Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms

Han, Deng; Li, Yuanliang; Zhou, Zhiwei; Yin, Fei; Chen, Jie; Liu, Fang; Shi, Yanfen; Wang, Wei; Lei, Yu; Xu, Jianming; Yang, Runxiang; Tian, Chao; Luo, Jie; Tan, Huangying

doi:10.3748/wjg.v27.i21.2895

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…7 The clinical manifestations engendered by cancer metastasis were abdominal distension and belly pain. 8 A previous study has reported that the prognosis of GNEC was worse than that of gastric adenocarcinoma. 9 Tumor size, stage, location, and treatment were significantly associated with the prognosis of GNEC patients.…”

Section: Introductionmentioning

confidence: 98%

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The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

Chu

et al. 2021

Technol Cancer Res Treat

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Objectives: Gastric neuroendocrine carcinoma (GNEC) is a class of rare histological subtypes in gastric cancer (GC). This retrospective case-control study aimed to explore the clinicopathological features and overall survival (OS) of patients with GNEC. Methods: A large population of GNEC and intestinal-type GC (IGC) patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The 1:1 propensity score matching (PSM) analysis was initiated to adjust the confounders between GNEC and IGC cohorts. Kaplan-Meier (KM) plots with log-rank tests were used to compare the survival differences in GNEC versus IGC. Additionally, Cox proportional hazard regression models were adopted to characterize the prognostic factors relevant to OS of the GNEC patients. Results: An entity of 4596 patients were collected, including 3943 (85.8%) IGC patients and 653 (14.2%) GNEC patients. The PSM analysis well-balanced all confounders in GNEC versus IGC (all P > .05). The KM plots showed that GNEC had significantly superior OS to IGC both before and after PSM analysis. Before PSM, the median OS was 52 (33.6-70.4) months in GNEC versus 32 (29.3-34.7) months in IGC ( P = .0015). After PSM, the median OS was 26 (18.3-33.7) months in GNEC versus 21 (17.7-24.3) months in IGC ( P = .0039). Stratified analysis indicated that GNEC had superior survivals to IGC in early stage patients and those who received surgery. In Cox regression analysis, age ≥ 60, tumor size > 50 mm, stage II-IV, T2, and N3 were independent risk factors for the GNEC patients (hazard ratio [HR]>1, P < .05). By contrast, year 2010 to 2015, female, and surgery were independent protective factors for these patients (HR < 1, P < .05). Conclusions: GNEC has unique clinicopathological features quite different from IGC and may have a superior survival to IGC in early stage patients. The prognostic factors identified here may assist the clinicians to more individually treat these patients.

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Section: Introductionmentioning

confidence: 98%

“…9 Tumor size, stage, location, and treatment were significantly associated with the prognosis of GNEC patients. 8 However, the survival differences between GNEC and IGC have not been clarified yet. Understanding these differences is important for prognosis evaluation and tailored treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

Chu

et al. 2021

Technol Cancer Res Treat

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“…Because LCNEC can arise from adenocarcinoma, it usually contains an adenocarcinoma component and thus has a high risk of being misdiagnosed as adenocarcinoma, which can hinder the pathological diagnosis. 22 The pathology in the current patient accordingly revealed an adenocarcinoma component, highlighting the need to understand the morphological and pathological characteristics of GLCNEC. Our patient had a solitary, metachronous (8 months after gastrectomy) tumor less than 4 cm in diameter and underwent successful radical resection.…”

Section: Discussionmentioning

confidence: 98%

Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

et al. 2023

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Surgical resection is rarely employed for the treatment of metastatic gastric cancer, especially in patients with adrenal metastases, which usually indicate advanced systemic dissemination. Few published case reports have thus described the use of adrenalectomy for adrenal metastases from gastric cancer. In addition, most primary gastric malignancies are gastric adenocarcinomas, and gastric large cell neuroendocrine carcinoma (GLCNEC) is less common and has a poor prognosis. We report the case of a 71-year-old man who was diagnosed with solitary adrenal metastases 10 months after radical resection for GLCNEC and who was treated by adrenalectomy. He was followed-up for 9 months after adrenalectomy, with no further evidence of disease at his last follow-up examination. This case indicates that elective surgical resection may be feasible, even in rare cases of GLCNEC metastases to the adrenal glands, provided that the patient meets certain criteria, including solitary, metachronous tumors less than 4 cm.

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“…Early G-NENs have weak invasiveness, a low malignancy rate and a good prognosis, with an OS as high as 100% in 3 years [39] . Hu et al [40] showed that for patients with G-NENs, the MST exceeded 150 months, and the total OS was 81.1% in 5 years.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of gastric malignancies based on the SEER database

Han

Liu

Zhang

et al. 2023

Preprint

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Introduction: Gastric malignancies are common worldwide, with a high incidence rate and mortality. Relevant studies are needed to further demonstrate the harmfulness of gastric malignancies to improve the awareness of its prevention. Methods: The SEER database was used to obtain the clinical data of 122793 patients diagnosed with gastric malignancies from 2000 to 2019. Along with performing univariate and multivariate analyses, the associated survival rates of each variable were analyzed using SPSS software. Columnar line graph prediction models were developed and validated using R software. Results: In total, 122793 gastric malignancy patients were included in this study, including 74303 males(60.51%) and 48490 females(39.49%). Most patients were aged 60-74 years old: 45603 patients(37.14%). The follow-up time was 0-239 months, the median follow-up time was 11 months, and 91869 patients(74.82%) died. Gastric adenocarcinoma was the main pathological type: 96259 patients(78.39%). The main disease site was the cardia of the stomach: 34019 patients(27.70%); Most patients lived in cities: 109706 patients(89.34%). Univariate and multivariate analysis showed that gender, age, tumor size, tumor location, AJCC stage, pathological type, rural/urban, and treatment were independent risk factors for prognosis(P<0.05). The C-index of the nomogram prognostic model was 0.763 ± 0.002, and the areas under the ROC curve of the 1-year, 3-year and 5-year survival rates were 0.76, 0.79 and 0.79,respectively. The calibration curve showed that the predicted survival rate of the nomogram was in good agreement with the observed survival rate. Conclusion: The prognosis of tumors located in the greater curvature of the stomach is relatively good. The patient’s city level is proportional to the prognosis. The prognosis of gastric stromal tumors and gastric neuroendocrine neoplasms is significantly better than that of the other pathological types. The patients who reach the surgical indication should have surgery as early as possible to prolong the survival time.

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Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms

Cited by 7 publications

References 27 publications

The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

The Clinicopathological Features and Overall Survival of Patients With Gastric Neuroendocrine Carcinoma

Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

Clinicopathological characteristics and prognosis of gastric malignancies based on the SEER database

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