cm is related to a worse outcome and higher N stage [31,39]. A median tumor diameter of 22.5 mm was seen in the N0 group compared to a tumor diameter of 33.5 mm and 38 mm in the N1 and N2 group.…”

Section: Tumor Diameter and Locationmentioning

confidence: 99%

See 4 more Smart Citations

Endobronchial and surgical treatment of pulmonary carcinoid tumors: A systematic literature review

et al. 2019

View full text Add to dashboard Cite

A B S T R A C TThe treatment of pulmonary carcinoid has changed over the last decades. Although surgical resection is still the gold standard, minimally invasive endobronchial procedures have emerged as a parenchyma sparing alternative for tumors located in the central airways. This review was performed to identify the optimal treatment strategy for pulmonary carcinoid, with a particular focus on the feasibility and outcome of parenchyma sparing techniques versus surgical resection. A systematic review of the literature was carried out using MEDLINE, Embase and the Cochrane databases, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Two separate searches of publications in endobronchial and surgical treatment in patients with pulmonary carcinoid, were performed. Outcomes were overall survival, disease free survival, recurrence rate, complications, quality of life, and healthcare costs. Combining the two main searches for endobronchial therapy and surgical therapy yielded 3111 records. Finally, 43 studies concerning surgical treatment and 9 studies related to endobronchial treatment for pulmonary carcinoid were included. Assessment of included studies showed that lymph node involvement, histological grade, tumor location and tumor diameter were identified as poor prognostic factors and seem to be important for patients with pulmonary carcinoid. For patients with a more favorable prognosis, tumor location and tumor diameter are important factors that can help decide on the optimal treatment strategy. Centrally located small intraluminal pulmonary carcinoids, without signs of metastasis can be treated with minimally invasive alternatives such as endobronchial treatment or parenchyma sparing surgical resection. Patients with parenchyma sparing resections should be followed with long term follow up to exclude recurrence of disease. In a multidisciplinary setting, it should be determined whether individual patients are eligible for parenchyma sparing procedures or anatomical resection. Overall evidence is of low quality and future studies should focus on prospective trials in the treatment of pulmonary carcinoid.

show abstract

Section: Tumor Diameter and Locationmentioning

confidence: 99%

Section: Overall Survival and Disease Free Survivalmentioning

confidence: 99%

Section: Complicationsmentioning

confidence: 99%

“…Tumor location [28,45] and diameter [12,39,45,54] are important factors to predict successful treatment. Seventy percent of all carcinoids are centrally located [29,31].…”

Section: Tumor Diameter and Locationmentioning

confidence: 99%

Section: Tumor Diameter and Locationmentioning

confidence: 99%

See 3 more Smart Citations

Endobronchial and surgical treatment of pulmonary carcinoid tumors: A systematic literature review

et al. 2019

View full text Add to dashboard Cite

show abstract

Prognostic nomogram and epidemiological analysis for lung atypical carcinoid: A SEER database and external validation study

Yi,

He,

Qian

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

PurposeOur study aims to delineate the epidemiological distribution of pulmonary carcinoids, including atypical carcinoid (AC) and typical carcinoid (TC), identify independent prognostic factors, develop an integrative nomogram and examine the effects of various surgical modalities on atypical carcinoid‐specific survival (ACSS).MethodsJoinpoint regression model and age‐group distribution diagram were applied to determine the epidemiological trend of the pulmonary carcinoids. Univariate and least absolute shrinkage and selection operator (LASSO)‐based Cox regression models were used to identify independent factors, and a nomogram and web‐based predictor were developed to evaluate prognosis of AC patients individually. We performed Kaplan–Meier survival analyses to compare the scope of various surgical interventions, with and without G‐computation adjustment, utilising restricted mean survival time (RMST) to assess survival disparities.ResultsA total of 1132 patients were recruited from the Surveillance, Epidemiology, and End Results database (SEER) and a separate medical centre in China. The mean age of AC patients was 63.4 years and a smoking history was identified in 79.8% of AC patients. Joinpoint analysis shows rising annual rates of new AC and carcinoid cases among lung cancers. Both the proportion of pulmonary TC and AC within the total lung cancer population exhibits an L‐shaped trend across successive age groups. The nomogram predicted 1, 3 and 5 years of AC with excellent accuracy and discrimination. Kaplan–Meier survival analyses, conducted both pre‐ and post‐adjustment, demonstrated that sublobar resection's survival outcomes were not inferior to those of lobectomy in patients with stage I‐II and stage III disease.ConclusionThis study is the first to reveal epidemiological trends in pulmonary carcinoids over the past decade and across various age cohorts. For patients with early‐stage AC, sublobar resection may be a viable surgical recommendation. The established nomogram and web‐based calculator demonstrated decent accuracy and practicality.

show abstract

Long-term survival and recurrence after resection of bronchopulmonary carcinoids: A single-center cohort study of 236 patients

et al. 2021

View full text Add to dashboard Cite

The aim of this study was to determine overall survival and recurrence-free survival after resection of bronchopulmonary carcinoids by means of predominantly minimally invasive surgery and lung-sparing resections. In addition, we aimed to identify prognostic factors for overall survival. Materials and methods: Retrospective review of consecutive patients operated for bronchopulmonary carcinoids between January 2009 and October 2020 identified from a prospectively collected database. Results: A total of 236 patients representing 240 cases of bronchopulmonary carcinoids were included. Of these, 212 (88.3 %) were typical carcinoids, while 28 (11.7 %) were atypical carcinoids. A Video-Assisted Thoracoscopic Surgery (VATS) approach was used in 75 % of cases. There was no 30-day mortality. The median followup was 5.6 years for overall survival and 4.7 years for recurrence-free survival. 5-and 10-year overall survival rates were 89 % and 71 %, while 5-and 10-year recurrence-free survival rates were 84 % and 71 %. Patients with atypical carcinoids had significantly reduced overall survival and recurrence-free survival rates (HR 3.4; 95 % CI 1.5-7.6; p = 0.003 and HR 5.4; 95 % CI 2.6-11.4; p < 0.001). Independent predictors of overall survival included atypical carcinoid (HR 2.7; 95 % CI 1.2-6.0; p = 0.018) and age > 60 years (HR 2.9; 95 % CI 1.2-7.3; p = 0.021). Conclusion: Surgery for bronchopulmonary carcinoids by means of predominantly VATS and lung-sparing resections provides favorable long-term survival. Atypical carcinoids and age > 60 years are independent predictors of poor overall survival.

show abstract

Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung

Cited by 12 publications

References 22 publications

Endobronchial and surgical treatment of pulmonary carcinoid tumors: A systematic literature review

Endobronchial and surgical treatment of pulmonary carcinoid tumors: A systematic literature review

Prognostic nomogram and epidemiological analysis for lung atypical carcinoid: A SEER database and external validation study

Long-term survival and recurrence after resection of bronchopulmonary carcinoids: A single-center cohort study of 236 patients

Contact Info

Product

Resources

About