Clinicopathological characteristics of intracranial meningiomas

Abstract

Background: Meningioma comprises 25-30% of total central nervous system tumors detected. Ninety percent of meningiomas are benign, 6% are atypical, and 2% are malignant. Complete resection is often curative.
 Objectives: The objective of this study is to give ideas about the descriptive epidemiology, clinical presentation and histopathology of current scenario at National Neurosurgical Referral Center, Nepal.
 Methods: This is a prospective study from the period of January 2015 to September 2019 in the department of neurosurgery, National Academy of Medical Science, Bir Hospital. Inclusion criteria consists of all the histopathological proven cases of meningioma during the study period.
 Result: A total of 150 meningioma cases were operated during the study period. The average age of presentation was 42 years. Male to female ratio was 1:2. Most common affected age group was 30-50 years. The most common clinical symptoms for intracranial meningioma were headache followed by vomiting and paresis. Among intracranial meningioma, the most common location was convexity meningioma followed by sphenoid wing meningiomas and parasagittal meningiomas. Most common histopathological variety encountered was transitional meningioma, World health organization grade I.
 Conclusion: Meningiomas are slow growing, extra-axial tumor, usually benign which are most commonly located along convexities, sphenoid ridge and parasagittal area. Most are cured if completely removed, which is not always possible.

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

“…The results of the demographic analysis of orbital meningioma (Table 1) showed that the disease was most prevalent among respondents aged 30-44 years. Orbital meningiomas usually occur in the 3-4 decades of life, as reported in recent findings that it was common in people aged 30-50 years [19], [20]. In this study, female respondents occupied the highest proportion or 90.9%, which confirmed the previous studies that 75.6% of orbital meningiomas happened to adult women [4], [21].…”

“…The incidence ratio of orbital meningioma in female to male is 3:1. The higher prevalence of meningioma is observed among postmenopausal women received exogenous hormone replacement therapy (e.g., contraception) compared to those without the therapy [20], [22].…”

“…Group II patients are at moderate risk with Grade II meningioma after crude resection or recurrent Grade I meningioma. Group III patients are at high risk and include those diagnosed with Grade III meningioma, Grade II recurrent meningioma, and newly diagnosed Grade II meningioma who undergo subtotal resection [20].…”