Clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as ground glass opacity nodule

Moon, Youngkyu; Sung, Sook Whan; Lee, Kyo Young; Park, Jae Kil

doi:10.21037/jtd.2016.08.46

Cited by 29 publications

(23 citation statements)

References 28 publications

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“…which revealed the most powerful factor to predict IA was the diameter of the solid component . Moreover, the patients with solid‐predominant nodules were at a greater risk of recurrence compared to those with GGO‐predominant nodules . Therefore, part‐solid GGO nodules should be regarded as having a higher risk of invasiveness and surgical intervention should be considered.…”

Section: Discussionsupporting

confidence: 56%

“…20 Moreover, the patients with solid-predominant nodules were at a greater risk of recurrence compared to those with GGOpredominant nodules. 21 Therefore, part-solid GGO nodules should be regarded as having a higher risk of invasiveness and surgical intervention should be considered. Tumor size of the GGO nodule was another critical risk factor of potential malignancy.…”

Section: Discussionmentioning

confidence: 99%

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Invasiveness and surgical timing evaluation by clinical features of ground‐glass opacity nodules in lung cancers

et al. 2019

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Background The early stages of lung cancer with ground‐glass opacity (GGO) pattern are detectable. However, it remains a challenge for physicians how best to treat GGO nodules as invasive tumors are occasionally found, even in pure GGO nodules. This study identified the invasiveness by the clinical features of the GGO nodules. Methods A retrospective review of patients with resected GGO nodules from August 2015 to February 2019 was performed. A total of 92 patients were enrolled and gender, age, tumor location, operation times, tumor size, histopathologic and radiological findings were analyzed. Results In this study, the sequential of GGO nodules invasiveness was significantly related to the tumor size and solid component. After regrouping the population into preinvasive and invasive groups, the invasiveness was significantly related to tumor size, solid component, tumor volume and maximal computed tomography (CT) value. Conclusions The invasiveness is difficult to evaluate according to the CT features only when the GGO nodules are less than 2 cm and consolidation/tumor ratio (C/T ratio) are less than 0.25. Tumor size and solid component are significant factors for predicting invasiveness. Part‐solid GGO nodules with a diameter greater than 1 cm require surgical consideration due to their high risk of invasiveness.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Invasiveness and surgical timing evaluation by clinical features of ground‐glass opacity nodules in lung cancers

et al. 2019

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“…Malignant nodules presenting as GGNs are regarded as low-grade malignancies with three subtypes: adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic adenocarcinoma. 6 This review focuses on the perioperative management and surgical treatment of GGNs based on different categories.…”

Section: Introductionmentioning

confidence: 99%

New horizons in surgical treatment of ground-glass nodules of the lung: experience and controversies

Chen¹,

Dai²,

Kadeer³

et al. 2018

TCRM

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Ground-glass nodule (GGN) is defined as a nodular shadow with ground-glass opacity that is generally associated with the early-stage lung adenocarcinoma. Nowadays, GGNs of the lung are increasingly detected with thin-section computed tomography scan. GGNs are categorized as pure GGNs and mixed GGNs according to the images from a high-resolution computed tomography. Meanwhile, it is routine to divide GGNs into different categories according to the number, solitary, or multiple, the management of which there is very different. A great number of studies have been conducted to analyze the different characteristics of GGNs in various aspects ranging from radiology, pathology, and surgery to molecular biology. However, plenty of problems still remain unsolved, ranging from the preoperative localization to intraoperative surgical resection procedure, the lymphadenectomy, and sampling of lymph nodes, as well as the accuracy of frozen sections. There has been a large volume of updated published information summarizing recently emerging and rapidly progressing aspects of surgical treatment of solitary and multiple GGNs with the unsolved problems mentioned above. However, there have been few specific reviews of surgical treatment of GGNs so far. This review presents a timely outline of advances in relevant experience and controversies of GGNs for a better understanding of this kind of lesion.

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“…In general, the radiological features of central ADC in our study appeared to be aggressive, which might indicate poor prognosis. Studies have proven the relationship between prognosis and the features of ADCs on CT imaging, including the percentage of ground-glass opacity, 10 , 34 , 35 pleural attachment, 36 , 37 lymphadenopathy, 36 , 37 lymphovascular invasion 19 and so on. Most of these studies did not distinguish central from peripheral ADCs.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiological characteristics of central pulmonary adenocarcinoma: a comparison with central squamous cell carcinoma and small cell lung cancer and the impact on treatment response

Wang¹,

Li²,

Huang³

et al. 2018

OTT

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PurposeThe proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological characteristics of central ADCs with those of small cell lung cancers (SCLCs) and squamous cell carcinomas (SQCCs) and investigated the impact of these characteristics on patients’ treatment response.Patients and methodsThe medical records of 302 consecutive patients with central lung cancer from July 2014 to September 2016 were retrospectively reviewed. There were 99 patients with ADC, 95 with SQCC and 108 with SCLC. Computed tomography images were interpreted by two radiologists. Treatment response was determined by Response Evaluation Criteria In Solid Tumors 1.1.ResultsUnivariate analyses found that younger age, female sex, no history of smoking, higher levels of carcinoembryonic antigen (CEA), contralateral hilum lymphadenopathy, contralateral lung metastasis, pleural nodules and pleural metastasis to the interlobular fissure were significantly correlated with central ADC. Multivariate logistic regression analyses revealed that compared with central SQCC, female sex, younger age, no history of smoking, higher levels of CEA and contralateral hilum lymphadenopathy were the significantly independent indicators of central pulmonary ADC. Furthermore, compared with central SCLC, younger age, higher levels of CEA and cytokeratin 19 fragment (Cyfra21-1), lower levels of neuron-specific enolase, pleural nodules and lack of vascular involvement were significantly associated with central ADC. In 85 central ADC patients who received first-line platinum-based chemotherapy, both univariate and multivariate logistic regression analyses revealed that pulmonary emphysema had a negative correlation with treatment response (odds ratio=8.04, p=0.02).ConclusionOur study revealed that central pulmonary ADCs exhibited more aggressive clinical and radiological characteristics. Pulmonary emphysema was an independent and negative indicator for treatment response of central ADC.

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Clinicopathological characteristics and prognosis of non-lepidic invasive adenocarcinoma presenting as ground glass opacity nodule

Cited by 29 publications

References 28 publications

Invasiveness and surgical timing evaluation by clinical features of ground‐glass opacity nodules in lung cancers

Invasiveness and surgical timing evaluation by clinical features of ground‐glass opacity nodules in lung cancers

New horizons in surgical treatment of ground-glass nodules of the lung: experience and controversies

Clinical and radiological characteristics of central pulmonary adenocarcinoma: a comparison with central squamous cell carcinoma and small cell lung cancer and the impact on treatment response

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