Clinicopathological characteristics of desmoplastic ameloblastoma: A systematic review

Sarode, Gargi S; Sarode, Sachin C.; Reddy, Mamatha Gs; Unadkat, H.V.; Mushtaq, Shazia; Deshmukh, Revati; Choudhary, Shakira; Gupta, Nitin; Ganjre, Anjali P; Patil, Shankargouda

doi:10.1111/jicd.12282

Cited by 7 publications

(8 citation statements)

References 69 publications

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“…The results of this study showed that the recurrence rates was much lower for patients who received aggressive treatment than for patients who received conservative treatment. This finding can guide the management of treatment approaches and offer prognostic information ( 34 ). Moreover, in this study, multicystic ameloblastomas presented a significantly higher recurrence rate compared with solid and unicystic ameloblastomas.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Rates of Intraosseous Ameloblastoma Cases With Conservative or Aggressive Treatment: A Systematic Review and Meta-Analysis

et al. 2021

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ObjectiveThis study aimed to systematically investigate and compare the post-treatment recurrence of intraosseous ameloblastoma in patients treated with conservative or aggressive approaches.MethodsSystemic searches of PubMed, Medline, Cochrane Library, and Embase databases from inception to October 28, 2020, were conducted. Studies that aimed to evaluate the recurrence of intraosseous ameloblastoma by conservative and aggressive treatment approaches were included.ResultsA total of 20 studies with 942 ameloblastoma cases were included. Fourteen studies included patients with ameloblastoma who received conservative treatment, and 16 studies reported the overall recurrence rate for patients undergoing aggressive treatment. The pooled results indicated that the recurrence rate for aggressive treatment [0.12, 95% confidence interval (CI) = 0.09–0.16] was significantly lower than that for conservative treatment, with a recurrence rate of 0.30 (95% CI = 0.23–0.39). Similar results were obtained when stratifying the participants by the histological classification. When trying stratification analysis following the original included studies, multicystic ameloblastoma presented a much higher recurrence rate than solid and unicystic ameloblastomas.ConclusionThese findings supported the hypothesis that aggressive treatment might lead to a lower recurrence rate than conservative treatment. More studies and meta-analyses following the new histological classification of ameloblastomas are needed to validate and support the findings.

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Section: Discussionmentioning

confidence: 99%

Recurrence Rates of Intraosseous Ameloblastoma Cases With Conservative or Aggressive Treatment: A Systematic Review and Meta-Analysis

et al. 2021

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“…Ameloblastoma is regarded as the most clinically significant tumor of odontogenic origin since it is locally aggressive and has a very high recurrence rate after inadequate or conservative treatment 2,3. It constitute approximately 1% of all oral tumors and about 12% of odontogenic tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The sampling was done by non-probability and purposive technique (Select the sample on the basis of our knowledge of the population and nature of our research aims). The sample size was calculated on the frequency of ameloblastoma, as it includes only 1% of the oral tumors, however, 50 samples were recommended by to the IRB to draw some inferential 2,3,10…”

Section: Methodsmentioning

confidence: 99%

“…Broca first described an odontogenic neoplasm in 1868 and various classifications have been proposed 1. Ameloblastoma is the most common OT, approximately 1% of all oral tumours and affecting young adults in the fourth and fifth decades 2,3. As there was little clinical evidence for the classification into plexiform type and follicular type, the WHO subsequently reclassified ameloblastoma into solid/multicystic type, unicystic type, extraosseous/peripheral type, and desmoplastic type 4…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry

et al. 2019

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Objective: To study the clinocopathological factors and presence of Human Pappiloma Virus in ameloblastoma by immnohistochemistry. Methods: It was a cross sectional study on 50 surgical specimens of ameloblastoma, completed in six months. These were selected and processed for initial screening by H&E and then by immunohistochemistry (IHC) for detection of Human Papilloma Virus (HPV). The questionnaire was designed to study the clinicopathological factors associated in these patients. Sections of 4µm were cut, placed on special positive charged glass slides in the Department of Pathology, King Edward Medical University. It was then examined by the histopathologists for grading and scoring of these lesions. Chi Square test was used to assess the differences found in types of ameloblastomas. The p-value was smaller than 0.05 (p < 0.05). Results: The mean age of the patients (12-80 years old) was 38.6±15.1 years, with male-female ratio 2.84: 1. HPV was positive in 9 (18%), whereas negative in of 41 (82%) patients. Among the positive, reactive HPV with score-1 was 8 and score-2 was 1. According to histological variant, follicular was present in 78%, Plexiform pattern in 8%, Conventional and Desmoplastic variants in one patient each; and Cystic and Acanthomatous were seen in two and three patients respectively. The mandible was involved in 39 patients, maxilla and right maxilla involved in 4 patients each, right retromolar, cheek and angle of mandible was seen in one patient each. About 16% patients had anterior, 66% had posterior and 18% had both anterior and posterior regions involved. Among the HPV positive reactive statistically, no significant difference was found with smoking, Paan and exposure to pesticides, factory or mine (p-value > 0.05). Among HPV positive reactive patients, eight had ameloblastoma whereas, 1 had ameloblastomic fibroma. There was no statistical significance of type, location and region of tumor in HPV positivity. Conclusion: Mandible and posterior region was more commonly involved. Follicular pattern was most common. There was no effect of exposure to pesticides, factory or mine, smoke and human papilloma virus in the etiology of ameloblastoma because only 18% of patients showed the association of HPV16 doi: https://doi.org/10.12669/pjms.35.6.909 How to cite this:Ali M, Bukhari MH, Hassan F, Illyas M. Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry. Pak J Med Sci. 2019;35(6):1691-1696. doi: https://doi.org/10.12669/pjms.35.6.909 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…From these findings, differential diagnosis is required to distinguish ameloblastic fibroma, odontogenic fibroma, and squamous odontogenic tumor. [5]…”

Section: Discussionmentioning

confidence: 99%

Ameloblastoma: Reconstruction using titanium plates adapted using stereolithographic models

Chutchurru

Brusca

Palavecino

2018

Ann Maxillofac Surg

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Ameloblastoma is a benign but locally invasive odontogenic tumor that causes significant morbidity. The aim is to study an ameloblastoma treatment with reconstruction using titanium plates adapted using stereolithographic models. A 48-year-old female patient referred due to asymptomatic osteolytic lesion between teeth 47 and 48 discovered during routine radiographic study. The pathoanatomical study described a desmoplastic ameloblastoma. Due to the possibility of it being a malignant lesion, a computerized axial tomography scan was performed, which showed that the tumor was not malignant. A stereolithographic model was prepared to make the cutting guides and facilitate fitting of reconstruction plates. Three-dimensional printing technology enables fast, accurate mandibular reconstruction, helping to shorten operation time.

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Clinicopathological characteristics of desmoplastic ameloblastoma: A systematic review

Cited by 7 publications

References 69 publications

Recurrence Rates of Intraosseous Ameloblastoma Cases With Conservative or Aggressive Treatment: A Systematic Review and Meta-Analysis

Recurrence Rates of Intraosseous Ameloblastoma Cases With Conservative or Aggressive Treatment: A Systematic Review and Meta-Analysis

Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry

Ameloblastoma: Reconstruction using titanium plates adapted using stereolithographic models

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