Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population‐based study

Liu, Yang; Sun, Hefen; Zhao, Yupei; Chen, Min‐Te; Zhang, Nong; Jin, Wei

doi:10.1002/cam4.1244

Cited by 13 publications

(11 citation statements)

References 14 publications

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“…In our present investigation, we found that the proportion of male patients with negative ER, negative PR and radiotherapy were lower than the reported proportion of breast cancer in female cases (26, 27), and MC patients had a shorter median follow-up time than FBC patients (28). Additionally, we identified five risk factors that have an impact on the male breast cancer-specific survival (MBCCS).…”

Section: Discussioncontrasting

confidence: 63%

Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer

et al. 2019

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Male breast cancer (MBC) is rare, and most patients are diagnosed at an advanced stage. We aimed to develop a reliable nomogram to predict breast cancer-specific survival (BCSS) for MBC patients, thus helping clinical diagnosis and treatment. Based on data from the Surveillance, Epidemiology, and End Results (SEER) database, 2,451 patients diagnosed with MBC from 2010 to 2015 were selected for this study. They were randomly assigned to either a training cohort ( n = 1715) or a validation cohort ( n = 736). The Multivariate Cox proportional hazards regression analysis was used to determine the independent prognostic factors, which were then utilized to build a nomogram for predicting 3- and 5-year BCSS. The discrimination and calibration of the new model was evaluated using the Concordance index (C-index) and calibration curves, while its accuracy and benefits were assessed by comparing it to the traditional AJCC staging system using the net reclassification improvement (NRI), the integrated discrimination improvement (IDI), and the decision curve analysis (DCA). Multivariate models revealed that age, AJCC stage, ER status, PR status, and surgery all showed a significant association with BCSS. A nomogram based on these variables was constructed to predict survival in MBC patients. Compared to the AJCC stage, the C-index (training group: 0.840 vs. 0.775, validation group: 0.818 vs. 0.768), the areas under the receiver operating characteristic curve of the training set (3-year AUC: 0.852 vs. 0.778, 5-year AUC: 0.841 vs. 0.774) and the validation set (3-year AUC: 0.778 vs. 0.752, 5-year AUC: 0.852 vs. 0.794), and the calibration plots of this model all exhibited better performance. Additionally, the NRI and IDI confirmed that the nomogram was a great prognosis tool. Finally, the 3- and 5-year DCA curves yielded larger net benefits than the traditional AJCC stage. In conclusion, we have successfully established an effective nomogram to predict BCSS in MBC patients, which can assist clinicians in determining the appropriate therapy strategies for individual male patients.

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Section: Discussioncontrasting

confidence: 63%

Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer

et al. 2019

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“…Previous reports have demonstrated that the prognosis of invasive PLC is significantly worse than that of invasive carcinoma of NST [6,7,27,28]. In contrast, another report has illustrated that PLC is not a prognostic factor compared with invasive carcinoma of NST via multivariate analysis [29]. In the present study, only five patients with PLC died of the disease, and it is unlikely that patients with PLC have worse prognosis than those with other types of breast cancer.…”

Section: Plos Onecontrasting

confidence: 64%

Triple-negative pleomorphic lobular carcinoma and expression of androgen receptor: Personal case series and review of the literature

Taniguchi

Takada²,

Omori

et al. 2020

PLoS ONE

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Pleomorphic lobular carcinoma (PLC) is a histological variant of invasive lobular carcinoma (ILC) and is associated with worse prognosis than classical ILC. It exhibits a greater degree of cellular atypia and pleomorphism and is occasionally accompanied with apocrine morphology. We investigated the immunohistochemical characteristics of samples from 31 Japanese patients with PLC to elucidate the clinicopathological characteristics of PLC including androgen receptor (AR) immunoreactivity. The surrogate molecular subtypes were luminal Alike , luminal B-like, luminal B-like/HER2, HER2-type, and triple-negative in 5, 4, 3, 5, and 14 cases, respectively. AR was positive in 92.8% (13/14) of the triple-negative PLC cases and 100% (10/10) of the non-triple-negative PLC cases. Disease-specific survival was worse in patients with histological grade 3 PLCs than in those with histological grade 2 PLCs (p = 0.007). However, there was no significant difference in the progression-free survival between the two groups (p = 0.152). No other clinicopathological characteristics were associated with prognosis. These results reveal that PLC exhibits various surrogate molecular subtypes and that the triple-negative subtype frequently expresses AR. The observed molecular apocrine differentiation implicates that triple-negative PLC can be categorized into the luminal AR subtype. Furthermore, AR-targeted therapy might be useful for patients with triple-negative PLC.

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“…Nevertheless, the lobular subtype of breast cancer was found to be less aggressive than other types of breast cancer in accordance with previous reports. 44 …”

Section: Discussionmentioning

confidence: 99%

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

Al-Asadi

Al-Mayah²

2020

Oman Med J

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Objectives We sought to determine the overall observed three-year survival rate of women with breast cancer in Basrah, Iraq, and investigate the associated factors. Methods Data was collected retrospectively from the Oncology Center registry in Basrah, all newly diagnosed women with breast cancer between 1 January 2013 and 31 December 2014 were included and followed-up until 31 December 2017. We used the Kaplan-Meier method to estimate the overall survival rates. Cox regression analysis was used to investigate the association between survival and prognostic factors. Results A total of 605 women who were diagnosed with breast cancer during 2013– 2014 were included in the study, 44.1% had advanced tumor stages (stage III and IV). The overall observed three-year survival rate was 83.3%. Cox regression analysis showed that late stage (stage IV vs. stage I hazard ratio (HR) = 4.65; 95% confidence interval (CI): 3.28–7.81) and grade (poorly vs. well differentiated HR = 4.10; 95% CI: 3.01–6.82) were significantly associated with poor survival. Conclusions The overall observed survival rate of women with breast cancer in Basrah was comparable to that reported for developing countries, but it is poorer than that of developed countries. Advanced stage and poorly differentiated tumors were significant predictors of poor survival.

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Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population‐based study

Cited by 13 publications

References 14 publications

Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer

Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer

Triple-negative pleomorphic lobular carcinoma and expression of androgen receptor: Personal case series and review of the literature

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

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