Clinicopathological characteristics and prognostic risk factors of cervical cancer patients aged ≤35 years old

Abstract

We aimed to explore the clinicopathological characteristics and prognostic risk factors of cervical cancer in patients aged ≤35 years. A total of 256 cervical cancer patients treated at Anhui Medical University Affiliated Maternity and Child Health Hospital and The First Affiliated Hospital of Anhui Medical University from January 2016 to October 2018 were divided into ≤35-year-old (n = 136) and >35-year-old (n = 120) groups. Their clinicopathological characteristics and 3-year cumulative disease-free survival (DFS) and overall survival (OS) rates were compared. The factors influencing the 3-year cumulative DFS rate of patients in the ≤35-year-old group were analyzed using univariate and multivariate Cox regression models. The human papillomavirus (HPV) infection rate, incidence rate of contact vaginal bleeding, depth of cervical interstitial infiltration, and incidence rates of parametrial metastasis and vascular infiltration were all significantly higher in the ≤35-year-old group than in the >35-year-old group. The 3-year cumulative DFS rates of all patients and those with HPV infection and contact vaginal bleeding were significantly lower in the ≤35-year-old group than in the >35-year-old group (69.12% vs. 77.50%, 68.29% vs. 80.85%, and 66.04% vs. 81.48%) (log-rank χ2 = 7.429, 4.339, and 4.276, P < .05). Depth of cervical interstitial infiltration >4 mm, parametrial metastasis, lymph node metastasis, and vascular infiltration were independent risk factors for the prognosis of cervical cancer patients aged ≤35 years (P < .05). Cervical cancer aged ≤35 years have a worse postoperative prognosis than those aged >35 years, which is affected by the depth of cervical interstitial infiltration >4 mm, parametrial metastasis, lymph node metastasis, and vascular infiltration. Therefore, it is necessary to identify more effective treatment methods for young patients with cervical cancer to improve the therapeutic effect and reduce the risk of recurrence and metastasis.

Prognostic Analysis of Local Advanced Cervical Cancer After Neoadjuvant Chemotherapy

“…Many studies analyzed prognostic factors, suggesting that for patients receiving NACT-RS, age, the number of lymph node metastases, focal diameter, LVSI, and disease stage are all prognostic factors [15][16][17][18]. In this study, the patients' tumor stage, tumor diameter, SCC level, imaging lymph node status, parastatal involvement, pathological lymph node metastasis status, LVSI and deep cervical interstitial infiltration were included in Cox risk regression, and the results showed that parastatal infiltration and LVSI were risk factors affecting 2-year PFS.…”

A Surgery-based Comprehensive Treatment Improved Prognosis in Patients with Stage IIIC Cervical Squamous Carcinoma: A Single Center Retrospective Study

“…Intermediate-risk factors include LVSI (+), deep stromal invasion, and larger primary tumors 19 . Previous studies have demonstrated that all of these risk factors are prognostically associated with lymph node-positive cervical cancers [20][21][22][23] . Based on these findings, the addition of adjuvant therapy should be recommended.…”